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Themed collection Editor’s Collection: Mechanochemistry

60 items
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Reactive milling with metals for environmentally benign sustainable production

Two decades of reactive milling for environmentally benign sustainable production with metals.

Graphical abstract: Reactive milling with metals for environmentally benign sustainable production
Highlight

Mechanochemistry: the varied applications of mechanical bond-breaking

Mechanical impact breaks infinitely covalent crystals providing surface plasma with exciting applications. Polymer technology profits from bond breaking with radical formation. Crashed (semi)metals start improved syntheses as do weak-bond molecules including explosives. Strong bonds in small molecules break by shear under Bridgman's anvil and at lubrication. Single bond breaking and nano-dissection are emerging.

Graphical abstract: Mechanochemistry: the varied applications of mechanical bond-breaking
From the themed collection: Mechanochemistry and cocrystals
Communication

Mechanochemical synthesis of brexpiprazole cocrystals to improve its pharmaceutical attributes

In the present study, cocrystallization of a new piprazole analogue drug, brexpiprazole (BREX), with coformers such as succinic acid and catechol was carried out using ball milling to address the poor solubility and dissolution rate of the molecule.

Graphical abstract: Mechanochemical synthesis of brexpiprazole cocrystals to improve its pharmaceutical attributes
From the themed collection: Editor’s Collection: Mechanochemistry
Open Access Communication

Cocrystal formation by ionic liquid-assisted grinding: case study with cocrystals of caffeine

Liquid assisted grinding using imidazolium-based ionic liquids (IL-AG) was found to be effective in isolation of cocrystals and cocrystal polymorphs.

Graphical abstract: Cocrystal formation by ionic liquid-assisted grinding: case study with cocrystals of caffeine
From the themed collection: Editor’s Collection: Mechanochemistry
Communication

Reversible mechanochromic and thermochromic luminescence switching via hydrogen-bond-directed assemblies in a zinc coordination complex

A zinc coordination complex with terpyridyl derivative as ligand exhibits mechanochromic and thermochromic luminescence behaviors with reversible color changes visible to the naked eye from pink to blue-purple upon mechanical grinding and from pink to blue upon heating.

Graphical abstract: Reversible mechanochromic and thermochromic luminescence switching via hydrogen-bond-directed assemblies in a zinc coordination complex
From the themed collection: Editor’s Collection: Mechanochemistry
Open Access Communication

Inadvertent liquid assisted grinding: a key to “dry” organic mechano-co-crystallisation?

The paper provides a prime example where liquid is required for a reaction, but simultaneously inhibits it. The results offer insights into possible regional, seasonal, polymer additive and temperature effects on mechanochemical synthesis.

Graphical abstract: Inadvertent liquid assisted grinding: a key to “dry” organic mechano-co-crystallisation?
From the themed collection: Editor’s Collection: Mechanochemistry
Communication

Mechanical path to a photogenerated structure: ball milling-induced phase transition of a gold(I) complex

Ball milling of blue-emitting crystal 1B of gold(I) isocyanide complex 1 induces a phase transition to yellow-emitting powder 1YG, which has the same solid structure as the previously reported 1Y obtained upon photoirradiation of 1B.

Graphical abstract: Mechanical path to a photogenerated structure: ball milling-induced phase transition of a gold(i) complex
From the themed collection: Editor’s Collection: Mechanochemistry
Open Access Communication

Halogen bonding of N-bromosuccinimide by grinding

Two halogen bonded cocrystals of N-bromosuccinimide and 4,4′-bipyridine, with stoichiometric ratios 1 : 1 and 2 : 1, have been synthesized and characterized. We present the first mechanochemical cocrystallization of N-bromosuccinimide.

Graphical abstract: Halogen bonding of N-bromosuccinimide by grinding
From the themed collection: Editor’s Collection: Mechanochemistry
Open Access Communication

Exploiting polymorphism in second sphere coordination: thermal transformation, NLO properties and selective mechanochemical synthesis

Polymorphism has been explored in a second sphere adduct using a racemic ligand that also shows racemic polymorphic behavior. The polar nature of the second sphere adduct allowed us to study NLO phenomena.

Graphical abstract: Exploiting polymorphism in second sphere coordination: thermal transformation, NLO properties and selective mechanochemical synthesis
From the themed collection: Editor’s Collection: Mechanochemistry
Open Access Communication

Fast and efficient synthesis of a host guest system: a mechanochemical approach

In situ investigation and elucidation of the formation of a POM@MOF host guest system obtained by mechanosynthesis.

Graphical abstract: Fast and efficient synthesis of a host guest system: a mechanochemical approach
From the themed collection: Editor’s Collection: Mechanochemistry
Communication

Structure-dependent mechanochromism of two Ag(I) imidazolate chains

A Ag(I)-imidazolate coordination polymer showed unique luminescence mechanochromism due to the Ag⋯Ag and C–H⋯π interactions.

Graphical abstract: Structure-dependent mechanochromism of two Ag(i) imidazolate chains
From the themed collection: Editor’s Collection: Mechanochemistry
Communication

Nanoscale 2CL-20·HMX high explosive cocrystal synthesized by bead milling

Nanoscale cocrystal of CL-20 and HMX with a rounded morphology was prepared by bead milling an aqueous suspension of the coformers.

Graphical abstract: Nanoscale 2CL-20·HMX high explosive cocrystal synthesized by bead milling
From the themed collection: Editor’s Collection: Mechanochemistry
Communication

Phase transformation of mesoporous calcium carbonate by mechanical stirring

Mechanically stirring the precursor colloidal dispersion can control the polymorphs of mesoporous calcium carbonate.

Graphical abstract: Phase transformation of mesoporous calcium carbonate by mechanical stirring
From the themed collection: Editor’s Collection: Mechanochemistry
Communication

Attrition-induced spontaneous chiral amplification of the γ polymorphic modification of glycine

Glycine is the simplest achiral amino acid that undergoes spontaneous mirror symmetry and controlled deracemization in its γ-polymorphic modification.

Graphical abstract: Attrition-induced spontaneous chiral amplification of the γ polymorphic modification of glycine
From the themed collection: Editor’s Collection: Mechanochemistry
Communication

Synthesis of an extended halogen-bonded metal–organic structure in a one-pot mechanochemical reaction that combines covalent bonding, coordination chemistry and supramolecular synthesis

We describe a four-component one-pot mechanochemical reaction which combines the formation of covalent bonds, coordination bonds and halogen bonds to obtain an extended structure based on halogen-bonded metal–organic units.

Graphical abstract: Synthesis of an extended halogen-bonded metal–organic structure in a one-pot mechanochemical reaction that combines covalent bonding, coordination chemistry and supramolecular synthesis
From the themed collection: Editor’s Collection: Mechanochemistry
Communication

A carbamazepine-indomethacin (1 : 1) cocrystal produced by milling

An X-ray amorphous mixture of carbamazepine and indomethacin transforms upon annealing to produce a novel 1 : 1 cocrystal.

Graphical abstract: A carbamazepine-indomethacin (1 : 1) cocrystal produced by milling
From the themed collection: Editor’s Collection: Mechanochemistry
Communication

A rational approach to screen for hydrated forms of the pharmaceutical derivative magnesium naproxen using liquid-assisted grinding

Systematic variation of water activity in the grinding liquid enables a rational strategy to mechanochemically screen for hydrated forms of magnesium-based pharmaceutical derivatives formed in situ from MgO and naproxen.

Graphical abstract: A rational approach to screen for hydrated forms of the pharmaceutical derivative magnesium naproxen using liquid-assisted grinding
Communication

Supramolecular metathesis: co-former exchange in co-crystals of pyrazine with (R,R)-, (S,S)-, (R,S)- and (S,S/R,R)-tartaric acid

Co-crystals of dextro-(R,R), levo-(S,S), meso-(R,S) and racemic (R,RS,S)-tartaric acid with pyrazine were obtained by manual kneading and slurry experiments; upon their reaction with the various tartaric acid forms co-former exchange takes place, according to the sequence of stability [(R,S)-ta]2·py > (S,S/R,R)-ta·py > (R,R)-ta·py or (S,S)-ta·py.

Graphical abstract: Supramolecular metathesis: co-former exchange in co-crystals of pyrazine with (R,R)-, (S,S)-, (R,S)- and (S,S/R,R)-tartaric acid
Communication

Following the products of mechanochemical synthesis step by step

We describe a model study of “solid + solid” reaction with control over number, energy, duration, and frequency of individual mechanical pulses.

Graphical abstract: Following the products of mechanochemical synthesis step by step
From the themed collection: Editor’s Collection: Mechanochemistry
Communication

Study of the mechanochemical formation and resulting properties of an archetypal MOF: Cu3(BTC)2 (BTC = 1,3,5-benzenetricarboxylate)

A study of the MOF formation by grinding together solid reactants in a ball mill reveals interesting aspects of morphology and reactivity; the product could also be activated to exhibit appreciable surface areas (>1300 m2g−1) although washing with solvent was required.

Graphical abstract: Study of the mechanochemical formation and resulting properties of an archetypal MOF: Cu3(BTC)2 (BTC = 1,3,5-benzenetricarboxylate)
From the themed collection: Editor’s Collection: Mechanochemistry
Communication

New solid forms of artemisinin obtained through cocrystallisation

Cocrystals of artemisinin, an artificial antimalarial drug lacking sites for forming conventional supramolecular synthons, have been obtained by mechanochemical screening and the results analysed using molecular descriptors derived from the CSD.

Graphical abstract: New solid forms of artemisinin obtained through cocrystallisation
From the themed collection: Editor’s Collection: Mechanochemistry
Communication

Solid state crystal-to-crystal transformation from a monomeric structure to 1-D coordination polymers on anion exchange,

Yellow crystals of monomeric structure [Zn(bpdh)2(H2O)4](NO3)2·2bpdh (1) convert on heating at ca. 160 °C under grinding and mixing with KSCN or NaN3 to white and orange 1D coordination polymers, [Zn(µ-bpdh)2(NCS)2]n (2) and [Zn(µ-bpdh)2(N3)2]n (3), respectively.

Graphical abstract: Solid state crystal-to-crystal transformation from a monomeric structure to 1-D coordination polymers on anion exchange,
From the themed collection: Editor’s Collection: Mechanochemistry
Communication

Drug-containing coordination and hydrogen bonding networks obtained mechanochemically

Coordination and hydrogen bonding networks of the antibiotic 4-aminosalicylic acid and of the nootropic drug piracetam with silver and nickel cations have been prepared mechanochemically; in the case of silver, solid-state and solution reactions afforded different crystalline materials.

Graphical abstract: Drug-containing coordination and hydrogen bonding networks obtained mechanochemically
From the themed collection: Editor’s Collection: Mechanochemistry
Communication

Mechanochemical conversion of a metal oxide into coordination polymers and porous frameworks using liquid-assisted grinding (LAG)

Mechanochemical method of liquid-assisted grinding enables rapid and clean conversion of an inexpensive metal oxide into diverse coordination polymers and porous frameworks for preparative and screening purposes.

Graphical abstract: Mechanochemical conversion of a metal oxide into coordination polymers and porous frameworks using liquid-assisted grinding (LAG)
From the themed collection: Editor’s Collection: Mechanochemistry
Communication

The utility of a ternary phase diagram in the discovery of new co-crystal forms

The construction of the ternary phase diagram urea–glutaric acid–water has led to the discovery of a new co-crystal form.

Graphical abstract: The utility of a ternary phase diagram in the discovery of new co-crystal forms
From the themed collection: Mechanochemistry and cocrystals
Communication

Nonlinear effects in proline-catalysed aldol reactions under solvent-free conditions based on the ternary phase behaviour of scalemic proline

Under solvent-free conditions in a ball mill a significant nonlinear relationship between the enantiomeric excess of the catalyst (proline) and that of the product was observed, when solely solid substrates were used.

Graphical abstract: Nonlinear effects in proline-catalysed aldol reactions under solvent-free conditions based on the ternary phase behaviour of scalemic proline
From the themed collection: Mechanochemistry and cocrystals
Communication

Nicotinamide fumaric acid supramolecular cocrystals: diversity of stoichiometry

Synthesis of nicotinamide and fumaric acid supramolecular cocrystals with 1 : 1 and 2 : 1 amide to acid stoichiometries results in the formation of an amide–acid heterosynthon (1 : 1 stoichiometry) and an amide–amide homosynthon (2 : 1 stoichiometry) and different conformations of the fumaric acid moieties.

Graphical abstract: Nicotinamide fumaric acid supramolecular cocrystals: diversity of stoichiometry
From the themed collection: Mechanochemistry and cocrystals
Communication

Simple and quantitative mechanochemical preparation of the first zinc and copper complexes of the neuroleptic drug gabapentin

The solid-state preparation and structural characterization of the first two coordination complexes of the neuroleptic drug gabapentin.

Graphical abstract: Simple and quantitative mechanochemical preparation of the first zinc and copper complexes of the neuroleptic drug gabapentin
From the themed collection: Editor’s Collection: Mechanochemistry
Communication

Solvent-free synthesis of a microporous metal–organic framework

Solvent-free grinding is demonstrated as an effective way to produce a porous 3-dimensional metal–organic framework.

Graphical abstract: Solvent-free synthesis of a microporous metal–organic framework
From the themed collection: Editor’s Collection: Mechanochemistry
Communication

Unprecedented mechanochemical preparation of 18Crown[6] and 15Crown[5] adducts of ammonium hydrogen sulfate by grinding or kneading

Novel crown ether complexes, 18Crown[6]·[NH4][HSO4]·2H2O and (15Crown[5])3·[NH4]2[H3O][HSO4]3·H2O have been prepared, respectively, by grinding and kneading of solid 18Crown[6] and of liquid 15Crown[5] with solid [NH4][HSO4].

Graphical abstract: Unprecedented mechanochemical preparation of 18Crown[6] and 15Crown[5] adducts of ammonium hydrogen sulfate by grinding or kneading
From the themed collection: Editor’s Collection: Mechanochemistry
Communication

Mechanochemical and solution preparation of the coordination polymers Ag[N(CH2CH2)3N]2[CH3COO]·5H2O and Zn[N(CH2CH2)3N]Cl2

Two solid-state coordination reactions for the polymers g[N(CH2CH2)3N]2[CH3COO]·5H2O and Zn[N(CH2CH2)3N] and their solution counterparts, as well as two discussions of X-ray results are presented.

Graphical abstract: Mechanochemical and solution preparation of the coordination polymers Ag[N(CH2CH2)3N]2[CH3COO]·5H2O and Zn[N(CH2CH2)3N]Cl2
From the themed collection: Editor’s Collection: Mechanochemistry
Paper

The mechanochemical conversion of potassium coordination polymer nanostructures to interpenetrated sodium coordination polymers with halogen bond, metal–carbon and metal–metal interactions

Two new Na and K coordination polymers with halogen bond, metallophilic and hydrogen bonding interactions were synthesized. These two compounds were synthesized sonochemically and solid-state conversions of them to each other were investigated.

Graphical abstract: The mechanochemical conversion of potassium coordination polymer nanostructures to interpenetrated sodium coordination polymers with halogen bond, metal–carbon and metal–metal interactions
From the themed collection: Supramolecular & Polymorphism
Paper

Stoichiometry mechanosynthesis and interconversion of metal salts containing [CuCl3(H2O)] and [Cu2Cl8]4−

The mechanochemical interconversion of two salts was achieved by the addition of an appropriate amount of one of the corresponding components (HL or CuCl2·2H2O), and the progress of dynamic interconversion was revealed by PXRD, fluorescence and Raman spectroscopy.

Graphical abstract: Stoichiometry mechanosynthesis and interconversion of metal salts containing [CuCl3(H2O)]− and [Cu2Cl8]4−
From the themed collection: Editor’s Collection: Mechanochemistry
Paper

Affinity prediction computations and mechanosynthesis of carbamazepine based cocrystals

A combination of the excess enthalpy with the fusion entropy of the pure coformer is suggested to be of interest for coformers screening in order to form a multicomponent system with a given API (cocrystal/co-amorphous).

Graphical abstract: Affinity prediction computations and mechanosynthesis of carbamazepine based cocrystals
From the themed collection: Editor’s Collection: Mechanochemistry
Open Access Paper

Ball size or ball mass – what matters in organic mechanochemical synthesis?

The effects of milling ball mass, size and material are isolated for a model mechanochemical co-crystallisation.

Graphical abstract: Ball size or ball mass – what matters in organic mechanochemical synthesis?
From the themed collection: Editor’s Collection: Mechanochemistry
Paper

On the kinetics of solvate formation through mechanochemistry

We demonstrate that solvates obtained through mechanochemistry are the thermodynamic products, and that the kinetics of solvate formation are related to the easiness of breaking the reactant crystals.

Graphical abstract: On the kinetics of solvate formation through mechanochemistry
From the themed collection: Editor’s Collection: Mechanochemistry
Paper

Dynamic behaviour in nonporous hybrid metal–organic materials via mechanochemical and gas–solid reactions

Nonporous hybrid metal organic materials have been studied in the solid-state by mechanochemical reactions, chemisorption and release of HCl by heating. The dynamic behavior of the hybrid materials allows the breaking and formation of chemical bonds.

Graphical abstract: Dynamic behaviour in nonporous hybrid metal–organic materials via mechanochemical and gas–solid reactions
From the themed collection: Editor’s Collection: Mechanochemistry
Paper

Comparative studies on conventional and solvent-free synthesis toward hydrazones: application of PXRD and chemometric data analysis in mechanochemical reaction monitoring

We describe the implementation of chemometric analysis for mechanochemical synthesis monitoring.

Graphical abstract: Comparative studies on conventional and solvent-free synthesis toward hydrazones: application of PXRD and chemometric data analysis in mechanochemical reaction monitoring
From the themed collection: Editor’s Collection: Mechanochemistry
Open Access Paper

Polymorphism of chlorpropamide on liquid-assisted mechanical treatment: choice of liquid and type of mechanical treatment matter

Different types of mechanical treatment (tableting, grinding, milling, etc.) are important technological operations in the pharmaceutical industry.

Graphical abstract: Polymorphism of chlorpropamide on liquid-assisted mechanical treatment: choice of liquid and type of mechanical treatment matter
From the themed collection: Editor’s Collection: Mechanochemistry
Paper

The effect of the ball to reactant ratio on mechanochemical reaction times studied by in situ PXRD

The effect of the ball to reactant ratio on reaction times for a cocrystal formation was studied by in situ PXRD.

Graphical abstract: The effect of the ball to reactant ratio on mechanochemical reaction times studied by in situ PXRD
From the themed collection: Editor’s Collection: Mechanochemistry
Paper

Mechanochemically synthesized crystalline luminescent 2D coordination polymers of La3+ and Ce3+, doped with Sm3+, Eu3+, Tb3+, and Dy3+: synthesis, crystal structures and luminescence

A convenient mechanochemical synthesis method has been used to produce luminescent 2D rare-earth coordination polymers.

Graphical abstract: Mechanochemically synthesized crystalline luminescent 2D coordination polymers of La3+ and Ce3+, doped with Sm3+, Eu3+, Tb3+, and Dy3+: synthesis, crystal structures and luminescence
From the themed collection: Editor’s Collection: Mechanochemistry
Paper

Isoniazid cocrystallisation with dicarboxylic acids: vapochemical, mechanochemical and thermal methods

A systematic study on mechanochemical, thermal and vapochemical cocrystallisation demonstrates the effect of compound properties on the outcome of the reaction.

Graphical abstract: Isoniazid cocrystallisation with dicarboxylic acids: vapochemical, mechanochemical and thermal methods
From the themed collection: Editor’s Collection: Mechanochemistry
Paper

Polymorphism control in the mechanochemical and solution-based synthesis of a thermochromic Schiff base

Three crystal forms of a thermochromic Schiff base derived from o-vanillin and 3-aminoacetophenone were obtained by conventional solution-based methods. Two polymorphs out of three were synthesized by mechanochemical syntheses, under solvent-free conditions.

Graphical abstract: Polymorphism control in the mechanochemical and solution-based synthesis of a thermochromic Schiff base
From the themed collection: Editor’s Collection: Mechanochemistry
Paper

Structural and optical characterization of ball-milled copper-doped bismuth vanadium oxide (BiVO4)

Mechano-chemical synthesis of Cu-doped BiVO4 monoclinic nanopowders and investigation of structural, optical and electronic properties.

Graphical abstract: Structural and optical characterization of ball-milled copper-doped bismuth vanadium oxide (BiVO4)
From the themed collection: Editor’s Collection: Mechanochemistry
Paper

Studies on polymorph conversion in a new cyclodextrin inclusion compound

4-Phenylpyridine-N-oxide and βCD form a stoichiometric inclusion complex with two polymorphs occurring at different crystallisation times. The irreversible conversion of one polymorph into the other was monitored in real time for the first time.

Graphical abstract: Studies on polymorph conversion in a new cyclodextrin inclusion compound
From the themed collection: Editor’s Collection: Mechanochemistry
Paper

Rapid mechanochemical synthesis of two new Cd(II)-based metal–organic frameworks with high removal efficiency of Congo red

Two new three-dimensional porous Cd(II)-based metal–organic frameworks, TMU-8 and TMU-9, with high performance in adsorption of Congo red.

Graphical abstract: Rapid mechanochemical synthesis of two new Cd(ii)-based metal–organic frameworks with high removal efficiency of Congo red
From the themed collection: Editor’s Collection: Mechanochemistry
Paper

The effect of mechano-stimuli on the amorphous-to-crystalline transition of mechanochromic luminescent materials

Mechano-stimuli, which causes mechanochromic luminescence when being applied on crystalline materials, facilitates the annealing crystallization of amorphous materials.

Graphical abstract: The effect of mechano-stimuli on the amorphous-to-crystalline transition of mechanochromic luminescent materials
From the themed collection: Editor’s Collection: Mechanochemistry
Paper

Improvement of the water solubility of tolfenamic acid by new multiple-component crystals produced by mechanochemical methods

Tolfenamic acid (HTA) is a drug characterized by very poor solubility in water. By mechanochemical methods, new solid-state forms of HTA were obtained, showing better thermal stability than pure HTA and an improved dissolution rate.

Graphical abstract: Improvement of the water solubility of tolfenamic acid by new multiple-component crystals produced by mechanochemical methods
From the themed collection: Editor’s Collection: Mechanochemistry
Paper

The role of a liquid in “dry” co-grinding: a case study of the effect of water on mechanochemical synthesis in a “L-serine–oxalic acid” system

[L-serH]2[ox]·2H2O form II proved to be an intermediate product in the reaction for obtaining the form I.

Graphical abstract: The role of a liquid in “dry” co-grinding: a case study of the effect of water on mechanochemical synthesis in a “l-serine–oxalic acid” system
From the themed collection: Editor’s Collection: Mechanochemistry
Paper

Mechanochemical dehydrochlorination and chelation reaction in the solid state: from a molecular salt to a coordination complex

A solid-state reaction from a metal organic salt into a coordination complex is achieved via a dehydrochlorination reaction by grinding.

Graphical abstract: Mechanochemical dehydrochlorination and chelation reaction in the solid state: from a molecular salt to a coordination complex
From the themed collection: Editor’s Collection: Mechanochemistry
Paper

‘Hedvall effect’ in cryogrinding of molecular crystals. A case study of a polymorphic transition in chlorpropamide

A phase transition, induced by low temperature, facilitates another one, induced by mechanical treatment.

Graphical abstract: ‘Hedvall effect’ in cryogrinding of molecular crystals. A case study of a polymorphic transition in chlorpropamide
Paper

A stepwise mechanism and the role of water in the liquid-assisted grinding synthesis of metal–organic materials

Mechanosynthesis of metal–organic materials from ZnO or CuO proceeds via a stepwise mechanism and can be regulated by the mole fraction and the activity of water in the grinding liquid.

Graphical abstract: A stepwise mechanism and the role of water in the liquid-assisted grinding synthesis of metal–organic materials
From the themed collection: New Talent
Paper

Mechanochemical preparation of adducts (co-crystals and molecular salts) of 1,4-diazabicyclo-[2.2.2]-octane with aromatic polycarboxylic acids

Solid-state adducts of DABCO with aromatic polycarboxylic acids were prepared in the solid state by grinding and kneading techniques; the extent of proton transfer between acids and base reflects the trend of solution acidity of the three polycarboxylic acids.

Graphical abstract: Mechanochemical preparation of adducts (co-crystals and molecular salts) of 1,4-diazabicyclo-[2.2.2]-octane with aromatic polycarboxylic acids
From the themed collection: Editor’s Collection: Mechanochemistry
Paper

Dimorphs of a 1 : 1 cocrystal of ethenzamide and saccharin: solid-state grinding methods result in metastable polymorph

The ability of solid-state grinding methods, such as neat grinding and solvent-drop grinding, to produce the metastable polymorph of a cocrystal is exemplified by dimorphs of a cocrystal between an analgesic drug, ethenzamide, and saccharin.

Graphical abstract: Dimorphs of a 1 : 1 cocrystal of ethenzamide and saccharin: solid-state grinding methods result in metastable polymorph
From the themed collection: Editor’s Collection: Mechanochemistry
Paper

Cyanooximes as effective and selective co-crystallizing agents

The cyanooxime preferentially binds to the moiety with the most negative electrostatic potential in a heteroditopic (benzimidazole-pyridine) hydrogen-bond acceptor.

Graphical abstract: Cyanooximes as effective and selective co-crystallizing agents
From the themed collection: Mechanochemistry and cocrystals
Paper

Annealing assisted mechanochemical syntheses of transition-metal coordination compounds and co-crystal formation

Annealing assisted mechanochemical grinding of transition metal complexes activates molecules to form coordination polymers, or encourages diffusion/rearrangement of component molecules to form new crystals by way of recognition or transfer of chirality.

Graphical abstract: Annealing assisted mechanochemical syntheses of transition-metal coordination compounds and co-crystal formation
From the themed collection: Mechanochemistry and cocrystals
Paper

SFM study of the surface of halogen-bonded hybrid co-crystals containing long-chain perfluorocarbons

We report the first in-depth SFM characterization of a prototype halogen-bonded crystalline system to obtain structural and surface compositional information, and investigate nanoscale properties. We expect this study to impact the rational design of perfluorocarbon–hydrocarbon systems, leading to co-crystals with engineered surfaces and predictable properties.

Graphical abstract: SFM study of the surface of halogen-bonded hybrid co-crystals containing long-chain perfluorocarbons
From the themed collection: Mechanochemistry and cocrystals
Paper

Structural similarities of 2-chlorophenol and 2-methylphenol

Investigation of 2-methylphenol and 2-chlorophenol reveals similarities in structure at both low temperature and high pressure. Co-crystallisation of the two components results in the formation of a 0.45 : 0.55 2-methylphenol : 2-chlorophenol co-crystal at low temperature but at high pressure the mixture is separated resulting in the formation of a new polymorph of 2-chlorophenol.

Graphical abstract: Structural similarities of 2-chlorophenol and 2-methylphenol
From the themed collection: Editor’s Collection: Mechanochemistry
Paper

The role of solvent in mechanochemical and sonochemical cocrystal formation: a solubility-based approach for predicting cocrystallisation outcome

Liquid-assisted grinding (LAG) and sonochemical (SonicSlurry) techniques in cocrystallisation were compared by introducing a parameter (η) that allows interpreting and predicting cocrystal formation in a range of solvents and concentrations by considering reactant saturation levels.

Graphical abstract: The role of solvent in mechanochemical and sonochemical cocrystal formation: a solubility-based approach for predicting cocrystallisation outcome
From the themed collection: Mechanochemistry and cocrystals
Paper

An array-based study of reactivity under solvent-free mechanochemical conditions—insights and trends

Reactions between metal salts and bridging ligands in a ball mill are found to be remarkably general. Some insights and trends are revealed by studying an array of 60 potential reactions between various ligands and metal salts.

Graphical abstract: An array-based study of reactivity under solvent-free mechanochemical conditions—insights and trends
60 items

About this collection

This Editor’s collection, guest edited by Editorial Board Member Elena Boldyreva highlights a number of articles in the field of Mechanochemistry.

Mechanochemistry is a branch of chemistry which has been known for a long time and yet has undergone rapid development in the last two decades and indeed IUPAC has recently included mechanochemistry in top-5 innovations that will change the world. (https://www.chemistryworld.com/news/iupac-names-10-chemistry-innovations-that-will-change-the-world/3010335.article)

CrystEngComm has published a number of cutting-edge papers on mechanochemistry in the twenty years that the journal has existed. The first paper on mechanochemistry was published in 2004, and since then papers on various aspects of mechanochemistry have appeared regularly, including a themed issue focusing on Mechanochemistry and cocrystals published in 2009. These papers have reported new synthesis, new techniques, as well as the results of original and profound mechanistic studies.

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