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Themed collection Toxicology Research 2018 Most Downloaded Articles

10 items
Open Access Review Article

The association between chemical-induced porphyria and hepatic cancer

The haem biosynthetic pathway is of fundamental importance for cellular metabolism both for the erythroid and nonerythroid tissues.

Graphical abstract: The association between chemical-induced porphyria and hepatic cancer
From the themed collection: Recent Review Articles
Review Article

Paracetamol metabolism, hepatotoxicity, biomarkers and therapeutic interventions: a perspective

After over 60 years of therapeutic use in the UK, paracetamol (acetaminophen, N-acetyl-p-aminophenol, APAP) remains the subject of considerable research into both its mode of action and toxicity.

Graphical abstract: Paracetamol metabolism, hepatotoxicity, biomarkers and therapeutic interventions: a perspective
From the themed collection: Recent Review Articles
Open Access Paper

In silico identification of protein targets for chemical neurotoxins using ToxCast in vitro data and read-across within the QSAR toolbox

This study evaluates the application of QSAR Toolbox and ToxCast screening data to identify neurological targets for pyrethroids.

Graphical abstract: In silico identification of protein targets for chemical neurotoxins using ToxCast in vitro data and read-across within the QSAR toolbox
Open Access Paper

The systemic toxicity of heavy metal mixtures in rats

To explore the health effects of multi-heavy metal exposure, Sprague Dawley (SD) rats were orally given one dose of heavy metal mixtures (HMMs).

Graphical abstract: The systemic toxicity of heavy metal mixtures in rats
Paper

Systematic toxicity investigation of graphene oxide: evaluation of assay selection, cell type, exposure period and flake size

Dosage, size, exposure time and cell line dependent cytotoxicity of graphene oxide.

Graphical abstract: Systematic toxicity investigation of graphene oxide: evaluation of assay selection, cell type, exposure period and flake size
Paper

Risk assessment of inhalation exposure to VOCs in dwellings in Chongqing, China

This paper investigated the concentrations of eight types of indoor VOCs – benzene, toluene, xylenes, butyl acetate, styrene, isopropylbenzene, undecane and formaldehyde.

Graphical abstract: Risk assessment of inhalation exposure to VOCs in dwellings in Chongqing, China
Paper

Bifenthrin-induced neurotoxicity in rats: involvement of oxidative stress

Extensive use of synthetic pyrethroids has resulted in serious human health issues.

Graphical abstract: Bifenthrin-induced neurotoxicity in rats: involvement of oxidative stress
Paper

Protective effects of Nigella sativa L. seed extract on lead induced neurotoxicity during development and early life in mouse models

Nigella sativa L. supplementation improves Pb-induced neurotoxicity in early life and provides neuroprotective and antioxidant potentials.

Graphical abstract: Protective effects of Nigella sativa L. seed extract on lead induced neurotoxicity during development and early life in mouse models
Paper

Paper supported long-term 3D liver co-culture model for the assessment of hepatotoxic drugs

A paper-based 3D liver co-culture model was described for the long term maintenance of liver specific functions and the evaluation of drug induced hepatotoxicity.

Graphical abstract: Paper supported long-term 3D liver co-culture model for the assessment of hepatotoxic drugs
Paper

The effect of bisphenol A on testicular steroidogenesis and its amelioration by quercetin: an in vivo and in silico approach

Bisphenol A (BPA), a phenyl ring containing synthetic xenoestrogen, is widely used in the manufacture of polycarbonate plastics, epoxy resins and as a non-polymer additive to other plastics.

Graphical abstract: The effect of bisphenol A on testicular steroidogenesis and its amelioration by quercetin: an in vivo and in silico approach
10 items

About this collection

This themed collection features the top 10 most downloaded articles published in Toxicology Research in 2018. Congratulations to all of the authors whose articles have been featured.

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