Themed collection Biomaterials Science Most Popular 2020
Overview of the application of inorganic nanomaterials in cancer photothermal therapy
Cancer photothermal therapy (PTT) has captured the attention of researchers worldwide due to its localized and trigger-activated therapeutic effect.
Advances in self-assembled injectable hydrogels for cancer therapy
Non-specific toxicity of chemotherapeutics and evolution of malignant tumors against them are major challenges for existing cancer chemotherapeutic regimens.
Rational design and latest advances of polysaccharide-based hydrogels for wound healing
This review presented the crucial design considerations and current state of polysaccharide-based hydrogels as wound dressings. The commonly used crosslinking techniques are also discussed in detail.
Bioinspired surfaces with wettability: biomolecule adhesion behaviors
This contribution reviewed the influences of surface extreme wettability on biomolecule adhesion behaviors, which is expected to bring a new perspective in the application of wettability to biomaterials.
Cell membrane biomimetic nanoparticles for inflammation and cancer targeting in drug delivery
Cell membrane coated nanoparticles have been designed for inflammation and cancer therapy. An array of cell membranes from cell library were extracted and leveraged to coat a variety of nanoparticles for different diseases.
The nanostructured secretome
The term secretome should be expanded to also include the great variety of nanoparticles secreted by cells into the extracellular space, which ranges from lipoproteins of a few nanometers to extracellular vesicles of hundreds of nanometers.
Meta-biomaterials are designer biomaterials with unusual and even unprecedented properties that primarily originate from their geometrical designs at different (usually smaller) length scales.
Rapid harvesting of stem cell sheets by thermoresponsive bulk poly(N-isopropylacrylamide) (PNIPAAm) nanotopography
A novel concept of utilizing bulk PNIPAAm substrate nanotopography for rapid harvest of human bone marrow mesenchymal stem cells (hBMSCs) sheet. The created nanotogporaphy significantly accelerated the formation of hBMSC layers and eased the detachment of hBMSC sheets.
Thermostabilization of viruses via complex coacervation
Complex coacervation shows promise as a strategy to improve the thermal stability of viruses for use in vaccine formulations.
An alpha/beta chimeric peptide molecular brush for eradicating MRSA biofilms and persister cells to mitigate antimicrobial resistance
An α/β chimeric polypeptide molecular brush shows excellent performance in eradicating established biofilms, persister cells, and clinically isolated multi-drug resistant Gram-positive bacteria.
Amyloid-like protein aggregates combining antifouling with antibacterial activity
A new class of biopolymer coating based on amyloid-like protein aggregates is reported to combine both antifouling and antibacterial activity.
The unique potency of Cowpea mosaic virus (CPMV) in situ cancer vaccine
Plant viral nanoparticle CPMV outperforms other icosahedral viruses as an in situ vaccine for cancer immunotherapy.
Injectable postoperative enzyme-responsive hydrogels for reversing temozolomide resistance and reducing local recurrence after glioma operation
Glioma is the most aggressive primary malignant brain tumor.
Immune-modulatory alginate protects mesenchymal stem cells for sustained delivery of reparative factors to ischemic myocardium
Immune modulatory alginate encapsulation platform can be used in the pericardial space to provide enhanced therapeutic efficacy to the heart.
Design, development, testing at ISO standards and in vivo feasibility study of a novel polymeric heart valve prosthesis
A novel polymeric heart valve shows durability equivalent to 25 years in accelerated bench testing, in vitro hydrodynamics equivalent to existing bioprosthetic valves; and good performance in a small acute feasibility study in sheep.
Scaffold channel size influences stem cell differentiation pathway in 3-D printed silica hybrid scaffolds for cartilage regeneration
We report that 3-D printed scaffold channel size can direct bone marrow derived stem cell differentiation, e.g. ∼200–250 μm channels promote hyaline-like cartilage matrix production.
The rapid photoresponsive bacteria-killing of Cu-doped MoS2
This material of Cu doped MoS2 can produce reactive oxygen species and photothermal under 660 nm light, thus achieving a rapid bacterial effect. Which is a kind of good photothermal and photodynamic material.
Nanoscale insight into the degradation mechanisms of the cartilage articulating surface preceding OA
Osteoarthritis (OA) is a degenerative disease and leading cause of disability globally. We report the a fundamental study of the mechanisms underlying deterioration of hydrated cartilage in the presence of elevated calcium content preceding OA.
Long-term delivery of alendronate through an injectable tetra-PEG hydrogel to promote osteoporosis therapy
An alendronate-loaded tetra-PEG hydrogel, as an injectable and effective drug carrier, regulates the optimized release of therapeutic cargoes to promote osteoporosis therapy and bone regeneration.
Delivery of dual miRNA through CD44-targeted mesoporous silica nanoparticles for enhanced and effective triple-negative breast cancer therapy
Cationic Mesoporous silica Nanoparticle coated with hyaluronic acid conjugated polymer (HA-Dual miRNA Np) facilitated enhanced dual miRNA loading, efficient delivery and significantly inhibited tumor growth as well as retarded metastasis in triple-negative breast cancer.
Construction of a tumor microenvironment pH-responsive cleavable PEGylated hyaluronic acid nano-drug delivery system for colorectal cancer treatment
To improve the tumor cell active targeting, uptake efficiency and circulation time of doxorubicin (DOX) in vivo. Herein, we constructed a cleavable PEGylated hyaluronic acid nano-drug delivery system (HA–mPEG2k–DOX) based on pH-responsive imine bond.
Fabrication of strong hydrogen-bonding induced coacervate adhesive hydrogels with antibacterial and hemostatic activities
A supramolecular polymer adhesive hydrogel prepared by a simple two-component mixing method exhibits strong adhesion to different substrates, and antibacterial and hemostatic activities.
Enhancing doxorubicin anticancer activity with a novel polymeric platform photoreleasing nitric oxide
Combination of Doxorubicin with light-regulated NO release achieved through formulation strategy of tailored polymeric conjugate nanoparticles may open new treatment modalities to improve cancer therapies.
Tannic acid-based nanogel as an efficient anti-inflammatory agent
Biologically produced reactive oxygen species (ROS) are important signaling molecules in the human body.
Biomimetic drug delivery platforms based on mesenchymal stem cells impregnated with light-responsive submicron sized carriers
Synthetic organic and inorganic carriers often have limitations associated with problematic targeting ability or non-optimized pharmacokinetics, and, therefore, they have restricted therapeutic potential.
Chemobrionic structures in tissue engineering: self-assembling calcium phosphate tubes as cellular scaffolds
A diverse range of complex patterns and mineralised hierarchical microstructures can be derived from chemobrionic systems. In this work, we explore chemobrionic calcium phosphate tubes as cellular scaffolds.
A water soluble carbazolyl-BODIPY photosensitizer with an orthogonal D–A structure for photodynamic therapy in living cells and zebrafish
A photosensitizer Cz-BODIPY with an orthogonal D–A structure was developed and displayed promising potential in real PDT application.
Nanogel hybrid assembly for exosome intracellular delivery: effects on endocytosis and fusion by exosome surface polymer engineering
Surface polymer engineering was applied with a carrier of exosomes, namely, the amphiphilic cationic CHP (cCHP) nanogel, to improve the delivery of exosome content by forming complexes with the exosomes.
A triple chain polycationic peptide-mimicking amphiphile – efficient DNA-transfer without co-lipids
DiTT4 lipoplexes have exhibited excellent transfection efficiency in a complex tissue together with a biocompatibility profile that makes it a prospective vehicle for gene delivery.
Antibacterial and hydroxyapatite-forming coating for biomedical implants based on polypeptide-functionalized titania nanospikes
The immobilization of mussel-inspired polypeptide onto biomimetic titania nanospike coating enhanced its antibacterial ability and bioactivity, thus holding great promise for utilization for orthopedic and dental implants.
About this collection
This online collection features some of the most cited, most downloaded and most shared articles published in Biomaterials Science during 2020. Thank you to our authors, reviewers and readers for your ongoing support.