A renaissance of ligand-to-metal charge transfer by cerium photocatalysis
Diverse alcohols, serving as substrates or co-catalysts, and Ce(IV) achieve photoinduced LMCT to generate highly active alkoxy radicals, which opens a new avenue for many difficult HAT reactions.
Multi-catalyst promoted asymmetric relay reactions
In this highlight, cooperative multi-catalyst systems, especially bismetallic- and organo-catalyst mediated asymmetric relay reactions, are presented.
Striving to exploit alkyl electrophiles: challenge and choice in transition metal-catalyzed cross-coupling reactions of sulfones
Transition metal-catalyzed cross-coupling reactions of alkyl sulfones as crystalline and readily available alkyl electrophiles via a radical process are highlighted.
Transition-metal-catalyzed decarbonylation of carboxylic acids to olefins: exploiting acyl C–O activation for the production of high value products
In this article, we review the recent developments in the transition-metal-catalyzed decarbonylation of carboxylic acids to produce olefins by the formal acyl C–O activation mechanism and discuss future challenges in this field.
Direct functionalization of benzylic and non-benzylic C(sp3)–H bonds via keteniminium ion initiated cascade [1,5]-hydrogen transfer/cyclization
Keteniminium intermediates generated in situ initiate the cascade [1,5]-hydride transfer/cyclization for the direct functionalization of benzylic and non-benzylic C(sp3)–H bonds.
Total synthesis of strictamine: a tutorial for novel and efficient synthesis
The novelty and efficiency of the overall synthetic route are the key values being imparted to the younger generation of synthetic chemists. In this Highlights, synthesis of strictamine was tutored to students on the creativity of synthetic design.
Catalytic approaches to assemble cyclobutane motifs in natural product synthesis
New strategies based on transition-metal catalysis or organocatalysis have provided new perspectives into the total synthesis of cyclobutane-containing natural products.
Heteropore covalent organic frameworks: a new class of porous organic polymers with well-ordered hierarchical porosities
This review highlights the development of heteropore covalent organic frameworks, a new class of porous organic polymers which exhibit well-ordered heterogeneous/hierarchical porosities.
Selective modification of natural nucleophilic residues in peptides and proteins using arylpalladium complexes
The present review outlines the recent methodologies for selective arylation of natural nucleophilic residues within unprotected peptides and proteins promoted by arylpalladium complexes, which demonstrate the advantages and potential of organometallic palladium complexes in bioconjugation.
Olefin metathesis reaction as a locking tool for macrocycle and mechanomolecule construction
The present review deals with an updated visit to the olefin metathesis reaction as a powerful tool for the construction of sophisticated macromolecular architectures.
Supramolecular gelatons: towards the design of molecular gels
The concept of supramolecular gelatons for the design of gels was proposed and described.
Carbocyclization approaches to electron-deficient nanographenes and their analogues
Versatile π-aromatic building blocks and selective coupling transformations enable rapid assembly of complex electron-deficient molecules, useful as n-type organic semiconductors.
This review article highlights the emergence of eclectic molecular design principles to realize remarkably strong electron deficient arylenediimide molecules, aspects of their stability and associated applications.
Controllable synthetic ion channels
The controllable synthetic ion channels with voltage-, ligand- light- and mechano-gating, as well as rectifying behaviours are discussed in regarding to their construction strategies and functions.
Catalytic enantioselective synthesis of α-chiral azides
The catalytic asymmetric synthesis of α-chiral azides is of current interest and three synthetic strategies have been developed. This review summarizes the recent progress in this research area, discusses the advantages and limitations of each strategy, and outlines synthetic opportunities for future research.
Carbonyl–olefin metathesis: a key review
In organic chemistry, olefin–olefin metathesis of two unsaturated substrates for the formation of a new carbon–carbon bond has been widely explored and applied.
Recent synthetic studies towards natural products via [5 + 2] cycloaddition reactions
In this review, we provide a summary of recent progress regarding synthetic studies towards natural products via [5 + 2] cycloaddition reactions.
Recent advances in the intramolecular Mannich reaction in natural products total synthesis
This review focuses on selected applications of the intramolecular Mannich reaction as a key step in the total synthesis of natural products (2000–2017).
Cycloaddition/annulation strategies for the construction of multisubstituted pyrrolidines and their applications in natural product synthesis
Pyrrolidines are privileged substructures of numerous bioactive natural products and drugs.
This review introduces the interplay of anion coordination and supramolecular self-assembly, presenting recent progress in anion-induced and anion-coordination-based self-assemblies.
Insertion of sulfur dioxide via a radical process: an efficient route to sulfonyl compounds
This review is focused on the recent advances in the chemistry of sulfur dioxide fixation through a radical process. Diverse sulfonyl compounds can be obtained efficiently under mild conditions.
Formation of tetrasubstituted C–C double bonds via olefin metathesis: challenges, catalysts, and applications in natural product synthesis
Among the many types of transition-metal-catalysed C–C bond forming reactions, olefin metathesis is without a doubt one of the most thriving fields in modern organic synthetic chemistry.
Pyridinium salts: from synthesis to reactivity and applications
This review highlights the pyridinium salts in terms of their natural occurrence, synthesis, reactivity, biological properties, and diverse applications.
Recent developments in palladium-catalysed non-directed coupling of (hetero)arene C–H bonds with C–Z (Z = B, Si, Sn, S, N, C, H) bonds in bi(hetero)aryl synthesis
This review article describes the palladium-catalysed non-directed coupling of (hetero)arene C–H bonds with C(Ar)–Z (Z = B, Si, Sn, S, N, C, H) bonds for facile bi(hetero)aryl synthesis in the past 10 years.
Total syntheses of pyrroloazocine indole alkaloids: challenges and reaction discovery
Total syntheses of pyrroloazocine indole alkaloids (lapidilectines, grandilodines, lundurines and tenuisines) are discussed in terms of existing retrosynthetic solutions and novel reaction discoveries.
Asymmetric hydrofunctionalization of minimally functionalized alkenes via earth abundant transition metal catalysis
The development of earth-abundant transition metal-catalysed highly enantioselective hydrofunctionalization of minimally functionalized alkenes was summarized.
Ir-Catalyzed reactions in natural product synthesis
This review highlights the recent applications of Ir-catalyzed reactions in the total synthesis of natural products.
Total synthesis of natural products via iridium catalysis
An overview of the highlights in total synthesis of natural products using iridium as a catalyst is given.