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Themed collection Bioanalytical sensors for real world applications

17 items
Critical Review

From the beaker to the body: translational challenges for electrochemical, aptamer-based sensors

The ultimate goal of implantable electrochemical, aptamer-based (E-AB) sensors is to enable the continuous and precise monitoring of clinically and physiologically important targets in the body for prolonged periods.

Graphical abstract: From the beaker to the body: translational challenges for electrochemical, aptamer-based sensors
Communication

A flexible and highly sensitive nitrite sensor enabled by interconnected 3D porous polyaniline/carbon nanotube conductive hydrogels

A flexible and highly sensitive nitrite sensor based on PANI–CNT hydrogels.

Graphical abstract: A flexible and highly sensitive nitrite sensor enabled by interconnected 3D porous polyaniline/carbon nanotube conductive hydrogels
Paper

Optimization of paper-based nanoparticle immunoassays for direct detection of the bacterial pathogen V. parahaemolyticus in oyster hemolymph

The detection of foodborne pathogens is critical for disease control and infection prevention, especially in seafood consumed raw or undercooked.

Graphical abstract: Optimization of paper-based nanoparticle immunoassays for direct detection of the bacterial pathogen V. parahaemolyticus in oyster hemolymph
Paper

Optimization of graphene oxide-modified carbon-fiber microelectrode for dopamine detection

Graphene oxide increases the sensitivity of carbon electrodes, facilitating dopamine detection in brain slices.

Graphical abstract: Optimization of graphene oxide-modified carbon-fiber microelectrode for dopamine detection
Paper

Electrochemical detection of bovine immunoglobulins G to determine passive transfer of antibodies to calves

Bovine antibodies cannot pass the placental barrier and must be absorbed from colostrum postpartum. Monitoring of IgG absorption in calves is critical in the first 12 hours of life. Novel sensors are presented to measure this transfer process on-farm.

Graphical abstract: Electrochemical detection of bovine immunoglobulins G to determine passive transfer of antibodies to calves
Paper

A high-throughput plasmonic tongue using an aggregation assay and nonspecific interactions: classification of taste profiles in maple syrup

A simple colorimetric test detects off-flavour profiles of maple syrups in minutes, which are detectable by the naked eye.

Graphical abstract: A high-throughput plasmonic tongue using an aggregation assay and nonspecific interactions: classification of taste profiles in maple syrup
Paper

Development and validation of a real-time microelectrochemical sensor for clinical monitoring of tissue oxygenation/perfusion

Oxygen is critically important to tissue viability and there is increasing demand for its reliable real-time clinical monitoring in order to prevent, diagnose and treat several pathological disorders, including hypoxia, stroke and reperfusion injury.

Graphical abstract: Development and validation of a real-time microelectrochemical sensor for clinical monitoring of tissue oxygenation/perfusion
Paper

Development of a paper-immobilized yeast biosensor for the detection of physiological concentrations of doxycycline in technology-limited settings

To combat pharmaceutical counterfeiting in low- and middle-income countries (LMIC), there is a need for improved low-cost, portable methods that monitor pharmaceutical concentrations relevant to dosage forms and physiological fluids.

Graphical abstract: Development of a paper-immobilized yeast biosensor for the detection of physiological concentrations of doxycycline in technology-limited settings
Paper

Towards simultaneous quantification of protease inhibitors and inflammatory biomarkers in serum for people living with HIV

Detecting small and big molecules together: simultaneous quantification of protease inhibitor (DRV) and inflammatory biomarker in serum by Arrayed Imaging Reflectometry (AIR).

Graphical abstract: Towards simultaneous quantification of protease inhibitors and inflammatory biomarkers in serum for people living with HIV
Paper

Facile fluorescence strategy for sensitive detection of microcystin-LR based on dsDNA-templated copper nanoclusters

We developed a simple, sensitive, low-cost and label-free method to detect microcystin-leucine-arginine (MC-LR) using double-strand DNA-templated copper nanoclusters (dsDNA-CuNCs) as fluorescent probes.

Graphical abstract: Facile fluorescence strategy for sensitive detection of microcystin-LR based on dsDNA-templated copper nanoclusters
Paper

Optical nanosensors for in vivo physiological chloride detection for monitoring cystic fibrosis treatment

Endogenous chloride fluctuations were successfully monitored in real-time using optode-based nanosensors during pharmacological treatment in a cystic fibrosis mouse model.

Graphical abstract: Optical nanosensors for in vivo physiological chloride detection for monitoring cystic fibrosis treatment
Paper

A multicolor multiplex lateral flow assay for high-sensitivity analyte detection using persistent luminescent nanophosphors

Multicolor multiplex lateral flow assay using persistent luminescent nanophosphors as reporters.

Graphical abstract: A multicolor multiplex lateral flow assay for high-sensitivity analyte detection using persistent luminescent nanophosphors
Paper

In situ hemolysis in a three-dimensional paper-based device for quantification of intraerythrocytic analytes

Quantitative in situ hemolysis is achieved for samples of whole blood using a chemical treatment without additional user-steps or sample preparation.

Graphical abstract: In situ hemolysis in a three-dimensional paper-based device for quantification of intraerythrocytic analytes
Paper

Generating linear oxygen gradients across 3D cell cultures with block-layered oxygen controlled chips (BLOCCs)

BLOCCs are readily assembled structures of laser cut acrylic and silicone, capable of imposing physiologically relevant oxygen gradients across 3D cell cultures. With sensors and cell-based readouts, we quantified cell-microenvironment relationships.

Graphical abstract: Generating linear oxygen gradients across 3D cell cultures with block-layered oxygen controlled chips (BLOCCs)
Paper

Lactate monitoring in droplet microfluidics: a cautionary tale in assay miniaturisation

We present the development of a droplet-based device for real-time continuous lactate measurement, highlighting how protocols from established homogeneous enzymatic assays require careful re-optimisation before transferring to microfluidic systems.

Graphical abstract: Lactate monitoring in droplet microfluidics: a cautionary tale in assay miniaturisation
Paper

Lab on paper: assay of beta-lactam pharmaceuticals by redox titration

This paper test card can identify ampicillin or amoxicillin formulations that contain <90% of the stated API content.

Graphical abstract: Lab on paper: assay of beta-lactam pharmaceuticals by redox titration
Paper

Detection of degraded, adulterated, and falsified ceftriaxone using paper analytical devices

A paper test card can distinguish good quality ceftriaxone from ceftriaxone that has been thermally degraded, adulterated, or falsified.

Graphical abstract: Detection of degraded, adulterated, and falsified ceftriaxone using paper analytical devices
17 items

About this collection

A collection of papers and reviews in which sensors have been used to measure analytes in complex matrices, using robust technologies and with high sensitivity and specificity. The scope of this collection covers a broad range of applications (both biomedical and environmental) and includes work which describes challenges in sensing of complex analytes or sensing analytes in complex matrices and how these challenges have been overcome.

The collection is Guest Edited by Charles Mace (Tufts University, USA), Aoife Morrin  (Dublin City University, Ireland) and Rebecca Whelan (University of Notre Dame, USA).


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