The association between chemical-induced porphyria and hepatic cancer
The haem biosynthetic pathway is of fundamental importance for cellular metabolism both for the erythroid and nonerythroid tissues.
Paracetamol metabolism, hepatotoxicity, biomarkers and therapeutic interventions: a perspective
After over 60 years of therapeutic use in the UK, paracetamol (acetaminophen, N-acetyl-p-aminophenol, APAP) remains the subject of considerable research into both its mode of action and toxicity.
In silico identification of protein targets for chemical neurotoxins using ToxCast in vitro data and read-across within the QSAR toolbox
This study evaluates the application of QSAR Toolbox and ToxCast screening data to identify neurological targets for pyrethroids.
The systemic toxicity of heavy metal mixtures in rats
To explore the health effects of multi-heavy metal exposure, Sprague Dawley (SD) rats were orally given one dose of heavy metal mixtures (HMMs).
Systematic toxicity investigation of graphene oxide: evaluation of assay selection, cell type, exposure period and flake size
Dosage, size, exposure time and cell line dependent cytotoxicity of graphene oxide.
Risk assessment of inhalation exposure to VOCs in dwellings in Chongqing, China
This paper investigated the concentrations of eight types of indoor VOCs – benzene, toluene, xylenes, butyl acetate, styrene, isopropylbenzene, undecane and formaldehyde.
Bifenthrin-induced neurotoxicity in rats: involvement of oxidative stress
Extensive use of synthetic pyrethroids has resulted in serious human health issues.
Protective effects of Nigella sativa L. seed extract on lead induced neurotoxicity during development and early life in mouse models
Nigella sativa L. supplementation improves Pb-induced neurotoxicity in early life and provides neuroprotective and antioxidant potentials.
Paper supported long-term 3D liver co-culture model for the assessment of hepatotoxic drugs
A paper-based 3D liver co-culture model was described for the long term maintenance of liver specific functions and the evaluation of drug induced hepatotoxicity.
The effect of bisphenol A on testicular steroidogenesis and its amelioration by quercetin: an in vivo and in silico approach
Bisphenol A (BPA), a phenyl ring containing synthetic xenoestrogen, is widely used in the manufacture of polycarbonate plastics, epoxy resins and as a non-polymer additive to other plastics.
About this collection
This themed collection features the top 10 most downloaded articles published in Toxicology Research in 2018. Congratulations to all of the authors whose articles have been featured.