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Themed collection Cucurbiturils and related cavitands

25 items
Feature Article

Glycoluril derived cucurbituril analogues and the emergence of the most recent example: tiarauril

Cucurbituril analogues can bear some of the chemical and physical characteristics of their parental origin and are derived wholly or in part from glycolurils (including homologues).

Graphical abstract: Glycoluril derived cucurbituril analogues and the emergence of the most recent example: tiarauril
From the themed collection: Cucurbiturils and related cavitands
Feature Article

Modelling haemoproteins: porphyrins and cyclodextrins as sources of inspiration

Associations of hydrophobic cavities with porphyrin derivatives used to mimic haemoprotein structures are featured in this article and may inspire innovative research in the field of cucurbiturils.

Graphical abstract: Modelling haemoproteins: porphyrins and cyclodextrins as sources of inspiration
From the themed collection: Cucurbiturils and related cavitands
Feature Article

Cucurbit[n]uril-based amphiphiles that self-assemble into functional nanomaterials for therapeutics

In this feature article, the two types (molecular amphiphile and supramolecular amphiphile) of CB-based amphiphiles, their self-assemblies and their applications for useful nanotherapeutics and theranostics are presented with future perspectives.

Graphical abstract: Cucurbit[n]uril-based amphiphiles that self-assemble into functional nanomaterials for therapeutics
From the themed collection: Cucurbiturils and related cavitands
Communication

Supra-blot: an accurate and reliable assay for detecting target proteins with a synthetic host molecule–enzyme hybrid

A new way to detect target proteins is developed using a high-affinity host–guest interaction for a wide variety of biological samples including bacteria and mammalian cells.

Graphical abstract: Supra-blot: an accurate and reliable assay for detecting target proteins with a synthetic host molecule–enzyme hybrid
From the themed collection: Cucurbiturils and related cavitands
Communication

Engineered assembly of a protein–cucurbituril biohybrid

Additional Q7 binding sites drive protein aggregation in solution and statistical disorder in the crystalline biohybrid suggest new possibilities for protein-based materials.

Graphical abstract: Engineered assembly of a protein–cucurbituril biohybrid
From the themed collection: Cucurbiturils and related cavitands
Open Access Communication

Supramolecular chirogenesis in zinc porphyrins by enantiopure hemicucurbit[n]urils (n = 6, 8)

Chiral cyclohexanohemicucurbit[n]urils with multiple interaction sites induce chirality on planar zinc porphyrins and bind up to three porphyrin molecules.

Graphical abstract: Supramolecular chirogenesis in zinc porphyrins by enantiopure hemicucurbit[n]urils (n = 6, 8)
From the themed collection: Cucurbiturils and related cavitands
Communication

Dynamic host–guest interaction enables autonomous single molecule blinking and super-resolution imaging

Specific yet dynamic interaction in cucurbit[7]uril (CB[7]) system was used to obtain programmable fluorescence blinking with necessary brightness and frequency to enable two-dimensional (2D) and 3D super-resolution imaging of proteins in cells.

Graphical abstract: Dynamic host–guest interaction enables autonomous single molecule blinking and super-resolution imaging
From the themed collection: Cucurbiturils and related cavitands
Communication

Outer surface interactions to drive cucurbit[8]uril-based supramolecular frameworks: possible application in gold recovery

Q[8]-based honeycomb-like frameworks could be obtained in [AuCl4] free aqueous HNO3 solution, aqueous HCl and HNO3 solutions that contain [AuCl4]. These frameworks exhibit a high selectivity for imprisoning [AuCl4].

Graphical abstract: Outer surface interactions to drive cucurbit[8]uril-based supramolecular frameworks: possible application in gold recovery
From the themed collection: Cucurbiturils and related cavitands
Communication

Cooperative enhancement of antibacterial activity of sanguinarine drug through p-sulfonatocalix[6]arene functionalized silver nanoparticles

The amelioration of antibacterial efficacy along with the reduced minimum inhibitory concentration (MIC) of sanguinarine (SGR) drug have been demonstrated through the uptake of SGR by p-sulfonatocalix[6]arene functionalized silver nanoparticles.

Graphical abstract: Cooperative enhancement of antibacterial activity of sanguinarine drug through p-sulfonatocalix[6]arene functionalized silver nanoparticles
From the themed collection: Cucurbiturils and related cavitands
Communication

pH clock instructed transient supramolecular peptide amphiphile and its vesicular assembly

A pH clock directed transient supramolecular peptide amphiphile and its vesicular assembly using ternary complexation of cucurbit[8]uril is displayed.

Graphical abstract: pH clock instructed transient supramolecular peptide amphiphile and its vesicular assembly
From the themed collection: Cucurbiturils and related cavitands
Communication

Cucurbit[7]uril promoted Fenton oxidation by modulating the redox property of catalysts

The redox property of a ferrocene derivative is modulated by cucurbit[7]uril, thus accelerating the catalytic oxidation of dye chromophores.

Graphical abstract: Cucurbit[7]uril promoted Fenton oxidation by modulating the redox property of catalysts
From the themed collection: Cucurbiturils and related cavitands
Communication

A supramolecular five-component relay switch that exposes the mechanistic competition of dissociative versus associative binding to cucurbiturils by ratiometric fluorescence monitoring

A putrescine derivative of aminomethyladamantane is established as a ditopic guest with two mutually exclusive binding sites for cucurbit[6]uril and cucurbit[7]uril.

Graphical abstract: A supramolecular five-component relay switch that exposes the mechanistic competition of dissociative versus associative binding to cucurbiturils by ratiometric fluorescence monitoring
From the themed collection: Cucurbiturils and related cavitands
Open Access Communication

Binding affinities of cucurbit[n]urils with cations

High binding constants of 19 inorganic cations with the cucurbit[n]uril homologues (CBn, n = 5, 6, 7, 8) in water were determined and the far-reaching consequences and interferences of the high affinities (millimolar to micromolar) are discussed.

Graphical abstract: Binding affinities of cucurbit[n]urils with cations
From the themed collection: Cucurbiturils and related cavitands
Communication

Mesoporous silica nanobeans dual-functionalized with AIEgens and leaning pillar[6]arene-based supramolecular switches for imaging and stimuli-responsive drug release

Dual-functionalized mesoporous silica nanobeans capable of GSH-dependent turn-on fluorescence and stimuli-responsive drug release are prepared for tumor inhibition and imaging.

Graphical abstract: Mesoporous silica nanobeans dual-functionalized with AIEgens and leaning pillar[6]arene-based supramolecular switches for imaging and stimuli-responsive drug release
From the themed collection: Cucurbiturils and related cavitands
Communication

A single-crystal-to-single-crystal transformation affording photochromic 3D MORF crystals

Metal–organic framework (MOF) type crystals in which rigid, viologen-based pillars are surrounded by cucurbit[7]uril (CB[7]) macrocycles are described.

Graphical abstract: A single-crystal-to-single-crystal transformation affording photochromic 3D MORF crystals
From the themed collection: Cucurbiturils and related cavitands
Communication

N-Doped holey carbon materials derived from a metal-free macrocycle cucurbit[6]uril assembly as an efficient electrocatalyst for the oxygen reduction reaction

The first example of the preparation of nitrogen-doped holey carbon (NHC) with abundant in-plane holes derived from a rigid macrocycle cucurbit[6]uril self-assembly is reported.

Graphical abstract: N-Doped holey carbon materials derived from a metal-free macrocycle cucurbit[6]uril assembly as an efficient electrocatalyst for the oxygen reduction reaction
From the themed collection: Cucurbiturils and related cavitands
Communication

Cucurbit[8]uril-based supramolecular nanocapsules with a multienzyme-cascade antioxidative effect

Supramolecular nanocapsules with both SOD and GPx activities were constructed by the ternary host–guest complexation of azobenzene (Azo) and methylviologen (MV) to cucurbit[8]uril (CB[8]) and the subsequent self-assembly.

Graphical abstract: Cucurbit[8]uril-based supramolecular nanocapsules with a multienzyme-cascade antioxidative effect
From the themed collection: Cucurbiturils and related cavitands
Communication

Unveiling the formation 1 : 2 supramolecular complexes between cucurbit[7]uril and a cationic calix[4]arene derivative

The formation of host–guest complexes between cucurbit[7]uril (CB7) and a tetracationic calix[4]arene derivative in the so-called cone conformation was investigated by 1H NMR, DOSY NMR, isothermal titration calorimetry and ESI-MS.

Graphical abstract: Unveiling the formation 1 : 2 supramolecular complexes between cucurbit[7]uril and a cationic calix[4]arene derivative
From the themed collection: Cucurbiturils and related cavitands
Communication

Gold nanorods with a noncovalently tailorable surface for multi-modality image-guided chemo-photothermal cancer therapy

Cucurbit[7]uril functionalized Au nanorods allowed noncovalently tailorable surface modification for image-guided, targeted chemo-photothermal cancer therapy in vitro and in vivo.

Graphical abstract: Gold nanorods with a noncovalently tailorable surface for multi-modality image-guided chemo-photothermal cancer therapy
From the themed collection: Cucurbiturils and related cavitands
Communication

Cucurbit[8]uril-mediated pseudo[2,3]rotaxanes

Cucurbit[8]uril-mediated pseudo[2,3]rotaxanes constrain chromophores into dimeric stacks with effective electron-delocalisation along the long-molecular axis.

Graphical abstract: Cucurbit[8]uril-mediated pseudo[2,3]rotaxanes
From the themed collection: Cucurbiturils and related cavitands
Communication

High affinity threading of a new tetralactam macrocycle in water by fluorescent deep-red and near-infrared squaraine dyes

Guest back-folding increases squaraine affinity for a new tetralactam macrocycle 370-fold in water.

Graphical abstract: High affinity threading of a new tetralactam macrocycle in water by fluorescent deep-red and near-infrared squaraine dyes
From the themed collection: Cucurbiturils and related cavitands
Communication

Templating conformations with cucurbiturils

The trans- and cis conformations of 5,5′-substituted 2,2′-dithiophenes can be stabilized when those are secured with two Cucurbit[8]uril macrocycles (CB[8]) on top of rigid 2,6- and 2,7-substituted naphthalenes, which respectively mimic the trans and cis conformations of the dithiophene.

Graphical abstract: Templating conformations with cucurbiturils
From the themed collection: Cucurbiturils and related cavitands
Communication

Decamethylcucurbit[5]uril based supramolecular assemblies as efficient electrocatalysts for the oxygen reduction reaction

A series of decamethylcucurbit[5]uril based supramolecular assemblies were successfully synthesized and explored as efficient electrocatalysts towards the oxygen reduction reaction.

Graphical abstract: Decamethylcucurbit[5]uril based supramolecular assemblies as efficient electrocatalysts for the oxygen reduction reaction
From the themed collection: Cucurbiturils and related cavitands
Communication

Reversible hydrogel dynamics by physical–chemical crosslink photoswitching using a supramolecular macrocycle template

Host–guest supramolecular hydrogels are prepared from light-responsive guests within a CB[8] cavitand, and the complex catalyzes reversible guest photodimerization.

Graphical abstract: Reversible hydrogel dynamics by physical–chemical crosslink photoswitching using a supramolecular macrocycle template
From the themed collection: Cucurbiturils and related cavitands
Communication

Ratiometric DNA sensing with a host–guest FRET pair

A host–guest FRET pair based on a carboxyfluorescein-labelled cucurbit[7]uril and DAPI was developed to sense DNA ratiometrically.

Graphical abstract: Ratiometric DNA sensing with a host–guest FRET pair
25 items

About this collection

Cucurbiturils are water-soluble organic cavitands with exceptional guest-binding properties. Interest in the synthesis, supramolecular chemistry, and uses of cucurbiturils and related cavitands has exploded since the early 2000s, with applications including sensing, separations, drug delivery, catalysis, molecular recognition, and materials science. Research in these diverse areas underscores the unique characteristics of cucurbiturils that enable aqueous molecular recognition over an unprecedented range of binding affinities.
Following the 6th International Conference on Cucurbiturils (ICCB 2019) at Ohio University, our aim in publishing this special issue, Guest Edited by Adam Urbach (Trinity University), Eric Masson (Ohio University), and Kimoon Kim (POSTECH), is to highlight the latest developments in the chemistry of cucurbiturils and related cavitands.  In particular, we aim to highlight synthetic methods for new host compounds, characterization of guest-binding properties, and supramolecular applications ranging from materials science to chemical biology.

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