Themed collection Advances in Optical and Electrochemical Techniques for Biomedical Imaging

Yi-Tao Long and Thomas J. Meade introduce the Chemical Science retrospective themed collection on advances in optical and electrochemical techniques for biomedical imaging.

Surface-enhanced Raman spectroscopy (SERS) is a vibrational spectroscopy technique with sensitivity down to the single molecule level that provides fine molecular fingerprints, allowing for direct identification of target analytes.

Interrogating living cells requires sensitive imaging of a large number of components in real time.

This minireview summarizes the recent achievements of electrochemical imaging platforms to map cellular functions in biological specimens using electrochemical scanning nano/micro-probe microscopy and 2D chips containing microelectrode arrays.

A review of recent advances in near-infrared II fluorophores for multifunctional biomedical imaging.

Tetraphenylethylene nanocrystals as new ECL emitters with near-infrared aggregation-induced enhanced electrochemiluminescence exhibited high ECL efficiency and excellent biocompatibility.

Spatiotemporal resolved electrocatalytic activity on single 2D gold nanoplates was imaged via electrogenerated chemiluminescence microscopy.

A near-infrared fluorescent probe was exploited to sensitively visualize ozone in the brains of mice with depression phenotypes in situ.

A super-contrast NIR-II fluorophore IR-BEMC6P with enhanced quantum yield is developed and the excretion mechanism is identified.

Convolutional neural networks directly learned chemical information from the periodic table to predict the enthalpy of formation and compound stability.

Dynamically imaging stochastic collision electrochemistry of single nanoparticles by electrochemiluminescence microscopy enables visualization of diverse collision behaviours.

Dark Quencher, IRDye QC1 in nanoemulsion form offers excellent optoacoustic performance, suitable for non-invasive pre-clinical optoacoustic imaging.

Monochromatic dark-field microscopy coupled with high-frequency potential modulation leads to non-faradaic electrochemical impedance spectroscopy of single Au nanorods.

Detection of a live 3D tumour model through 15 mm of tissue using SESORRS.

The first water-soluble NIR AIEgen was synthesized and used for ultrafast wash-free cellular imaging and photodynamic cancer cell ablation.

PDFT1032, a new semiconducting polymer possessing a favorable absorption peak (1032 nm) and outstanding biocompatibility, may be widely applicable in clinical imaging and the surgical treatment of malignancy.

Enantiopure single crystals of extended metal atom chains display exceptionally large optical X-ray dichroisms at the Co K-edge.

Here, we introduce a unique high-throughput infrared (IR) microscopy method that combines automated image correction and subsequent spectral data analysis for 3D-IR image reconstruction.