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Themed collection 2018 Chemical Science HOT Article Collection

73 items - Showing page 1 of 2
Open Access Edge Article

Oxidative dehalogenation and denitration by a flavin-dependent monooxygenase is controlled by substrate deprotonation

Enzymes that are capable of detoxifying halogenated phenols (HPs) and nitrophenols (NPs) are valuable for bioremediation and waste biorefining.

Graphical abstract: Oxidative dehalogenation and denitration by a flavin-dependent monooxygenase is controlled by substrate deprotonation
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Conformational selectivity and high-affinity binding in the complexation of N-phenyl amides in water by a phenyl extended calix[4]pyrrole

We report the synthesis of a tetrapyridinium phenyl extended calix[4]pyrrole receptor that shows high binding affinity and selectivity for the complexation of the cis-conformers of N-phenyl amides in water.

Graphical abstract: Conformational selectivity and high-affinity binding in the complexation of N-phenyl amides in water by a phenyl extended calix[4]pyrrole
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Combined reversible switching of ECD and quenching of CPL with chiral fluorescent macrocycles

A series of chiral fluorescent macrocycles display a remarkable combination of both +/– ECD and strong on/off CPL reversible switching upon cation binding and displacement.

Graphical abstract: Combined reversible switching of ECD and quenching of CPL with chiral fluorescent macrocycles
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

An ultrasensitive flow cytometric immunoassay based on bead surface-initiated template-free DNA extension

An ultrasensitive flow cytometric immunoassay (TdT-FCI) is developed based on bead surface-initiated template-free DNA extension.

Graphical abstract: An ultrasensitive flow cytometric immunoassay based on bead surface-initiated template-free DNA extension
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Accepted Manuscript - Edge Article

Facile room temperature synthesis of large graphene sheets from simple molecules

From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Accepted Manuscript - Edge Article

Tailor-made Janus lectin with dual avidity assembles glycoconjugate multilayers and crosslinks protocells

From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Accepted Manuscript - Edge Article

Biocatalyst – artificial metalloenzyme cascade based on alcohol dehydrogenase

From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Facile and systematic access to the least-coordinating WCA [(RFO)3Al–F–Al(ORF)3] and its more Lewis-basic brother [F–Al(ORF)3] (RF = C(CF3)3)

The least-coordinating anion [(RFO)3Al–F–Al(ORF)3] and its more Lewis-basic brother [F–Al(ORF)3] (RF = C(CF3)3).

Graphical abstract: Facile and systematic access to the least-coordinating WCA [(RFO)3Al–F–Al(ORF)3]− and its more Lewis-basic brother [F–Al(ORF)3]− (RF = C(CF3)3)
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

ZrMOF nanoparticles as quenchers to conjugate DNA aptamers for target-induced bioimaging and photodynamic therapy

Aptamer conjugated porphyrinic metal–organic framework (MOF) achieved target-induced bioimaging and photodynamic therapy.

Graphical abstract: ZrMOF nanoparticles as quenchers to conjugate DNA aptamers for target-induced bioimaging and photodynamic therapy
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Accepted Manuscript - Edge Article

Synthetic biology approaches and combinatorial biosynthesis towards heterologous lipopeptide production

From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Tuning the reactivity of nitriles using Cu(II) catalysis – potentially prebiotic activation of nucleotides

A synergistic system was established involving activating nucleotides with nitriles using Cu(II) and protecting RNA degradation by byproducts of alpha-aminonitriles.

Graphical abstract: Tuning the reactivity of nitriles using Cu(ii) catalysis – potentially prebiotic activation of nucleotides
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Switchable gate-opening effect in metal–organic polyhedra assemblies through solution processing

Assemblies of lantern-type metal–organic polyhedra are found to show gate-opening gas adsorption depending on how they are treated with solvents.

Graphical abstract: Switchable gate-opening effect in metal–organic polyhedra assemblies through solution processing
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Diastereo- and enantioselective copper catalyzed hydroallylation of disubstituted cyclopropenes

A highly diastereo- and enantioselective protocol for the hydroallylation of 1,1- and 1,2-disubstituted cyclopropenes has been developed utilizing an in situ formed copper hydride.

Graphical abstract: Diastereo- and enantioselective copper catalyzed hydroallylation of disubstituted cyclopropenes
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Exploration of biocompatible AIEgens from natural resources

In this contribution, we propose natural resources as a new source to acquire biocompatible AIEgens.

Graphical abstract: Exploration of biocompatible AIEgens from natural resources
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Hierarchical tandem assembly of planar [3×3] building units into {3×[3×3]} oligomers: mixed-valency, electrical conductivity and magnetism

Electrical conductors are made from flat grid clusters of copper using mixed-valency and supramolecular interactions between the enveloping organic ligands.

Graphical abstract: Hierarchical tandem assembly of planar [3×3] building units into {3×[3×3]} oligomers: mixed-valency, electrical conductivity and magnetism
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Multi-omics and temporal dynamics profiling reveal disruption of central metabolism in Helicobacter pylori on bismuth treatment

Integration of multi-omics analyses uncovers the dynamic responses of H. pylori upon bismuth treatment.

Graphical abstract: Multi-omics and temporal dynamics profiling reveal disruption of central metabolism in Helicobacter pylori on bismuth treatment
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Supercooling of functional alkyl-π molecular liquids

The formation of a metastable supercooled alkyl-π molecular liquid was prohibited by subtle alteration of the molecular structure.

Graphical abstract: Supercooling of functional alkyl-π molecular liquids
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Near-infrared fluorescence probes to detect reactive oxygen species for keloid diagnosis

Development of molecular probes for the detection of reactive oxygen and nitrogen species (RONS) is important for the pathology and diagnosis of keloid diseases.

Graphical abstract: Near-infrared fluorescence probes to detect reactive oxygen species for keloid diagnosis
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Accepted Manuscript - Edge Article

Diastereoselective C–H carbonylative annulation of aliphatic amines: a rapid route to functionalized γ–lactams

From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Treatment of hyperphosphatemia based on specific interactions between phosphorus and Zr(IV) active centers of nano-MOFs

We describe a kind of Zr(IV)-based nano-MOF that is well suited for specific adsorption and selective fluorescence sensing of phosphate based on specific interactions between Zr(IV) and phosphate which provides a new approach for treatment of hyperphosphatemia.

Graphical abstract: Treatment of hyperphosphatemia based on specific interactions between phosphorus and Zr(iv) active centers of nano-MOFs
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Unraveling reaction networks behind the catalytic oxidation of methane with H2O2 over a mixed-metal MIL-53(Al,Fe) MOF catalyst

Reaction paths underlying the catalytic oxidation of methane with H2O2 over an Fe containing MIL-53(Al) metal–organic framework were studied by periodic DFT calculations.

Graphical abstract: Unraveling reaction networks behind the catalytic oxidation of methane with H2O2 over a mixed-metal MIL-53(Al,Fe) MOF catalyst
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Replacing H+ by Na+ or K+ in phosphopeptide anions and cations prevents electron capture dissociation

By successively replacing H+ by Na+ or K+ in phosphopeptide anions and cations, we show that the efficiency of fragmentation into c and z˙ or c˙ and z fragments from N–Cα backbone bond cleavage by negative ion electron capture dissociation (niECD) and electron capture dissociation (ECD) substantially decreases with increasing number of alkali ions attached.

Graphical abstract: Replacing H+ by Na+ or K+ in phosphopeptide anions and cations prevents electron capture dissociation
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Reversible coordination of N2 and H2 to a homoleptic S = 1/2 Fe(I) diphosphine complex in solution and the solid state

A 15 valence-electron Fe(I) species rapidly and reversibly binds N2 and H2, the latter producing a rare paramagnetic dihydrogen complex.

Graphical abstract: Reversible coordination of N2 and H2 to a homoleptic S = 1/2 Fe(i) diphosphine complex in solution and the solid state
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Bright insights into palladium-triggered local chemotherapy

We report fundamental insights into the validity, reliability and clinical feasibility of using heterogeneous Pd catalysts as implantable devices to accurately activate chemotherapy within a tumour.

Graphical abstract: Bright insights into palladium-triggered local chemotherapy
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Dynamically imaging collision electrochemistry of single electrochemiluminescence nano-emitters

Dynamically imaging stochastic collision electrochemistry of single nanoparticles by electrochemiluminescence microscopy enables visualization of diverse collision behaviours.

Graphical abstract: Dynamically imaging collision electrochemistry of single electrochemiluminescence nano-emitters
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Highly luminescent phosphine oxide-containing bipolar alkynylgold(III) complexes for solution-processable organic light-emitting devices with small efficiency roll-offs

Phosphine oxide-containing alkynylgold(III) complexes were synthesized and fabricated into solution-processable OLEDs with high EQEs and small efficiency roll-offs.

Graphical abstract: Highly luminescent phosphine oxide-containing bipolar alkynylgold(iii) complexes for solution-processable organic light-emitting devices with small efficiency roll-offs
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

New enzymatic and mass spectrometric methodology for the selective investigation of gut microbiota-derived metabolites

New sulfatase-based assay for the selective identification of sulfate esters in human urine and fecal samples.

Graphical abstract: New enzymatic and mass spectrometric methodology for the selective investigation of gut microbiota-derived metabolites
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

A sequence-activated AND logic dual-channel fluorescent probe for tracking programmable drug release

A sense-of-logic dual-channel nanoprobe is operated via a sequence-activated AND logic gate by responding ultra-sensitively to pH changes and being subsequently triggered with biothiol for the controllable release of anti-cancer drugs.

Graphical abstract: A sequence-activated AND logic dual-channel fluorescent probe for tracking programmable drug release
From the themed collection: 2018 ChemSci Pick of the Week Collection
Open Access Edge Article

Shaping excitons in light-harvesting proteins through nanoplasmonics

Through multiscale simulations, it is shown that nanoplasmonic tips can selectively localize the excitation in LH2 light-harvesting complex, narrowing down to probing one single pigment.

Graphical abstract: Shaping excitons in light-harvesting proteins through nanoplasmonics
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Concentrated electrolytes stabilize bismuth–potassium batteries

A 5 molar concentrated electrolyte effectively stabilizes bismuth–potassium batteries due to its elevated resistance to electrochemical reduction.

Graphical abstract: Concentrated electrolytes stabilize bismuth–potassium batteries
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

A two-qubit molecular architecture for electron-mediated nuclear quantum simulation

A molecular architecture where two vanadyl-based qubits are linked together is herein described and investigated as a platform for quantum simulation.

Graphical abstract: A two-qubit molecular architecture for electron-mediated nuclear quantum simulation
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Consequences of a cosolvent on the structure and molecular dynamics of supramolecular polymers in water

A cosolvent that is used to guide the self-assembly of amphiphiles in water causes abrupt structural changes, as well as non-linear behavior in the molecular dynamics of the amphiphiles.

Graphical abstract: Consequences of a cosolvent on the structure and molecular dynamics of supramolecular polymers in water
From the themed collection: 2018 ChemSci Pick of the Week Collection
Open Access Edge Article

Large-bite diboranes for the μ(1,2) complexation of hydrazine and cyanide

A diborane based on the 1,8-biphenylenediyl backbone displays a high affinity for hydrazine while also behaving as a cyanide sponge.

Graphical abstract: Large-bite diboranes for the μ(1,2) complexation of hydrazine and cyanide
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor

Using machine learning, targets were identified for β-lapachone.

Graphical abstract: Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Visualization of methylglyoxal in living cells and diabetic mice model with a 1,8-naphthalimide-based two-photon fluorescent probe

A 1,8-naphthalimide-based two-photon fluorescent probe was designed to visualize MGO levels in living cells and a diabetic mice model.

Graphical abstract: Visualization of methylglyoxal in living cells and diabetic mice model with a 1,8-naphthalimide-based two-photon fluorescent probe
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Enhancement of triplet-sensitized upconversion in rigid polymers via singlet exciton sink approach

Quenching of emitter singlets by the sensitizer limits the efficiency of sensitized upconversion, unless an emissive exciton sink is employed.

Graphical abstract: Enhancement of triplet-sensitized upconversion in rigid polymers via singlet exciton sink approach
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Disarming the virulence arsenal of Pseudomonas aeruginosa by blocking two-component system signaling

Pseudomonas aeruginosa infections have reached a “critical” threat status making novel therapeutic approaches required.

Graphical abstract: Disarming the virulence arsenal of Pseudomonas aeruginosa by blocking two-component system signaling
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

A redox-activated theranostic nanoagent: toward multi-mode imaging guided chemo-photothermal therapy

We construct a tumor redox microenvironment responsive core–shell therapeutic nanoagent for multi-mode imaging guided synergistic therapy in vitro and in vivo.

Graphical abstract: A redox-activated theranostic nanoagent: toward multi-mode imaging guided chemo-photothermal therapy
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Synthesis and structural characterization of inverse-coordination clusters from a two-electron superatomic copper nanocluster

Cuboctahedral copper clusters containing a twelve-coordinated main group element (Cl, Br, S) at the center have been synthesized and characterized.

Graphical abstract: Synthesis and structural characterization of inverse-coordination clusters from a two-electron superatomic copper nanocluster
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Interfacing porphyrins and carbon nanotubes through mechanical links

U-shaped bisporphyrin molecules are clipped around SWCNTs using ring-closing metathesis yielding rotaxane-type derivatives, in which porphyrins and SWCNTs are connected through mechanical links.

Graphical abstract: Interfacing porphyrins and carbon nanotubes through mechanical links
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Design of a ratiometric two-photon probe for imaging of hypochlorous acid (HClO) in wounded tissues

A ratiometric two-photon probe was designed to visualize HClO levels in tissues, revealing the generation of HClO in the wound-repairing process of mice for the first time.

Graphical abstract: Design of a ratiometric two-photon probe for imaging of hypochlorous acid (HClO) in wounded tissues
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Highly diastereoselective synthesis of tricyclic fused-pyrans by sequential hydride shift mediated double C(sp3)–H bond functionalization

Highly diastereoselective synthesis of tricyclic fused-pyrans was achieved by Brønsted acid catalyzed double C(sp3)–H bond functionalization.

Graphical abstract: Highly diastereoselective synthesis of tricyclic fused-pyrans by sequential hydride shift mediated double C(sp3)–H bond functionalization
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Selective hydrogenation of 1,3-butadiene catalyzed by a single Pd atom anchored on graphene: the importance of dynamics

The active-site structure, reaction mechanism, and product selectivity of the industrially important selective hydrogenation of 1,3-butadiene are investigated using first principles for an emerging single-atom Pd catalyst anchored on graphene.

Graphical abstract: Selective hydrogenation of 1,3-butadiene catalyzed by a single Pd atom anchored on graphene: the importance of dynamics
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Synthesis of a 2D phosphorus material in a MOF-based 2D nano-reactor

A 2D nano-reactor was constructed within a pillar–layer-MOF, in which a moderately stable 2D phosphorus material was synthesized.

Graphical abstract: Synthesis of a 2D phosphorus material in a MOF-based 2D nano-reactor
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

A multifunctional SERS sticky note for real-time quorum sensing tracing and inactivation of bacterial biofilms

A multifunctional SERS sticky note is designed for real-time tracing of quorum sensing and inhibiting bacterial growth of live biofilms.

Graphical abstract: A multifunctional SERS sticky note for real-time quorum sensing tracing and inactivation of bacterial biofilms
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Fine-tuned organic photoredox catalysts for fragmentation-alkynylation cascades of cyclic oxime ethers

Fine-tuned organic photoredox catalysts are introduced for the metal-free alkynylation of alkylnitrile radicals generated via oxidative ring opening of cyclic alkylketone oxime ethers.

Graphical abstract: Fine-tuned organic photoredox catalysts for fragmentation-alkynylation cascades of cyclic oxime ethers
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Let there be light: stability of palmitic acid monolayers at the air/salt water interface in the presence and absence of simulated solar light and a photosensitizer

The stability of palmitic acid monolayers at the air/salt water interface changes in the presence of light and a photosensitizer.

Graphical abstract: Let there be light: stability of palmitic acid monolayers at the air/salt water interface in the presence and absence of simulated solar light and a photosensitizer
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Deciphering the mechanism of O2 reduction with electronically tunable non-heme iron enzyme model complexes

A homologous series of electronically tuned ligands were prepared and some of their corresponding Fe complexes were prepared and a Hammett plot of the rates of O2 reduction allowed us to infer important details of the mechanism.

Graphical abstract: Deciphering the mechanism of O2 reduction with electronically tunable non-heme iron enzyme model complexes
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Chiral Brønsted acid-catalyzed intramolecular SN2′ reaction for enantioselective construction of a quaternary stereogenic center

Construction of a quaternary stereogenic center was accomplished through the enantioselective intramolecular allylic substitution reaction of bis-trichloroacetimidate catalyzed by a chiral phosphoramide derivative.

Graphical abstract: Chiral Brønsted acid-catalyzed intramolecular SN2′ reaction for enantioselective construction of a quaternary stereogenic center
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

White-light emission from a single organic compound with unique self-folded conformation and multistimuli responsiveness

White-light emission from a single molecule was realized and tuned via multistimuli including excitation, solvent polarity, temperature and host–guest interactions.

Graphical abstract: White-light emission from a single organic compound with unique self-folded conformation and multistimuli responsiveness
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Revitalizing the concept of bond order through delocalization measures in real space

Quantum mechanical bond orders are obtained from integration of the exchange–correlation density between topological atoms.

Graphical abstract: Revitalizing the concept of bond order through delocalization measures in real space
From the themed collection: 2018 ChemSci Pick of the Week Collection
Open Access Edge Article

Direct heterobenzylic fluorination, difluorination and trifluoromethylthiolation with dibenzenesulfonamide derivatives

Transient sulfonylation of azaheterocycles by N-fluoro or N-trifluoromethylthio dibenzenesulfonimide enables heterobenzylic fluorination, difluorination and trifluoromethylthiolation.

Graphical abstract: Direct heterobenzylic fluorination, difluorination and trifluoromethylthiolation with dibenzenesulfonamide derivatives
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Revealing the unusual role of bases in activation/deactivation of catalytic systems: O–NHC coupling in M/NHC catalysis

Usual oxygen bases decompose M/NHC complexes to give “NHC-free” metal species and azolones.

Graphical abstract: Revealing the unusual role of bases in activation/deactivation of catalytic systems: O–NHC coupling in M/NHC catalysis
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Probing the interaction between the encapsulated water molecule and the fullerene cages in H2O@C60 and H2O@C59N

The guest–host interactions in the H2O@C60 and H2O@C59N endohedral fullerenes are probed by high-resolution photoelectron imaging.

Graphical abstract: Probing the interaction between the encapsulated water molecule and the fullerene cages in H2O@C60− and H2O@C59N−
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Rapid photoinduced charge injection into covalent polyoxometalate–bodipy conjugates

A series of redox tunable polyoxometalate–bodipy conjugates display variable charge transfer dynamics occuring down to 54 ps.

Graphical abstract: Rapid photoinduced charge injection into covalent polyoxometalate–bodipy conjugates
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Site-selective C–C modification of proteins at neutral pH using organocatalyst-mediated cross aldol ligations

An organocatalyst-mediated protein aldol ligation (OPAL) affords C–C linked bioconjugates at neutral pH.

Graphical abstract: Site-selective C–C modification of proteins at neutral pH using organocatalyst-mediated cross aldol ligations
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Diffusion across a gel–gel interface – molecular-scale mobility of self-assembled ‘solid-like’ gel nanofibres in multi-component supramolecular organogels

The diffusion of vital components of gel nanofibres across a gel–gel interface is quantified – highly dynamic, self-assembled, two-component gels can adapt and reorganise over time.

Graphical abstract: Diffusion across a gel–gel interface – molecular-scale mobility of self-assembled ‘solid-like’ gel nanofibres in multi-component supramolecular organogels
From the themed collection: 2018 ChemSci Pick of the Week Collection
Open Access Edge Article

A fluorescent τ-probe: quantitative imaging of ultra-trace endogenous hydrogen polysulfide in cells and in vivo

A fluorescent τ-probe was demonstrated to quantitate ultra-trace endogenous hydrogen sulfide (H2Sn) within cells and zebrafish through changes of fluorescence lifetime.

Graphical abstract: A fluorescent τ-probe: quantitative imaging of ultra-trace endogenous hydrogen polysulfide in cells and in vivo
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Total chemical synthesis and biophysical properties of a designed soluble 24 kDa amyloid analogue

A soluble amyloid analogue was designed and prepared by total chemical synthesis using native chemical ligation.

Graphical abstract: Total chemical synthesis and biophysical properties of a designed soluble 24 kDa amyloid analogue
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Genetically encoded tags for real time dissection of protein assembly in living cells

Genetically encoded tags (MoTags) to assess protein oligomeric states, probe protein structure and monitor protein–target interactions under physiological conditions in cellulo.

Graphical abstract: Genetically encoded tags for real time dissection of protein assembly in living cells
From the themed collection: 2018 ChemSci Pick of the Week Collection
Open Access Edge Article

Thermodynamic versus kinetic control in substituent redistribution reactions of silylium ions steered by the counteranion

Substituent exchange reactions of silylium ions can be steered in opposite directions. The judicious choice of the hydrosilane and the counteranion enables the selective formation of either triaryl- or trialkylsilylium ions.

Graphical abstract: Thermodynamic versus kinetic control in substituent redistribution reactions of silylium ions steered by the counteranion
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Tunable syngas production from photocatalytic CO2 reduction with mitigated charge recombination driven by spatially separated cocatalysts

This paper describes the production of syngas from photocatalytic CO2 reduction with a tunable CO/H2 ratio via adjusting the properties of CuPt alloy and the distribution of cocatalysts on TiO2 hollow spheres.

Graphical abstract: Tunable syngas production from photocatalytic CO2 reduction with mitigated charge recombination driven by spatially separated cocatalysts
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Rechargeable aluminum–selenium batteries with high capacity

An aluminum–selenium battery powered by the reversible redox reaction of Se/Se2Cl2 has been developed for the first time.

Graphical abstract: Rechargeable aluminum–selenium batteries with high capacity
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Pyrene hydrogel for promoting direct bioelectrochemistry: ATP-independent electroenzymatic reduction of N2

We demonstrate a novel hydrogel material to facilitate direct bioelectrochemistry of a wide range of redox proteins and enable ATP-independent electroenzymatic reduction of N2 by nitrogenase.

Graphical abstract: Pyrene hydrogel for promoting direct bioelectrochemistry: ATP-independent electroenzymatic reduction of N2
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

A high spatiotemporal study of somatic exocytosis with scanning electrochemical microscopy and nanoITIES electrodes

Extra-synaptic exocytosis is an essential component of cellular communication. A knowledge gap exists in the exocytosis of the non-redox active transmitter acetylcholine. Using the nano-interface between two immiscible electrolyte solutions and scanning electrochemical microscopy, a high resolution spatiotemporal study of acetylcholine exocytosis is shown from individual neuronal soma.

Graphical abstract: A high spatiotemporal study of somatic exocytosis with scanning electrochemical microscopy and nanoITIES electrodes
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Enantioselective radical process for synthesis of chiral indolines by metalloradical alkylation of diverse C(sp3)–H bonds

A new C–C bond formation strategy based on enantioselective radical alkylation of C(sp3)–H bonds via Co(II)-based metalloradical catalysis has been demonstrated for stereoselective synthesis of chiral indolines.

Graphical abstract: Enantioselective radical process for synthesis of chiral indolines by metalloradical alkylation of diverse C(sp3)–H bonds
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Protein surface functionalisation as a general strategy for facilitating biomimetic mineralisation of ZIF-8

The surface charge and chemistry of a protein determines its ability to facilitate biomimetic mineralisation.

Graphical abstract: Protein surface functionalisation as a general strategy for facilitating biomimetic mineralisation of ZIF-8
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Identification of Pt-based catalysts for propane dehydrogenation via a probability analysis

A probability-based computational screening study has successfully identified an optimal bimetallic alloy (Pt3In) for the propane dehydrogenation reaction.

Graphical abstract: Identification of Pt-based catalysts for propane dehydrogenation via a probability analysis
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Sequential electron transfer governs the UV-induced self-repair of DNA photolesions

QM/MM simulations elucidate the self-repair mechanism of the cyclobutane pyrimidine dimer.

Graphical abstract: Sequential electron transfer governs the UV-induced self-repair of DNA photolesions
From the themed collection: 2018 Chemical Science HOT Article Collection
Open Access Edge Article

Label-free and live cell imaging by interferometric scattering microscopy

Despite recent remarkable advances in microscopic techniques, it still remains very challenging to directly observe the complex structure of cytoplasmic organelles in live cells without a fluorescent label.

Graphical abstract: Label-free and live cell imaging by interferometric scattering microscopy
From the themed collection: 2018 Chemical Science HOT Article Collection
73 items - Showing page 1 of 2

About this collection

This on-going web collection showcases all of the HOT Chemical Science articles published in 2018, as recommended by referees. Congratulations to all of the authors whose articles are featured.

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