Themed collection Global challenges: Health & Food
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Sulfonyl fluorides as privileged warheads in chemical biology
The use of sulfonyl fluoride probes in chemical biology is reviewed.
Chem. Sci., 2015,6, 2650-2659
https://doi.org/10.1039/C5SC00408J
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Combination of Ru(II) complexes and light: new frontiers in cancer therapy
In this perspective article, we present the recent achievements in the application of ruthenium complexes as photosensitizers and as photoactivatable prodrugs.
Chem. Sci., 2015,6, 2660-2686
https://doi.org/10.1039/C4SC03759F
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Macrocycles: lessons from the distant past, recent developments, and future directions
A noticeable increase in molecular complexity of drug targets has created an unmet need in the therapeutic agents that are larger than traditional small molecules.
Chem. Sci., 2015,6, 30-49
https://doi.org/10.1039/C4SC03089C
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Construction of homogeneous antibody–drug conjugates using site-selective protein chemistry
The use of site-selective chemical drug-conjugation strategies enables the construction of antibody–drug conjugates (ADCs) with superior therapeutic efficacy.”
Chem. Sci., 2016,7, 2954-2963
https://doi.org/10.1039/C6SC00170J
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Asymmetric 18F-fluorination for applications in positron emission tomography
To date, both transition metal complexes and organomediators have been employed for enantiocontrolled 18F-incorporation as an alternative to conventional resolution of SN2-based radiochemistry.
Chem. Sci., 2016,7, 1645-1652
https://doi.org/10.1039/C5SC04229A
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Palladium: a future key player in the nanomedical field?
Palladium nanostructures with therapeutic potential are emerging as innovative tools in the nanomedical field.
Chem. Sci., 2015,6, 2153-2157
https://doi.org/10.1039/C5SC00070J
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In vitro upconverting/downshifting luminescent detection of tumor markers based on Eu3+-activated core–shell–shell lanthanide nanoprobes
We demonstrate the successful use of Eu3+-activated core–shell–shell nanoprobes for in vitro upconverting/downshifting luminescent detection of a cancer biomarker of alpha-fetoprotein.
Chem. Sci., 2016,7, 5013-5019
https://doi.org/10.1039/C6SC01195K
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The virulence factor LecB varies in clinical isolates: consequences for ligand binding and drug discovery
The sequence of the virulence factor LecB differs significantly between the evolutionarily diverged PAO1- or PA14-like strains and can serve as marker for strain classification. Despite these variations, its comparable ligand selectivity makes LecB a highly promising target for anti-virulence therapy.
Chem. Sci., 2016,7, 4990-5001
https://doi.org/10.1039/C6SC00696E
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Comprehensive multiphase NMR applied to a living organism
Comprehensive Multiphase NMR provides an overview as to all components (liquids, gels, solids) in a living organism.
Chem. Sci., 2016,7, 4856-4866
https://doi.org/10.1039/C6SC00329J
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Targeted multimodal theranostics via biorecognition controlled aggregation of metallic nanoparticle composites
We show that two distinct mechanisms, FRET and MEF, of metallic nanoparticles can be finely tuned by a ligand–receptor interaction, producing a nanocomposite with an enhanced ROS production for targeted imaging and multimodal therapy.
Chem. Sci., 2016,7, 4004-4008
https://doi.org/10.1039/C6SC01463A
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A quadrupolar two-photon fluorescent probe for in vivo imaging of amyloid-β plaques
A quadrupolar two-photon fluorescent probe for in vivo imaging of amyloid-β plaques is reported.
Chem. Sci., 2016,7, 4600-4606
https://doi.org/10.1039/C6SC00355A
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Cationic pillar[6]arene/ATP host–guest recognition: selectivity, inhibition of ATP hydrolysis, and application in multidrug resistance treatment
The efficacy of DOX·HCl against drug resistant human breast cancer cells is enhanced in the presence of a water-soluble pillar[6]arene (WP6) due to the inhibition of ATP hydrolysis upon formation of WP6⊃ATP in cells, providing a novel strategy to overcome multidrug resistance.
Chem. Sci., 2016,7, 4073-4078
https://doi.org/10.1039/C6SC00531D
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Rapid biocompatible macrocyclization of peptides with decafluoro-diphenylsulfone
In this manuscript, we describe modification of Cys-residues in peptides and proteins in aqueous solvents via aromatic nucleophilic substitution (SNAr) with perfluoroarenes (fAr).
Chem. Sci., 2016,7, 3785-3790
https://doi.org/10.1039/C5SC03856A
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Design of potent and highly selective inhibitors for human β-secretase 2 (memapsin 1), a target for type 2 diabetes
Structure-based design and syntheses of potent and highly selective BACE2 inhibitors are described.
Chem. Sci., 2016,7, 3117-3122
https://doi.org/10.1039/C5SC03718B
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Improvement of enzyme-linked immunosorbent assay for the multicolor detection of biomarkers
An activatable graphene-based nanoprobe is used to develop a multicolor immunosorbent assay for the detection of tumor protein biomarkers.
Chem. Sci., 2016,7, 3011-3016
https://doi.org/10.1039/C5SC04256A
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A pillar[5]arene-based [2]rotaxane lights up mitochondria
Here we integrate diagnostic and therapeutic agents into a mitochondria-targeting [2]rotaxane, which can be utilized as a drug delivery platform to conjugate anticancer drugs to prepare prodrugs for efficient targeted drug delivery.
Chem. Sci., 2016,7, 3017-3024
https://doi.org/10.1039/C6SC00036C
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Whipped oil stabilised by surfactant crystals
We describe a protocol for preparing very stable air-in-oil foams containing surfactant crystals starting from a one-phase solution of a fatty acid in a vegetable oil. On cooling, plate-like crystals form which adsorb at air bubble surfaces after aeration of the mixture. Such foams can be destabilised by gradual warming leading to crystal melting and bubble coalescence.
Chem. Sci., 2016,7, 2621-2632
https://doi.org/10.1039/C6SC00046K
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Conjugating a groove-binding motif to an Ir(III) complex for the enhancement of G-quadruplex probe behavior
G-quadruplex groove binder benzo[d,e]isoquinoline was linked to a Ir(III) complex to generate a highly selective DNA probe.
Chem. Sci., 2016,7, 2516-2523
https://doi.org/10.1039/C6SC00001K
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Chemistry informer libraries: a chemoinformatics enabled approach to evaluate and advance synthetic methods
We report a standardized complex molecule diagnostic approach using collections of relevant drug-like molecules which we call chemistry informer libraries.
Chem. Sci., 2016,7, 2604-2613
https://doi.org/10.1039/C5SC04751J
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Structurally plastic peptide capsules for synthetic antimicrobial viruses
A conceptual design for artificial antimicrobial viruses is described.
Chem. Sci., 2016,7, 1707-1711
https://doi.org/10.1039/C5SC03260A
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A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells
A probe for the in situ monitoring of singlet oxygen generation during targeted theranostic photodynamic therapy is developed based on a photosensitizer with aggregation-induced emission (AIE) characteristics and conjugated to a fluorogenic rhodol dye via a singlet oxygen cleavable linker.
Chem. Sci., 2016,7, 1862-1866
https://doi.org/10.1039/C5SC03583J
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A novel quenched fluorescent activity-based probe reveals caspase-3 activity in the endoplasmic reticulum during apoptosis
A selective quenched activity-based probe detects caspase-3 activity in the endoplasmic reticulum of cancerous cells during apoptosis.
Chem. Sci., 2016,7, 1322-1337
https://doi.org/10.1039/C5SC03207E
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Co-delivery of nitric oxide and antibiotic using polymeric nanoparticles
The rise of hospital-acquired infections, also known as nosocomial infections, is a growing concern in intensive healthcare, causing the death of hundreds of thousands of patients and costing billions of dollars worldwide every year.
Chem. Sci., 2016,7, 1016-1027
https://doi.org/10.1039/C5SC02769A
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Targeting antioxidant pathways with ferrocenylated N-heterocyclic carbene supported gold(I) complexes in A549 lung cancer cells
Ferrocenylated-Au(I) carbenes were designed, synthesized, and studied for their ability to generate reactive oxygen species and target antioxidant pathways via multiple mechanisms.
Chem. Sci., 2016,7, 1245-1256
https://doi.org/10.1039/C5SC03519H
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Profiling the reactivity of cyclic C-nucleophiles towards electrophilic sulfur in cysteine sulfenic acid
Oxidation of a protein cysteine thiol to sulfenic acid, termed S-sulfenylation, is a reversible post-translational modification that plays a crucial role in regulating protein function and is correlated with disease states.
Chem. Sci., 2016,7, 400-415
https://doi.org/10.1039/C5SC02569A
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Accurate calculation of the absolute free energy of binding for drug molecules
Free energy calculations based on molecular dynamics and thermodynamic cycles accurately reproduce experimental affinities of diverse bromodomain inhibitors.
Chem. Sci., 2016,7, 207-218
https://doi.org/10.1039/C5SC02678D
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A fully synthetic self-adjuvanting globo H-Based vaccine elicited strong T cell-mediated antitumor immunity
Fully synthetic, self-adjuvanting monophosphoryl lipid A–globo H conjugate elicited strong T cell-mediated immunity that could target and kill breast cancer.
Chem. Sci., 2015,6, 7112-7121
https://doi.org/10.1039/C5SC01402F
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Design, preparation, and selection of DNA-encoded dynamic libraries
DNA-encoded dynamic libraries (DEDLs) are realized by dynamic DNA hybridization and a novel equilibrium-locking mechanism.
Chem. Sci., 2015,6, 7097-7104
https://doi.org/10.1039/C5SC02467F
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Target-fueled DNA walker for highly selective miRNA detection
We report a DNA walking biosensor that can realize the detection of let-7a with a detection limit of 58 fM and high selectivity for resolving one nucleotide variation.
Chem. Sci., 2015,6, 6777-6782
https://doi.org/10.1039/C5SC02784E
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Lab on a single microbead: an ultrasensitive detection strategy enabling microRNA analysis at the single-molecule level
A single microbead-based sensing platform has been developed, which enables the detection of microRNA at the single-molecule level.
Chem. Sci., 2015,6, 6213-6218
https://doi.org/10.1039/C5SC02641E
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Photoelectrochemical device based on Mo-doped BiVO4 enables smart analysis of the global antioxidant capacity in food
An ultrasensitive Mo-doped BiVO4 composite was used to engineer a photoelectrochemical platform for the direct analysis of the global antioxidant capacity. Using this principle, an integrated device was successfully exploited for the “smart” monitoring of antioxidant-rich foodstuffs.
Chem. Sci., 2015,6, 6632-6638
https://doi.org/10.1039/C5SC02277K
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A cell-penetrating protein designed for bimodal fluorescence and magnetic resonance imaging
A protein-based fluorescence and magnetic resonance bimodal imaging probe was explored in vitro, in cells and in mice.
Chem. Sci., 2015,6, 6607-6613
https://doi.org/10.1039/C5SC01925G
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Photoresponsive immunomagnetic nanocarrier for capture and release of rare circulating tumor cells
7-Aminocoumarin compound was synthesized and used as phototrigger to cage EpCAM-antibody to construct a photocontrolled CTCs capture and release system.
Chem. Sci., 2015,6, 6432-6438
https://doi.org/10.1039/C5SC01380A
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Fluorescent carbon dot–molecular salt hydrogels
We report the incorporation of functionalised carbon nanodots within a low molecular weight salt hydrogel enhancing the gelation and fluorescence properties of both the gel and carbon nanomaterial.
Chem. Sci., 2015,6, 6139-6146
https://doi.org/10.1039/C5SC01859E
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The medicinal thiosulfinates from garlic and Petiveria are not radical-trapping antioxidants in liposomes and cells, but lipophilic analogs are
The radical-trapping antioxidant (RTA) activities of allicin and petivericin, thiosulfinates widely believed responsible for the medicinal properties of garlic and Petiveria, were determined in phosphatidylcholine lipid bilayers and mammalian cell culture.
Chem. Sci., 2015,6, 6165-6178
https://doi.org/10.1039/C5SC02270C
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Cell paintballing using optically targeted coacervate microdroplets
A dynamic holographic assembler was used to “paintball” stem cells with coacervate microdroplets loaded with protein, oligonucleotide or molecular dye.
Chem. Sci., 2015,6, 6106-6111
https://doi.org/10.1039/C5SC02266E
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An iridium(III)-based irreversible protein–protein interaction inhibitor of BRD4 as a potent anticancer agent
This is the first report of a metal complex that targets the BRD4-acylated histone protein-protein interaction (PPI).
Chem. Sci., 2015,6, 5400-5408
https://doi.org/10.1039/C5SC02321A
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Cyclometalated iridium(III) complexes as lysosome-targeted photodynamic anticancer and real-time tracking agents
We report the rational design and photodynamic anticancer mechanism studies of iridium(III) complexes with pH-responsive singlet oxygen (1O2) production and lysosome-specific imaging properties.
Chem. Sci., 2015,6, 5409-5418
https://doi.org/10.1039/C5SC01955A
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A supramolecular nanovehicle toward systematic, targeted cancer and tumor therapy
A supramolecular nanovehicle (denoted as SNV) was fabricated by encapsulating zinc phthalocyanine (ZnPc) and doxorubicin (DOX) into a copolymer (PVP-b-PAA-g-FA), so as to achieve systematic and targeted tumor imaging and therapy.
Chem. Sci., 2015,6, 5511-5518
https://doi.org/10.1039/C5SC00994D
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Heterometallic titanium–gold complexes inhibit renal cancer cells in vitro and in vivo
Heterometallic compounds as anticancer agents demonstrating in vivo potential for the first time. Titanocene–gold derivatives: promising candidates for renal cancer.
Chem. Sci., 2015,6, 5269-5283
https://doi.org/10.1039/C5SC01753J
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An inhibitor of ubiquitin conjugation and aggresome formation
An inhibitor of ubiquitin activating E1 enzyme inhibits ubiquitin conjugation and aggresome formation.
Chem. Sci., 2015,6, 5235-5245
https://doi.org/10.1039/C5SC01351H
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Selective glycoprotein detection through covalent templating and allosteric click-imprinting
A hierarchical bottom-up route exploiting reversible covalent interactions with boronic acids and so-called click chemistry for selective glycoprotein detection is described. The self-assembled and imprinted surfaces confer high binding affinities, nanomolar sensitivity, exceptional glycoprotein specificity and selectivity.
Chem. Sci., 2015,6, 5114-5119
https://doi.org/10.1039/C5SC02031J
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HOCl can appear in the mitochondria of macrophages during bacterial infection as revealed by a sensitive mitochondrial-targeting fluorescent probe
HOCl can appear in the mitochondria of macrophages during bacterial infection as revealed by a new sensitive mitochondrial-targeting fluorescent probe.
Chem. Sci., 2015,6, 4884-4888
https://doi.org/10.1039/C5SC01562F
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Targeting virulence: salmochelin modification tunes the antibacterial activity spectrum of β-lactams for pathogen-selective killing of Escherichia coli
New antibiotics are required to treat bacterial infections and counteract the emergence of antibiotic resistance.
Chem. Sci., 2015,6, 4458-4471
https://doi.org/10.1039/C5SC00962F
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Convergent chemo-enzymatic synthesis of mannosylated glycopeptides; targeting of putative vaccine candidates to antigen presenting cells
Convergent chemo-enzymatic synthesis of mannosylated glycopeptides enhances uptake by human antigen presenting cells whilst preserving the immunogenicity of peptide epitopes.
Chem. Sci., 2015,6, 4636-4642
https://doi.org/10.1039/C5SC00952A
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Image-guided combination chemotherapy and photodynamic therapy using a mitochondria-targeted molecular probe with aggregation-induced emission characteristics
Mitochondria-targeted AIE photosensitizers show multifunctions of targeted and image-guided combination chemotherapy and photodynamic therapy.
Chem. Sci., 2015,6, 4580-4586
https://doi.org/10.1039/C5SC00826C
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Luminescence switch-on detection of protein tyrosine kinase-7 using a G-quadruplex-selective probe
A novel luminescent G-quadruplex-selective iridium(III) complex was employed in a G-quadruplex-based detection assay for PTK7.
Chem. Sci., 2015,6, 4284-4290
https://doi.org/10.1039/C5SC01320H
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pH-responsive and switchable triplex-based DNA hydrogels
pH-responsive DNA hydrogels based on Hoogsteen CG·C+ or TA·T triplex structures undergo reversible pH-induced hydrogel/solution transitions.
Chem. Sci., 2015,6, 4190-4195
https://doi.org/10.1039/C5SC00594A
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Supramolecularly engineered phospholipids constructed by nucleobase molecular recognition: upgraded generation of phospholipids for drug delivery
Supramolecularly engineered phospholipids and liposomes based on complementary hydrogen bonding of nucleosides have been developed.
Chem. Sci., 2015,6, 3775-3787
https://doi.org/10.1039/C5SC01188D
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Multiplexed detection of serological cancer markers with plasmon-enhanced Raman spectro-immunoassay
A plasmon-enhanced Raman spectroscopic assay has been developed for multiplexed detection of breast cancer markers—with high sensitivity and exquisite specificity, offering the potential of evaluating the breast cancer burden accurately.
Chem. Sci., 2015,6, 3906-3914
https://doi.org/10.1039/C5SC01054C
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Fiber-optic array using molecularly imprinted microspheres for antibiotic analysis
In this article we describe a new class of high-density optical microarrays based on molecularly imprinted microsphere sensors that directly incorporate specific recognition capabilities to detect enrofloxacin (ENRO), an antibiotic widely used for both human and veterinary applications.
Chem. Sci., 2015,6, 3139-3147
https://doi.org/10.1039/C5SC00115C
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In vivo evaluation of small-molecule thermoresponsive anticancer drugs potentiated by hyperthermia
Hyperthermia used as an adjuvant with chemotherapy is highly promising in the treatment of certain cancers.
Chem. Sci., 2015,6, 2795-2801
https://doi.org/10.1039/C5SC00613A
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Ratiometric detection of pH fluctuation in mitochondria with a new fluorescein/cyanine hybrid sensor
The first small-molecular ratiometric pH sensor with mitochondria targeting ability was constructed. With this sensor, the stimulated pHm fluctuation in MCF-7 cells was monitored via both fluorescence confocal microscopy and flow cytometry.
Chem. Sci., 2015,6, 3187-3194
https://doi.org/10.1039/C4SC04021J
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Highly stable and reusable imprinted artificial antibody used for in situ detection and disinfection of pathogens
We fabricate artificial antibodies based on imprinting technology and develop a sandwich ELISA for pathogen detection.
Chem. Sci., 2015,6, 2822-2826
https://doi.org/10.1039/C5SC00489F
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A mechanically interlocked molecular system programmed for the delivery of an anticancer drug
The development of mechanically interlocked molecular systems programmed to operate autonomously in biological environments is an emerging field of research with potential medicinal applications.
Chem. Sci., 2015,6, 2608-2613
https://doi.org/10.1039/C5SC00648A
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A dual-response BODIPY-based fluorescent probe for the discrimination of glutathione from cystein and homocystein
By employing a dual response approach, distinguishable fluorescence signals are initiated by GSH-mediated and Cys/Hcy-induced cascade reactions, thus allowing selective detection.
Chem. Sci., 2015,6, 2584-2589
https://doi.org/10.1039/C5SC00216H
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Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action
The RAPTA pharmacophore was linked to beads to identify its biomolecular targets in cancer cells.
Chem. Sci., 2015,6, 2449-2456
https://doi.org/10.1039/C4SC03905J
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Stereocontrolled protein surface recognition using chiral oligoamide proteomimetic foldamers
An oligoamide helix mimicking foldamer with well-defined conformation is shown to recognize its target protein hDM2 in a manner that depends upon the composition, spatial projection and stereochemistry of functional groups appended to the scaffold.
Chem. Sci., 2015,6, 2434-2443
https://doi.org/10.1039/C4SC03559C
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Label-free luminescence switch-on detection of hepatitis C virus NS3 helicase activity using a G-quadruplex-selective probe
A novel luminescent G-quadruplex-selective iridium(III) complex was employed in a label-free G-quadruplex-based detection assay for hepatitis C virus NS3 helicase activity.
Chem. Sci., 2015,6, 2166-2171
https://doi.org/10.1039/C4SC03319A
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A rationally designed small molecule for identifying an in vivo link between metal–amyloid-β complexes and the pathogenesis of Alzheimer's disease
An in vivo chemical tool designed to target metal−Aβ complexes and modulate their activity was applied to the 5XFAD mouse model of Alzheimer’s disease (AD) demonstrating the involvement of metal−Aβ in AD pathology.
Chem. Sci., 2015,6, 1879-1886
https://doi.org/10.1039/C4SC03239J
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Photostick: a method for selective isolation of target cells from culture
A new method enables optical selection of one or more cells in culture via photochemical crosslinking to the culture dish.
Chem. Sci., 2015,6, 1701-1705
https://doi.org/10.1039/C4SC03676J
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Dynamic tracking of pathogenic receptor expression of live cells using pyrenyl glycoanthraquinone-decorated graphene electrodes
Dynamic tracking of pathogenic receptor expression with live cells is made possible by pyrenyl glycoanthraquinones decorated on graphene electrodes.
Chem. Sci., 2015,6, 1996-2001
https://doi.org/10.1039/C4SC03614J
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Fluorescent/phosphorescent dual-emissive conjugated polymer dots for hypoxia bioimaging
Fluorescent/phosphorescent dual-emissive conjugated polymer dots were designed and synthesized, ere used for tumor hypoxia sensing via ratiometric imaging and photoluminescence lifetime imaging.
Chem. Sci., 2015,6, 1825-1831
https://doi.org/10.1039/C4SC03062A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Stimuli-responsive metal–organic frameworks gated by pillar[5]arene supramolecular switches
Mechanized monodisperse nano metal–organic frameworks (NMOFs) gated by carboxylatopillar[5]arene (CP5) switches with bio-friendly pH-triggered release capabilities were constructed for the first time as a new stimuli-responsive theranostic hybrid platform.
Chem. Sci., 2015,6, 1640-1644
https://doi.org/10.1039/C4SC03749A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Mesoporous silica nanoparticles for 19F magnetic resonance imaging, fluorescence imaging, and drug delivery
We described perfluorocarbon encapsulated in mesoporous silica nanoparticles which enabled dual modal imaging (NIR/19F MRI) and drug delivery.
Chem. Sci., 2015,6, 1986-1990
https://doi.org/10.1039/C4SC03549F
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Design of an intelligent sub-50 nm nuclear-targeting nanotheranostic system for imaging guided intranuclear radiosensitization
MR/UCL bimodal imaging guided intranuclear radiosensitization was firstly achieved by an intelligent nuclear-targeting nanotheranostic system.
Chem. Sci., 2015,6, 1747-1753
https://doi.org/10.1039/C4SC03080J
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Encapsulation of Pt(IV) prodrugs within a Pt(II) cage for drug delivery
This report describes a novel strategy for delivery of adamantyl-functionalized payloads using a supramolecular system, with a focus on Pt(IV) prodrugs.
Chem. Sci., 2015,6, 1189-1193
https://doi.org/10.1039/C4SC01892C
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers
Kinetically selective inhibitors of HDAC2 enhanced learning and memory in a CK-p25 mouse model of neurodegeneration.
Chem. Sci., 2015,6, 804-815
https://doi.org/10.1039/C4SC02130D
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
In vivo visible light-triggered drug release from an implanted depot
A visible light-degradable polymer allows on-demand in vivo photorelease of encapsulated dexamethasone from a subcutaneously implanted particle depot.
Chem. Sci., 2015,6, 335-341
https://doi.org/10.1039/C4SC02651A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Hyperbranched polydendrons: a new nanomaterials platform with tuneable permeation through model gut epithelium
Highly branched vinyl polymers (hyperbranched polydendrons), displaying combinations of dendritic and PEG end groups, have been synthesised using a mixed initiator approach. Nanoprecipitated polydendron particles have exhibited controlled permeation through a gut epithelium model.
Chem. Sci., 2015,6, 326-334
https://doi.org/10.1039/C4SC02889A
About this collection
To address major issues facing our planet and humanity, now and in the future, researchers all over the world have increasingly focused their energy and resources on finding solutions to these global challenges.
We are delighted to present this collection of articles recently published in Chemical Science, highlighting some of the excellent work that tackles important challenges related to global health and food.