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DNA Tetrahedron Nanostructures for Biological Applications: Biosensors and Drug Delivery


With the rapid development of DNA nanotechnology, various DNA nanostructures with different shapes and sizes have been self-assembled using “bottom-up” fabrication strategies, and applied in a wide range of fields, such as biosensors, drug delivery and tools for molecular biology. As a classical and simplest polyhedron, DNA tetrahedron can be easily synthesised by one-step assembly. Due to the excellent biocompatibility and cellular permeability, it provides a universal and promising platform to construct a series of biosensors and drug delivery systems for living cells studies. Moreover, the high programmability of DNA tetrahedron determines its capability to perform artful design and combine with other materials. Here, we review and summarise the development and applications of DNA tetrahedron in living cell studies. We mainly focus on two parts, including cellular biosensors for the detection of nucleic acids, proteins, small molecules and cancer cells, and drug delivery systems for chemotherapy, immunotherapy, photodynamic therapy and gene silencing. With the rapid progress in DNA tetrahedron as well as DNA nanotechnology, it opens up new avenues and opportunities in analytical chemistry, molecular biology and medicine.

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Publication details

The article was received on 09 Jul 2017, accepted on 01 Aug 2017 and first published on 07 Aug 2017

Article type: Critical Review
DOI: 10.1039/C7AN01154G
Citation: Analyst, 2017, Accepted Manuscript
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    DNA Tetrahedron Nanostructures for Biological Applications: Biosensors and Drug Delivery

    N. Xie, S. Liu, X. Yang, X. He, J. Huang and K. Wang, Analyst, 2017, Accepted Manuscript , DOI: 10.1039/C7AN01154G

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