Themed collection Recent analytical chemistry science from China

Novelty: Recent advances in real-time and in situ monitoring of an electrode–electrolyte interface by mass spectrometry are reviewed.

In this mini review, we will provide a brief introduction focusing on the current applications of single plasmonic nanoparticle-based sensors using DFM, including the detection of molecules, the real-time monitoring of chemical/electrochemical reactions and the imaging of living cells.

Intracellular pH values are some of the most important factors that govern biological processes and the acid–base homeostasis in cells, body fluids and organs sustains the normal operations of the body.

Cells are the most basic structural units that play vital roles in the functioning of living organisms.

Molecularly imprinted polymers (MIPs) are produced using molecular imprinting technology (MIT) and have specific analyte-binding abilities and unique properties, including chemical and thermal stability, reusability, high selectivity, and high sensitivity.

Electrochemiluminescence (ECL) has attracted much attention in various fields of analysis owing to low background signals, high sensitivity, and excellent controllability.

Herein, we review and summarise the development and biological applications of DNA tetrahedron, including cellular biosensors and drug delivery systems.

A novel ratiometric fluorescence assay for cerebral Cu²⁺ has been developed based on coumarin-labeled single-stranded DNA coupled with the Cu²⁺-induced oxidation of o-phenylenediamine.

A novel method of noninvasive photoacoustic glucose measurement utilizing the amplitude and phase difference information.

A multiple signal amplification of a SERS biosensor was developed for sensitive detection of cTnI with the aid of GO/AuNP complexes.

A simple far-red fluorescent probe was developed to monitor mercury ions in environmental water samples and in living systems.

A simple and novel strategy for detection of AA and ALP via controlled generation of Ag NPs and selective recognition.

Electrosyringe-assisted electrospray mass spectrometry (MS) is established for the first time to achieve intracellular sampling from one axon or dendrite in living neurons for mass spectrometric analysis.

Herein, we employ pH-dependent solubility equilibrium to develop the one-pot aqueous synthesis of dual-color emission fluorescent carbon nanosphere (DFCSs) with novel physicochemical properties.

A portable electrochemical immunosensor was designed for the detection of CEA on a pH meter by using glucose oxidase-encapsulated gold hollow microspheres for signal amplification.

A novel dual-emission fluorescent nanocomposite material, CDs/Cu NCs, was fabricated for detecting trace water in organic solvents (DMSO, DMF, THF, and ACN).

A PTCA-RGO-MWCNT-Au NP nanocomposite was facilely fabricated for highly sensitive and selective electrochemical detection of dopamine.

Based on a “signal-on” sensing strategy and a three-stage cascade signal amplification method, an ultrasensitive photoelectrochemical biosensor has been developed for DNA detection.

A multi-faceted site-specific quantitative N-glycoproteomics workflow was developed to probe PKM2 signaling.

Aptamers selectively binding to glioblastoma multiforme cells were identified.

Glycosylation is a crucial process in protein biosynthesis.

Ternary nanocomposites of Au/CuS/TiO₂ hybrid arrays were prepared for the fabrication of an ultrasensitive photoelectrochemical non-enzymatic glucose sensor.

Hydrogen sulfide (H₂S) and biothiol molecules, such as glutathione (GSH), cysteine (Cys), and homocysteine (Hcy), play an important role in biology.

A reversible fluorescent probe for the selective imaging of formaldehyde in living cells, tissues and in vivo.

MoS₂/Pt nanocomposites functionalized acupuncture needle for real-time monitoring of H₂O₂ release from living cells.

For the successful treatment of infections, real-time analysis and enhanced multiplex capacity, sensitivity and cost-effectiveness of the developed detection method are critical.

A novel colorimetric immunoassay is designed for the ultrasensitive detection of the human prostate-specific antigen (PSA) by using a unique type of nanolabel – high-index {hk0} faceted platinum concave nanocubes.

A 3D N-doped hierarchically porous carbon modified electrode enables simultaneous sensitive detection of ascorbic acid, dopamine and uric acid.

We developed a nitroreductase responsive theranostic probe 1; it comprises biotinylated rhodol in conjunction with p-nitrobenzyl functionality.