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Issue 5, 2019
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Ratiometric DNA sensing with a host–guest FRET pair

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Abstract

A supramolecular host–guest FRET pair based on a carboxyfluorescein-labelled cucurbit[7]uril (CB7-CF, as acceptor) and the fluorescent dye 4′,6-diamidino-2-phenylindole (DAPI, as donor) is developed for sensing of DNA. In comparison to the commercial DNA staining dye SYBR Green I, the new chemosensing ensemble offers dual-emission signals, which allows a linear ratiometric response over a wide concentration range.

Graphical abstract: Ratiometric DNA sensing with a host–guest FRET pair

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Publication details

The article was received on 16 Nov 2018, accepted on 10 Dec 2018 and first published on 10 Dec 2018


Article type: Communication
DOI: 10.1039/C8CC09126A
Chem. Commun., 2019,55, 671-674

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    Ratiometric DNA sensing with a host–guest FRET pair

    S. Zhang, K. I. Assaf, C. Huang, A. Hennig and W. M. Nau, Chem. Commun., 2019, 55, 671
    DOI: 10.1039/C8CC09126A

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