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Themed collection Biomaterials Science Most Popular 2020

30 items
Review Article

Overview of the application of inorganic nanomaterials in cancer photothermal therapy

Cancer photothermal therapy (PTT) has captured the attention of researchers worldwide due to its localized and trigger-activated therapeutic effect.

Graphical abstract: Overview of the application of inorganic nanomaterials in cancer photothermal therapy
From the themed collection: Biomaterials Science Most Popular 2020
Review Article

Advances in self-assembled injectable hydrogels for cancer therapy

Non-specific toxicity of chemotherapeutics and evolution of malignant tumors against them are major challenges for existing cancer chemotherapeutic regimens.

Graphical abstract: Advances in self-assembled injectable hydrogels for cancer therapy
From the themed collection: Biomaterials Science Most Popular 2020
Review Article

Rational design and latest advances of polysaccharide-based hydrogels for wound healing

This review presented the crucial design considerations and current state of polysaccharide-based hydrogels as wound dressings. The commonly used crosslinking techniques are also discussed in detail.

Graphical abstract: Rational design and latest advances of polysaccharide-based hydrogels for wound healing
From the themed collection: Biomaterials Science Most Popular 2020
Review Article

Bioinspired surfaces with wettability: biomolecule adhesion behaviors

This contribution reviewed the influences of surface extreme wettability on biomolecule adhesion behaviors, which is expected to bring a new perspective in the application of wettability to biomaterials.

Graphical abstract: Bioinspired surfaces with wettability: biomolecule adhesion behaviors
From the themed collection: Biomaterials Science Most Popular 2020
Review Article

Cell membrane biomimetic nanoparticles for inflammation and cancer targeting in drug delivery

Cell membrane coated nanoparticles have been designed for inflammation and cancer therapy. An array of cell membranes from cell library were extracted and leveraged to coat a variety of nanoparticles for different diseases.

Graphical abstract: Cell membrane biomimetic nanoparticles for inflammation and cancer targeting in drug delivery
From the themed collection: Biomaterials Science Most Popular 2020
Review Article

The nanostructured secretome

The term secretome should be expanded to also include the great variety of nanoparticles secreted by cells into the extracellular space, which ranges from lipoproteins of a few nanometers to extracellular vesicles of hundreds of nanometers.

Graphical abstract: The nanostructured secretome
From the themed collection: Biomaterials Science Most Popular 2020
Open Access Review Article

Meta-biomaterials

Meta-biomaterials are designer biomaterials with unusual and even unprecedented properties that primarily originate from their geometrical designs at different (usually smaller) length scales.

Graphical abstract: Meta-biomaterials
From the themed collection: Biomaterials Science Most Popular 2020
Communication

Rapid harvesting of stem cell sheets by thermoresponsive bulk poly(N-isopropylacrylamide) (PNIPAAm) nanotopography

A novel concept of utilizing bulk PNIPAAm substrate nanotopography for rapid harvest of human bone marrow mesenchymal stem cells (hBMSCs) sheet. The created nanotogporaphy significantly accelerated the formation of hBMSC layers and eased the detachment of hBMSC sheets.

Graphical abstract: Rapid harvesting of stem cell sheets by thermoresponsive bulk poly(N-isopropylacrylamide) (PNIPAAm) nanotopography
From the themed collection: Biomaterials Science Most Popular 2020
Open Access Paper

Thermostabilization of viruses via complex coacervation

Complex coacervation shows promise as a strategy to improve the thermal stability of viruses for use in vaccine formulations.

Graphical abstract: Thermostabilization of viruses via complex coacervation
Paper

An alpha/beta chimeric peptide molecular brush for eradicating MRSA biofilms and persister cells to mitigate antimicrobial resistance

An α/β chimeric polypeptide molecular brush shows excellent performance in eradicating established biofilms, persister cells, and clinically isolated multi-drug resistant Gram-positive bacteria.

Graphical abstract: An alpha/beta chimeric peptide molecular brush for eradicating MRSA biofilms and persister cells to mitigate antimicrobial resistance
From the themed collection: Antibacterial Biomaterials
Paper

Amyloid-like protein aggregates combining antifouling with antibacterial activity

A new class of biopolymer coating based on amyloid-like protein aggregates is reported to combine both antifouling and antibacterial activity.

Graphical abstract: Amyloid-like protein aggregates combining antifouling with antibacterial activity
From the themed collection: Antibacterial Biomaterials
Paper

The unique potency of Cowpea mosaic virus (CPMV) in situ cancer vaccine

Plant viral nanoparticle CPMV outperforms other icosahedral viruses as an in situ vaccine for cancer immunotherapy.

Graphical abstract: The unique potency of Cowpea mosaic virus (CPMV) in situ cancer vaccine
From the themed collection: Biomaterials Science Most Popular 2020
Paper

Injectable postoperative enzyme-responsive hydrogels for reversing temozolomide resistance and reducing local recurrence after glioma operation

Glioma is the most aggressive primary malignant brain tumor.

Graphical abstract: Injectable postoperative enzyme-responsive hydrogels for reversing temozolomide resistance and reducing local recurrence after glioma operation
From the themed collection: Biomaterials Science Recent HOT Articles
Paper

Immune-modulatory alginate protects mesenchymal stem cells for sustained delivery of reparative factors to ischemic myocardium

Immune modulatory alginate encapsulation platform can be used in the pericardial space to provide enhanced therapeutic efficacy to the heart.

Graphical abstract: Immune-modulatory alginate protects mesenchymal stem cells for sustained delivery of reparative factors to ischemic myocardium
Open Access Paper

Design, development, testing at ISO standards and in vivo feasibility study of a novel polymeric heart valve prosthesis

A novel polymeric heart valve shows durability equivalent to 25 years in accelerated bench testing, in vitro hydrodynamics equivalent to existing bioprosthetic valves; and good performance in a small acute feasibility study in sheep.

Graphical abstract: Design, development, testing at ISO standards and in vivo feasibility study of a novel polymeric heart valve prosthesis
From the themed collection: Biomaterials Science Most Popular 2020
Open Access Paper

Scaffold channel size influences stem cell differentiation pathway in 3-D printed silica hybrid scaffolds for cartilage regeneration

We report that 3-D printed scaffold channel size can direct bone marrow derived stem cell differentiation, e.g. ∼200–250 μm channels promote hyaline-like cartilage matrix production.

Graphical abstract: Scaffold channel size influences stem cell differentiation pathway in 3-D printed silica hybrid scaffolds for cartilage regeneration
From the themed collection: Biomaterials Science Most Popular 2020
Paper

The rapid photoresponsive bacteria-killing of Cu-doped MoS2

This material of Cu doped MoS2 can produce reactive oxygen species and photothermal under 660 nm light, thus achieving a rapid bacterial effect. Which is a kind of good photothermal and photodynamic material.

Graphical abstract: The rapid photoresponsive bacteria-killing of Cu-doped MoS2
From the themed collection: Antibacterial Biomaterials
Paper

Nanoscale insight into the degradation mechanisms of the cartilage articulating surface preceding OA

Osteoarthritis (OA) is a degenerative disease and leading cause of disability globally. We report the a fundamental study of the mechanisms underlying deterioration of hydrated cartilage in the presence of elevated calcium content preceding OA.

Graphical abstract: Nanoscale insight into the degradation mechanisms of the cartilage articulating surface preceding OA
From the themed collection: Biomaterials Science Most Popular 2020
Paper

Long-term delivery of alendronate through an injectable tetra-PEG hydrogel to promote osteoporosis therapy

An alendronate-loaded tetra-PEG hydrogel, as an injectable and effective drug carrier, regulates the optimized release of therapeutic cargoes to promote osteoporosis therapy and bone regeneration.

Graphical abstract: Long-term delivery of alendronate through an injectable tetra-PEG hydrogel to promote osteoporosis therapy
From the themed collection: Biomaterials Science Most Popular 2020
Paper

Delivery of dual miRNA through CD44-targeted mesoporous silica nanoparticles for enhanced and effective triple-negative breast cancer therapy

Cationic Mesoporous silica Nanoparticle coated with hyaluronic acid conjugated polymer (HA-Dual miRNA Np) facilitated enhanced dual miRNA loading, efficient delivery and significantly inhibited tumor growth as well as retarded metastasis in triple-negative breast cancer.

Graphical abstract: Delivery of dual miRNA through CD44-targeted mesoporous silica nanoparticles for enhanced and effective triple-negative breast cancer therapy
From the themed collection: Biomaterials Science Most Popular 2020
Paper

Construction of a tumor microenvironment pH-responsive cleavable PEGylated hyaluronic acid nano-drug delivery system for colorectal cancer treatment

To improve the tumor cell active targeting, uptake efficiency and circulation time of doxorubicin (DOX) in vivo. Herein, we constructed a cleavable PEGylated hyaluronic acid nano-drug delivery system (HA–mPEG2k–DOX) based on pH-responsive imine bond.

Graphical abstract: Construction of a tumor microenvironment pH-responsive cleavable PEGylated hyaluronic acid nano-drug delivery system for colorectal cancer treatment
From the themed collection: Biomaterials Science Most Popular 2020
Paper

Fabrication of strong hydrogen-bonding induced coacervate adhesive hydrogels with antibacterial and hemostatic activities

A supramolecular polymer adhesive hydrogel prepared by a simple two-component mixing method exhibits strong adhesion to different substrates, and antibacterial and hemostatic activities.

Graphical abstract: Fabrication of strong hydrogen-bonding induced coacervate adhesive hydrogels with antibacterial and hemostatic activities
From the themed collection: Biomaterials Science Most Popular 2020
Paper

Enhancing doxorubicin anticancer activity with a novel polymeric platform photoreleasing nitric oxide

Combination of Doxorubicin with light-regulated NO release achieved through formulation strategy of tailored polymeric conjugate nanoparticles may open new treatment modalities to improve cancer therapies.

Graphical abstract: Enhancing doxorubicin anticancer activity with a novel polymeric platform photoreleasing nitric oxide
From the themed collection: Biomaterials Science Most Popular 2020
Paper

Tannic acid-based nanogel as an efficient anti-inflammatory agent

Biologically produced reactive oxygen species (ROS) are important signaling molecules in the human body.

Graphical abstract: Tannic acid-based nanogel as an efficient anti-inflammatory agent
From the themed collection: Biomaterials Science Most Popular 2020
Paper

Biomimetic drug delivery platforms based on mesenchymal stem cells impregnated with light-responsive submicron sized carriers

Synthetic organic and inorganic carriers often have limitations associated with problematic targeting ability or non-optimized pharmacokinetics, and, therefore, they have restricted therapeutic potential.

Graphical abstract: Biomimetic drug delivery platforms based on mesenchymal stem cells impregnated with light-responsive submicron sized carriers
From the themed collection: Biomaterials Science Most Popular 2020
Open Access Paper

Chemobrionic structures in tissue engineering: self-assembling calcium phosphate tubes as cellular scaffolds

A diverse range of complex patterns and mineralised hierarchical microstructures can be derived from chemobrionic systems. In this work, we explore chemobrionic calcium phosphate tubes as cellular scaffolds.

Graphical abstract: Chemobrionic structures in tissue engineering: self-assembling calcium phosphate tubes as cellular scaffolds
From the themed collection: Biomaterials Science Most Popular 2020
Paper

A water soluble carbazolyl-BODIPY photosensitizer with an orthogonal D–A structure for photodynamic therapy in living cells and zebrafish

A photosensitizer Cz-BODIPY with an orthogonal D–A structure was developed and displayed promising potential in real PDT application.

Graphical abstract: A water soluble carbazolyl-BODIPY photosensitizer with an orthogonal D–A structure for photodynamic therapy in living cells and zebrafish
From the themed collection: Biomaterials Science Most Popular 2020
Paper

Nanogel hybrid assembly for exosome intracellular delivery: effects on endocytosis and fusion by exosome surface polymer engineering

Surface polymer engineering was applied with a carrier of exosomes, namely, the amphiphilic cationic CHP (cCHP) nanogel, to improve the delivery of exosome content by forming complexes with the exosomes.

Graphical abstract: Nanogel hybrid assembly for exosome intracellular delivery: effects on endocytosis and fusion by exosome surface polymer engineering
From the themed collection: Biomaterials Science Most Popular 2020
Paper

A triple chain polycationic peptide-mimicking amphiphile – efficient DNA-transfer without co-lipids

DiTT4 lipoplexes have exhibited excellent transfection efficiency in a complex tissue together with a biocompatibility profile that makes it a prospective vehicle for gene delivery.

Graphical abstract: A triple chain polycationic peptide-mimicking amphiphile – efficient DNA-transfer without co-lipids
From the themed collection: Biomaterials Science Most Popular 2020
Paper

Antibacterial and hydroxyapatite-forming coating for biomedical implants based on polypeptide-functionalized titania nanospikes

The immobilization of mussel-inspired polypeptide onto biomimetic titania nanospike coating enhanced its antibacterial ability and bioactivity, thus holding great promise for utilization for orthopedic and dental implants.

Graphical abstract: Antibacterial and hydroxyapatite-forming coating for biomedical implants based on polypeptide-functionalized titania nanospikes
From the themed collection: Biomaterials Science Most Popular 2020
30 items

About this collection

This online collection features some of the most cited, most downloaded and most shared articles published in Biomaterials Science during 2020. Thank you to our authors, reviewers and readers for your ongoing support.

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