Themed collection Articles behind our 2026 journal covers

The direct functionalization of unactivated C–H bonds has emerged as a promising strategy to achieve step-economical, atom-efficient, and environmentally benign chemical processes.

Diazo compounds are among the most popular intermediates in organic synthesis owing to the ease and versatility of generation of metal–carbenes.

Bicyclic boronic acids inhibit SME-1 carbapenemase via a unique π–π stacking with His105 and covalent interaction with Ser70.

For the first time, we developed a strategy for three-component tandem benzyl-C(sp³)–H activation via thermally-generated arynes with phenazine without a catalyst.

Single-stranded LNA/MOE mixmers and duplexes between intercalator-functionalized oligonucleotides and Xeno RNAs efficiently recognize double-stranded DNA with exceptional binding affinity.

Highly active α-glucosidase inhibitors (up to 41 times more potent than acarbose) were synthesised, mimicking ganocochlearines, tetracyclic Ganoderma alkaloids.

Heterocyclic scaffold-fusion of dimethoxy-DIBO yields photoactivatable pyrrolidine derivatives with efficient SPAAC reactivity, whereas triazole fusions produce nonreactive fluorophores.