Themed collection Cucurbiturils and related cavitands
Glycoluril derived cucurbituril analogues and the emergence of the most recent example: tiarauril
Cucurbituril analogues can bear some of the chemical and physical characteristics of their parental origin and are derived wholly or in part from glycolurils (including homologues).
Modelling haemoproteins: porphyrins and cyclodextrins as sources of inspiration
Associations of hydrophobic cavities with porphyrin derivatives used to mimic haemoprotein structures are featured in this article and may inspire innovative research in the field of cucurbiturils.
Cucurbit[n]uril-based amphiphiles that self-assemble into functional nanomaterials for therapeutics
In this feature article, the two types (molecular amphiphile and supramolecular amphiphile) of CB-based amphiphiles, their self-assemblies and their applications for useful nanotherapeutics and theranostics are presented with future perspectives.
Supra-blot: an accurate and reliable assay for detecting target proteins with a synthetic host molecule–enzyme hybrid
A new way to detect target proteins is developed using a high-affinity host–guest interaction for a wide variety of biological samples including bacteria and mammalian cells.
Engineered assembly of a protein–cucurbituril biohybrid
Additional Q7 binding sites drive protein aggregation in solution and statistical disorder in the crystalline biohybrid suggest new possibilities for protein-based materials.
Supramolecular chirogenesis in zinc porphyrins by enantiopure hemicucurbit[n]urils (n = 6, 8)
Chiral cyclohexanohemicucurbit[n]urils with multiple interaction sites induce chirality on planar zinc porphyrins and bind up to three porphyrin molecules.
Dynamic host–guest interaction enables autonomous single molecule blinking and super-resolution imaging
Specific yet dynamic interaction in cucurbituril (CB) system was used to obtain programmable fluorescence blinking with necessary brightness and frequency to enable two-dimensional (2D) and 3D super-resolution imaging of proteins in cells.
Outer surface interactions to drive cucurbituril-based supramolecular frameworks: possible application in gold recovery
Q-based honeycomb-like frameworks could be obtained in [AuCl4]− free aqueous HNO3 solution, aqueous HCl and HNO3 solutions that contain [AuCl4]−. These frameworks exhibit a high selectivity for imprisoning [AuCl4]−.
Cooperative enhancement of antibacterial activity of sanguinarine drug through p-sulfonatocalixarene functionalized silver nanoparticles
The amelioration of antibacterial efficacy along with the reduced minimum inhibitory concentration (MIC) of sanguinarine (SGR) drug have been demonstrated through the uptake of SGR by p-sulfonatocalixarene functionalized silver nanoparticles.
pH clock instructed transient supramolecular peptide amphiphile and its vesicular assembly
A pH clock directed transient supramolecular peptide amphiphile and its vesicular assembly using ternary complexation of cucurbituril is displayed.
Cucurbituril promoted Fenton oxidation by modulating the redox property of catalysts
The redox property of a ferrocene derivative is modulated by cucurbituril, thus accelerating the catalytic oxidation of dye chromophores.
A supramolecular five-component relay switch that exposes the mechanistic competition of dissociative versus associative binding to cucurbiturils by ratiometric fluorescence monitoring
A putrescine derivative of aminomethyladamantane is established as a ditopic guest with two mutually exclusive binding sites for cucurbituril and cucurbituril.
Binding affinities of cucurbit[n]urils with cations
High binding constants of 19 inorganic cations with the cucurbit[n]uril homologues (CBn, n = 5, 6, 7, 8) in water were determined and the far-reaching consequences and interferences of the high affinities (millimolar to micromolar) are discussed.
Mesoporous silica nanobeans dual-functionalized with AIEgens and leaning pillararene-based supramolecular switches for imaging and stimuli-responsive drug release
Dual-functionalized mesoporous silica nanobeans capable of GSH-dependent turn-on fluorescence and stimuli-responsive drug release are prepared for tumor inhibition and imaging.
A single-crystal-to-single-crystal transformation affording photochromic 3D MORF crystals
Metal–organic framework (MOF) type crystals in which rigid, viologen-based pillars are surrounded by cucurbituril (CB) macrocycles are described.
N-Doped holey carbon materials derived from a metal-free macrocycle cucurbituril assembly as an efficient electrocatalyst for the oxygen reduction reaction
The first example of the preparation of nitrogen-doped holey carbon (NHC) with abundant in-plane holes derived from a rigid macrocycle cucurbituril self-assembly is reported.
Cucurbituril-based supramolecular nanocapsules with a multienzyme-cascade antioxidative effect
Supramolecular nanocapsules with both SOD and GPx activities were constructed by the ternary host–guest complexation of azobenzene (Azo) and methylviologen (MV) to cucurbituril (CB) and the subsequent self-assembly.
Unveiling the formation 1 : 2 supramolecular complexes between cucurbituril and a cationic calixarene derivative
The formation of host–guest complexes between cucurbituril (CB7) and a tetracationic calixarene derivative in the so-called cone conformation was investigated by 1H NMR, DOSY NMR, isothermal titration calorimetry and ESI-MS.
Gold nanorods with a noncovalently tailorable surface for multi-modality image-guided chemo-photothermal cancer therapy
Cucurbituril functionalized Au nanorods allowed noncovalently tailorable surface modification for image-guided, targeted chemo-photothermal cancer therapy in vitro and in vivo.
Cucurbituril-mediated pseudo[2,3]rotaxanes constrain chromophores into dimeric stacks with effective electron-delocalisation along the long-molecular axis.
High affinity threading of a new tetralactam macrocycle in water by fluorescent deep-red and near-infrared squaraine dyes
Guest back-folding increases squaraine affinity for a new tetralactam macrocycle 370-fold in water.
Templating conformations with cucurbiturils
The trans- and cis conformations of 5,5′-substituted 2,2′-dithiophenes can be stabilized when those are secured with two Cucurbituril macrocycles (CB) on top of rigid 2,6- and 2,7-substituted naphthalenes, which respectively mimic the trans and cis conformations of the dithiophene.
Decamethylcucurbituril based supramolecular assemblies as efficient electrocatalysts for the oxygen reduction reaction
A series of decamethylcucurbituril based supramolecular assemblies were successfully synthesized and explored as efficient electrocatalysts towards the oxygen reduction reaction.
Reversible hydrogel dynamics by physical–chemical crosslink photoswitching using a supramolecular macrocycle template
Host–guest supramolecular hydrogels are prepared from light-responsive guests within a CB cavitand, and the complex catalyzes reversible guest photodimerization.
Ratiometric DNA sensing with a host–guest FRET pair
A host–guest FRET pair based on a carboxyfluorescein-labelled cucurbituril and DAPI was developed to sense DNA ratiometrically.