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Themed collection New Talents

21 items
Editorial

Toxicology Research New Talents themed issue

Editor-in-Chief Nigel Gooderham introduces the New Talents themed issue of Toxicology Research.

Graphical abstract: Toxicology Research New Talents themed issue
From the themed collection: New Talents
Profile

Contributors to the New Talents issue

Profiles of the authors featured in this Toxicology Research themed issue.

Graphical abstract: Contributors to the New Talents issue
From the themed collection: New Talents
Viewpoint

Emerging toxicity models from emerging scientists

Emerging scientists joining the field of Toxicology bring with them novel and exciting approaches and models to assess toxicity.

Graphical abstract: Emerging toxicity models from emerging scientists
From the themed collection: New Talents
Review Article

Autophagy as the effector and player in DNA damage response of cells to genotoxicants

In this review, we provide an overview and discuss the molecular mechanism of DNA damage induced autophagy, and their mutual regulation and its role in cell fate determination in response to genotoxic effects of environmental toxicants.

Graphical abstract: Autophagy as the effector and player in DNA damage response of cells to genotoxicants
From the themed collection: New Talents
Review Article

Beyond a means of exposure: a new view of the mother in toxicology research

Toxicological studies generally view pregnant animals as a conduit through which gestational exposure of offspring to chemicals can be achieved, allowing for the study of developmental toxicity.

Graphical abstract: Beyond a means of exposure: a new view of the mother in toxicology research
From the themed collection: New Talents
Review Article

Metal toxicity and the p53 protein: an intimate relationship

The relationship between p53, ROS and transition metals.

Graphical abstract: Metal toxicity and the p53 protein: an intimate relationship
From the themed collection: New Talents
Review Article

Silver nanoparticles – wolves in sheep's clothing?

We review the cellular and molecular mechanisms behind silver nanoparticle toxicity and their intracellular fate. In addition, the role of silver ions in the toxicity of silver nanoparticles is discussed.

Graphical abstract: Silver nanoparticles – wolves in sheep's clothing?
From the themed collection: Nanotoxicology
Review Article

The Hepatic Reductase Null (HRN) and Reductase Conditional Null (RCN) mouse models as suitable tools to study metabolism, toxicity and carcinogenicity of environmental pollutants

This review describes the applicability of the Hepatic Reductase Null (HRN) and Reductase Conditional Null (RCN) mouse models to study carcinogen metabolism.

Graphical abstract: The Hepatic Reductase Null (HRN™) and Reductase Conditional Null (RCN) mouse models as suitable tools to study metabolism, toxicity and carcinogenicity of environmental pollutants
From the themed collection: New Talents
Paper

Euphorbia tirucalli aqueous extract induces cytotoxicity, genotoxicity and changes in antioxidant gene expression in human leukocytes

The medicinal use of Euphorbia tirucalli has to be made with caution, as our study indicates that the aqueous extract induces genotoxicity and cytotoxicity in human leukocytes

Graphical abstract: Euphorbia tirucalli aqueous extract induces cytotoxicity, genotoxicity and changes in antioxidant gene expression in human leukocytes
From the themed collection: New Talents
Paper

Effects of benzo[a]pyrene on mouse germ cells: heritable DNA mutation, testicular cell hypomethylation and their interaction with nucleotide excision repair

Benzo[a]pyrene induces heritable mutations in male germ cells.

Graphical abstract: Effects of benzo[a]pyrene on mouse germ cells: heritable DNA mutation, testicular cell hypomethylation and their interaction with nucleotide excision repair
From the themed collection: New Talents
Paper

Rescue of cells from apoptosis increases DNA repair in UVB exposed cells: implications for the DNA damage response

Classically, the nucleotide excision repair (NER) of cyclobutane pyrimidine dimers (CPD) is a lengthy process (t1/2 > 48 h).

Graphical abstract: Rescue of cells from apoptosis increases DNA repair in UVB exposed cells: implications for the DNA damage response
From the themed collection: New Talents
Open Access Paper

Reproductive toxicity and meiotic dysfunction following exposure to the pesticides Maneb, Diazinon and Fenarimol

The comprehensive identification and mechanistic analysis of reproductive toxicants constitutes one of the major hurdles in the toxicological assessment of chemicals.

Graphical abstract: Reproductive toxicity and meiotic dysfunction following exposure to the pesticides Maneb, Diazinon and Fenarimol
From the themed collection: Open Access articles from Toxicology Research
Paper

Effect of diselenide administration in thioacetamide-induced acute neurological and hepatic failure in mice

Hepatic encephalopathy is a common complication of severe acute hepatic failure and has been associated with high short-term mortality rates.

Graphical abstract: Effect of diselenide administration in thioacetamide-induced acute neurological and hepatic failure in mice
From the themed collection: New Talents
Open Access Paper

Quantum dot induced cellular perturbations involving varying toxicity pathways

Quantum dots (QD) with varying surface chemistry can have an impact on cellular uptake and a range of indicators for cell perturbation.

Graphical abstract: Quantum dot induced cellular perturbations involving varying toxicity pathways
From the themed collection: Nanotoxicology
Paper

In vitro screening of environmental chemicals identifies zearalenone as a novel substrate of the placental BCRP/ABCG2 transporter

The BCRP (ABCG2) transporter is responsible for the efflux of chemicals from the placenta to the maternal circulation.

Graphical abstract: In vitro screening of environmental chemicals identifies zearalenone as a novel substrate of the placental BCRP/ABCG2 transporter
From the themed collection: New Talents
Paper

Eugenia uniflora leaves essential oil induces toxicity in Drosophila melanogaster: involvement of oxidative stress mechanisms

Eugenia uniflora L. (Myrtaceae family), also known as “pitanga”, is a tree species widely used in popular medicine.

Graphical abstract: Eugenia uniflora leaves essential oil induces toxicity in Drosophila melanogaster: involvement of oxidative stress mechanisms
From the themed collection: New Talents
Paper

Bisphenol-A exposure alters memory consolidation and hippocampal CA1 spine formation through Wnt signaling in vivo and in vitro

Based on Wnt signaling pathway, this study aims to further mechanistically understand memory alteration after BPA exposure.

Graphical abstract: Bisphenol-A exposure alters memory consolidation and hippocampal CA1 spine formation through Wnt signaling in vivo and in vitro
From the themed collection: New Talents
Paper

New approaches to advance the use of genetic toxicology analyses for human health risk assessment

Genetic toxicology testing has a crucial role in the safety assessment of substances of societal value by reducing human exposure to potential somatic and germ cell mutagens.

Graphical abstract: New approaches to advance the use of genetic toxicology analyses for human health risk assessment
From the themed collection: New Talents
Paper

HBCD and PCBs enhance the cell migration and invasion of HepG2 via the PI3 K/Akt pathway

Exposure to hexabromocyclododecane (HBCD) and polychlorinated biphenyls (PCBs) has been proved to result in diversified toxicity, including cancerogenesis.

Graphical abstract: HBCD and PCBs enhance the cell migration and invasion of HepG2 via the PI3 K/Akt pathway
From the themed collection: New Talents
Paper

Uptake of gold nanoparticles in primary human endothelial cells

Single-particle resolution techniques show that endothelial cells internalise 80 nm unmodified gold nanoparticles by endocytosis with subsequent transport to vesicles.

Graphical abstract: Uptake of gold nanoparticles in primary human endothelial cells
Open Access Paper

Toxicity of arsenite and thio-DMAV after long-term (21 days) incubation of human urothelial cells: cytotoxicity, genotoxicity and epigenetics

This study aims to further mechanistically understand toxic modes of action after chronic arsenic species exposure.

Graphical abstract: Toxicity of arsenite and thio-DMAV after long-term (21 days) incubation of human urothelial cells: cytotoxicity, genotoxicity and epigenetics
From the themed collection: Open Access articles from Toxicology Research
21 items

About this collection

This Themed Issue of Toxicology Research showcases the work being conducted by New Talents in toxicology across the globe. It highlights up-and-coming scientists in the early stages of their independent careers, who are internationally recognised for making outstanding contributions to the field.

Spotlight

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