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Issue 18, 2017
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Ratiometric fluorescence monitoring of cerebral Cu2+ based on coumarin-labeled DNA coupled with the Cu2+-induced oxidation of o-phenylenediamine

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Abstract

A novel and facile ratiometric fluorescence method for evaluating Cu2+ has been developed based on coumarin-labeled single-stranded DNA (C-ssDNA) coupled with the Cu2+-induced oxidation of o-phenylenediamine (OPD). By combining the microdialysis technique, the ratiometric fluorescence method has also been successfully exploited to monitor the cerebral Cu2+ in the rat brain, promising new opportunities for studying the cerebral Cu2+-associated physiological and pathological events.

Graphical abstract: Ratiometric fluorescence monitoring of cerebral Cu2+ based on coumarin-labeled DNA coupled with the Cu2+-induced oxidation of o-phenylenediamine

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Publication details

The article was received on 01 Jul 2017, accepted on 02 Aug 2017 and first published on 04 Aug 2017


Article type: Communication
DOI: 10.1039/C7AN01099K
Citation: Analyst, 2017,142, 3341-3345
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    Ratiometric fluorescence monitoring of cerebral Cu2+ based on coumarin-labeled DNA coupled with the Cu2+-induced oxidation of o-phenylenediamine

    S. Ma, Q. Zhou, F. Mu, Z. Chen, X. Ding, M. Zhang and G. Shi, Analyst, 2017, 142, 3341
    DOI: 10.1039/C7AN01099K

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