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Electrochemical Detection of Bovine Immunoglobulins G to Determine Passive Transfer of Antibodies to Calves

Abstract

Bovine antibodies, such as immunoglobulins G (IgG), cannot pass the placental barrier and as such are not transferred from the mother to the foetus, in utero. Instead a calf must absorb antibodies following ingestion of colostrum postpartum. Failure Passive Transfer (FPT) is a condition that predisposes calves to development of disease and increases the risk of mortality. Thus, continuous early monitoring of IgG absorption in a calf, within the first 6 to 12 hours of life, is imperative to allow faster treatment and prevent FPT. In this paper, we present the development of a label-free impedimetric immunosensor device for bovine IgG in serum and demonstrate its suitability to determine early FPT in new-born calves. The developed sensors were challenged to discriminate between new born calf sera, both pre- and post-colostrum feeding, and demonstrated efficent detection of IgG in under 15 minutes. Such a device could enable rapid determination of FPT, thereby improving calves’ vitality and survival rate.

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Article information


Submitted
30 Jan 2020
Accepted
04 May 2020
First published
15 May 2020

Anal. Methods, 2020, Accepted Manuscript
Article type
Paper

Electrochemical Detection of Bovine Immunoglobulins G to Determine Passive Transfer of Antibodies to Calves

C. Robinson, N. Creedon, R. Sayers, E. Kennedy and A. O'Riordan, Anal. Methods, 2020, Accepted Manuscript , DOI: 10.1039/D0AY00194E

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