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Dynamic host–guest interaction enables autonomous single molecule blinking and super-resolution imaging

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Abstract

Synthetic host–guest complexes are inherently dynamic as they employ weak and reversible noncovalent interactions for their recognition processes. We strategically exploited dynamic supramolecular recognition between fluorescently labeled guest molecules to complementary cucurbit[7]uril hosts to obtain stochastic switching between fluorescence ON- and OFF-states, enabling PAINT-based nanoscopic imaging in cells and tissues.

Graphical abstract: Dynamic host–guest interaction enables autonomous single molecule blinking and super-resolution imaging

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Publication details

The article was received on 12 Sep 2019, accepted on 29 Oct 2019 and first published on 06 Nov 2019


Article type: Communication
DOI: 10.1039/C9CC07153A
Chem. Commun., 2019, Advance Article

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    Dynamic host–guest interaction enables autonomous single molecule blinking and super-resolution imaging

    R. Sasmal, N. Das Saha, F. Schueder, D. Joshi, V. Sheeba, R. Jungmann and S. S. Agasti, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC07153A

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