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MoS2/ Pt nanocomposites functionalized microneedle for real-time monitoring of hydrogen peroxide release from living cell

Abstract

This work describes the adaptive use of conventional stainless steel acupuncture needle as the electrode substrate for construction of molybdenum disulfide (MoS2) and platinum nanoparticles (PtNPs) layer modified microneedle sensor for real-time monitoring of hydrogen peroxide (H2O2) release from living cell. To construct the nanocomposite-functionalized microneedle, the needle surface was first coated with a gold film by ion sputtering to enhance the conductivity. Subsequently, an electrochemical deposition method was successfully employed to deposit MoS2 nanosheet and Pt nanoparticles on the needle tip as the sensing interface, respectively. Electrochemical study demonstrated that the MoS2/PtNPs nanocomposites modified needle exhibited an excellent catalytic performance and low over-potential toward the reduction of H2O2. Not only did the microneedle achieve a wide linear range from 1 to 100 μmol/L with limit of detection down to 0.686 μmol/L, but also it realized the highly specific detection of H2O2. Due to these remarkable analytical advantages, the prepared microneedle was applied to determine H2O2 release from living cells with satisfactory results. The MoS2/PtNPs nanocomposites functionalized microneedle sensor is simple and affordable, and can be serving as a promising electrochemical nonenzymatic sensing platform. Moreover, this superfine needle sensor shows a great potential for real-time monitoring of reactive oxygen species in vivo with the least damage.

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Publication details

The article was received on 01 Sep 2017, accepted on 12 Oct 2017 and first published on 13 Oct 2017


Article type: Paper
DOI: 10.1039/C7AN01446E
Citation: Analyst, 2017, Accepted Manuscript
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    MoS2/ Pt nanocomposites functionalized microneedle for real-time monitoring of hydrogen peroxide release from living cell

    J. Zhou, L. Tang, F. Yang, F. Liang, H. Wang, Y. Li and G. Zhang, Analyst, 2017, Accepted Manuscript , DOI: 10.1039/C7AN01446E

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