RSC Advances  

Epoxides are oxygen containing three-membered heterocycles which can undergo ring opening reactions. These reactions have been significantly employed in the synthesis of alkaloids and terpenoids-based natural products.

Using a quinone monoacetal as the oxidant and DABCO as the base, we report the one-step synthesis of α-aryl-substituted pyrrolidines from pyrrolidine. The reaction of pyrrolidine and quinone monoacetal in 2,2,2-trifluoroethanol afforded octahydro-dipyrroloquinoline in high yield.

The new classification of APAP combinations (prodrugs, codrugs, and hybrids) was proposed. It makes a better understanding of the SAR studies for new pain relievers research and the design development for the analgesic APAP-based compounds.

Punicines were used as light-switchable collectors for flotation of the engineered artificial mineral lithium aluminate.

Recently, new pharmaceutical discoveries have become very important for addressing diverse health problems and protecting humanity.

Glycyrrhetinic acid, a triterpenoid compound primarily sourced from licorice root, as well as its derivatives produced through structural modification, exhibit noteworthy biological attributes, including anti-inflammatory, anti-tumor, antibacterial, antiviral, and antioxidant effects.

This review summarises the progress in aurone synthetic transformations, focusing on diverse cycloaddition ([3 + 2], [4 + 2], [4 + 3], [10 + 2]) and annulation reactions.

VEGF, an important category of tyrosine kinases, and its receptors (VEGFR) are hyper-activated in different cancers. The recently reported indolyl analogs with potential antineoplastic and VEGFR inhibitory properties are highlighted.

Spiro heterocycle frameworks are a class of organic compounds that possesses unique structural features making them highly sought-after targets in drug discovery due to their diverse biological and pharmacological activities.

In contrast to previous SAR studies of aza-compounds (23 vs. 24 and 25), the present study using analogues (26a–26c, 27c, and 28a–28c) of salacinol (1) revealed an essential role of the thiosugar ring in effectively inhibiting α-glucosidase.

Imidazopyridazines are fused heterocycles, like purines, with a pyridazine ring replacing the pyrimidine ring in purines.

Fused pyrrolo[2,1-a]isoquinolines have emerged as compelling molecules with remarkably potent cytotoxic activity and topoisomerase inhibitors.

Auranthine is a fungal benzodiazepine. Through the successful total synthesis of (±)-auranthine, we confirmed the refined structure of natural (−)-auranthine.

Thiazolines and their derivatives hold significant importance in the field of medicinal chemistry due to their promising potential as pharmaceutical agents.

2-Aryl-1H-naphtho[2,3-d]imidazole derivatives (1–15) were synthesized by condensing 2,3-diaminonaphthalene with variously substituted aldehydes and evaluated for their inhibitory potential against urease and antioxidant activities.

Research on the antimalarial effect of aminoalkyl chalcone derivatives against Plasmodium falciparum and Plasmodium knowlesi has bolstered efforts in drug discovery to combat cases of drug resistance.

This review highlighted recent advancements in the synthesis and biological importance of 1,3-diaryl-2-propen-1-ones. This review summarized the synthesis and biological importance of radiolabelled 1,3-diaryl-2-propen-1-ones as Aβ imaging probes for Alzheimer's disease.

Cloke–Wilson rearrangement is utilized to process cyclopropyl constituting functional groups and results in stable five-membered heterocycles. This rearrangement is also involved in the total synthesis of various natural products.

Gilman reagent (R₂CuLi) is a well-established reagent, having exceptional synthetic profile for the total synthesis of both abundant and scarce medicinally significant natural products.

Mansouramycin derivatives caused S phase cell cycle arrest and induced apoptosis in MBA-MB-231 cells，and a piperazine moiety introduced into the amino group at C-7 could improve the activities of mansouramycins.

After conducting an in silico analysis of the cryptic mdk cluster region and performing transcriptomic studies, an integrative Streptomyces BAC Vector containing the mdk gene sequence was constructed and heterologous expression yielded the angucyclic product seongomycin.

Halichlorine and pinnaic acids are structurally related to natural alkaloids isolated from different marine organisms. This review summarizes the asymmetric synthesis strategies of halichlorine and pinnaic acid using a 6-azaspiro[4.5]decane skeleton as the key intermediate.

Mukaiyama aldol reaction results in the highly enantioselective and diastereoselective synthesis of β-hydroxy carbonyls. Here, total syntheses of some natural products via this reaction as a key step have been presented.