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Ratiometric fluorescent monitoring of cerebral Cu2+ based on coumarin-labeled DNA coupled with Cu2+-induced oxidation of o-phenylenediamine

Abstract

A novel and facile ratiometric fluorescent method for evaluating Cu2+ has been developed based on coumarin-labeled single-strand DNA (C-ssDNA) coupled with Cu2+-induced oxidation of o-phenylenediamine (OPD). By combining the microdialysis technique, the ratiometric fluorescent method has also been successfully exploited to monitor the cerebral Cu2+ in rat brain, promising new opportunities for studying the cerebral Cu2+-involved physiological and pathological events.

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Publication details

The article was received on 01 Jul 2017, accepted on 02 Aug 2017 and first published on 04 Aug 2017


Article type: Communication
DOI: 10.1039/C7AN01099K
Citation: Analyst, 2017, Accepted Manuscript
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    Ratiometric fluorescent monitoring of cerebral Cu2+ based on coumarin-labeled DNA coupled with Cu2+-induced oxidation of o-phenylenediamine

    S. Ma, Q. Zhou, F. Mu, Z. Chen, X. Ding, M. Zhang and G. Shi, Analyst, 2017, Accepted Manuscript , DOI: 10.1039/C7AN01099K

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