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Themed collection 2018 Organic Chemistry Frontiers Review-type Articles

28 items
Highlight

A renaissance of ligand-to-metal charge transfer by cerium photocatalysis

Diverse alcohols, serving as substrates or co-catalysts, and Ce(IV) achieve photoinduced LMCT to generate highly active alkoxy radicals, which opens a new avenue for many difficult HAT reactions.

Graphical abstract: A renaissance of ligand-to-metal charge transfer by cerium photocatalysis
Highlight

Multi-catalyst promoted asymmetric relay reactions

In this highlight, cooperative multi-catalyst systems, especially bismetallic- and organo-catalyst mediated asymmetric relay reactions, are presented.

Graphical abstract: Multi-catalyst promoted asymmetric relay reactions
Highlight

Striving to exploit alkyl electrophiles: challenge and choice in transition metal-catalyzed cross-coupling reactions of sulfones

Transition metal-catalyzed cross-coupling reactions of alkyl sulfones as crystalline and readily available alkyl electrophiles via a radical process are highlighted.

Graphical abstract: Striving to exploit alkyl electrophiles: challenge and choice in transition metal-catalyzed cross-coupling reactions of sulfones
Highlight

Transition-metal-catalyzed decarbonylation of carboxylic acids to olefins: exploiting acyl C–O activation for the production of high value products

In this article, we review the recent developments in the transition-metal-catalyzed decarbonylation of carboxylic acids to produce olefins by the formal acyl C–O activation mechanism and discuss future challenges in this field.

Graphical abstract: Transition-metal-catalyzed decarbonylation of carboxylic acids to olefins: exploiting acyl C–O activation for the production of high value products
Highlight

Direct functionalization of benzylic and non-benzylic C(sp3)–H bonds via keteniminium ion initiated cascade [1,5]-hydrogen transfer/cyclization

Keteniminium intermediates generated in situ initiate the cascade [1,5]-hydride transfer/cyclization for the direct functionalization of benzylic and non-benzylic C(sp3)–H bonds.

Graphical abstract: Direct functionalization of benzylic and non-benzylic C(sp3)–H bonds via keteniminium ion initiated cascade [1,5]-hydrogen transfer/cyclization
Highlight

Total synthesis of strictamine: a tutorial for novel and efficient synthesis

The novelty and efficiency of the overall synthetic route are the key values being imparted to the younger generation of synthetic chemists. In this Highlights, synthesis of strictamine was tutored to students on the creativity of synthetic design.

Graphical abstract: Total synthesis of strictamine: a tutorial for novel and efficient synthesis
Highlight

Catalytic approaches to assemble cyclobutane motifs in natural product synthesis

New strategies based on transition-metal catalysis or organocatalysis have provided new perspectives into the total synthesis of cyclobutane-containing natural products.

Graphical abstract: Catalytic approaches to assemble cyclobutane motifs in natural product synthesis
Review Article

Heteropore covalent organic frameworks: a new class of porous organic polymers with well-ordered hierarchical porosities

This review highlights the development of heteropore covalent organic frameworks, a new class of porous organic polymers which exhibit well-ordered heterogeneous/hierarchical porosities.

Graphical abstract: Heteropore covalent organic frameworks: a new class of porous organic polymers with well-ordered hierarchical porosities
Review Article

Selective modification of natural nucleophilic residues in peptides and proteins using arylpalladium complexes

The present review outlines the recent methodologies for selective arylation of natural nucleophilic residues within unprotected peptides and proteins promoted by arylpalladium complexes, which demonstrate the advantages and potential of organometallic palladium complexes in bioconjugation.

Graphical abstract: Selective modification of natural nucleophilic residues in peptides and proteins using arylpalladium complexes
Review Article

Olefin metathesis reaction as a locking tool for macrocycle and mechanomolecule construction

The present review deals with an updated visit to the olefin metathesis reaction as a powerful tool for the construction of sophisticated macromolecular architectures.

Graphical abstract: Olefin metathesis reaction as a locking tool for macrocycle and mechanomolecule construction
Review Article

Supramolecular gelatons: towards the design of molecular gels

The concept of supramolecular gelatons for the design of gels was proposed and described.

Graphical abstract: Supramolecular gelatons: towards the design of molecular gels
Review Article

Carbocyclization approaches to electron-deficient nanographenes and their analogues

Versatile π-aromatic building blocks and selective coupling transformations enable rapid assembly of complex electron-deficient molecules, useful as n-type organic semiconductors.

Graphical abstract: Carbocyclization approaches to electron-deficient nanographenes and their analogues
Review Article

Electron-poor arylenediimides

This review article highlights the emergence of eclectic molecular design principles to realize remarkably strong electron deficient arylenediimide molecules, aspects of their stability and associated applications.

Graphical abstract: Electron-poor arylenediimides
Review Article

Controllable synthetic ion channels

The controllable synthetic ion channels with voltage-, ligand- light- and mechano-gating, as well as rectifying behaviours are discussed in regarding to their construction strategies and functions.

Graphical abstract: Controllable synthetic ion channels
Review Article

Catalytic enantioselective synthesis of α-chiral azides

The catalytic asymmetric synthesis of α-chiral azides is of current interest and three synthetic strategies have been developed. This review summarizes the recent progress in this research area, discusses the advantages and limitations of each strategy, and outlines synthetic opportunities for future research.

Graphical abstract: Catalytic enantioselective synthesis of α-chiral azides
Review Article

Carbonyl–olefin metathesis: a key review

In organic chemistry, olefin–olefin metathesis of two unsaturated substrates for the formation of a new carbon–carbon bond has been widely explored and applied.

Graphical abstract: Carbonyl–olefin metathesis: a key review
Review Article

Recent synthetic studies towards natural products via [5 + 2] cycloaddition reactions

In this review, we provide a summary of recent progress regarding synthetic studies towards natural products via [5 + 2] cycloaddition reactions.

Graphical abstract: Recent synthetic studies towards natural products via [5 + 2] cycloaddition reactions
Review Article

Recent advances in the intramolecular Mannich reaction in natural products total synthesis

This review focuses on selected applications of the intramolecular Mannich reaction as a key step in the total synthesis of natural products (2000–2017).

Graphical abstract: Recent advances in the intramolecular Mannich reaction in natural products total synthesis
Review Article

Cycloaddition/annulation strategies for the construction of multisubstituted pyrrolidines and their applications in natural product synthesis

Pyrrolidines are privileged substructures of numerous bioactive natural products and drugs.

Graphical abstract: Cycloaddition/annulation strategies for the construction of multisubstituted pyrrolidines and their applications in natural product synthesis
Review Article

Anion-coordination-directed self-assemblies

This review introduces the interplay of anion coordination and supramolecular self-assembly, presenting recent progress in anion-induced and anion-coordination-based self-assemblies.

Graphical abstract: Anion-coordination-directed self-assemblies
Review Article

Insertion of sulfur dioxide via a radical process: an efficient route to sulfonyl compounds

This review is focused on the recent advances in the chemistry of sulfur dioxide fixation through a radical process. Diverse sulfonyl compounds can be obtained efficiently under mild conditions.

Graphical abstract: Insertion of sulfur dioxide via a radical process: an efficient route to sulfonyl compounds
Review Article

Formation of tetrasubstituted C–C double bonds via olefin metathesis: challenges, catalysts, and applications in natural product synthesis

Among the many types of transition-metal-catalysed C–C bond forming reactions, olefin metathesis is without a doubt one of the most thriving fields in modern organic synthetic chemistry.

Graphical abstract: Formation of tetrasubstituted C–C double bonds via olefin metathesis: challenges, catalysts, and applications in natural product synthesis
Review Article

Pyridinium salts: from synthesis to reactivity and applications

This review highlights the pyridinium salts in terms of their natural occurrence, synthesis, reactivity, biological properties, and diverse applications.

Graphical abstract: Pyridinium salts: from synthesis to reactivity and applications
Review Article

Recent developments in palladium-catalysed non-directed coupling of (hetero)arene C–H bonds with C–Z (Z = B, Si, Sn, S, N, C, H) bonds in bi(hetero)aryl synthesis

This review article describes the palladium-catalysed non-directed coupling of (hetero)arene C–H bonds with C(Ar)–Z (Z = B, Si, Sn, S, N, C, H) bonds for facile bi(hetero)aryl synthesis in the past 10 years.

Graphical abstract: Recent developments in palladium-catalysed non-directed coupling of (hetero)arene C–H bonds with C–Z (Z = B, Si, Sn, S, N, C, H) bonds in bi(hetero)aryl synthesis
Open Access Review Article

Total syntheses of pyrroloazocine indole alkaloids: challenges and reaction discovery

Total syntheses of pyrroloazocine indole alkaloids (lapidilectines, grandilodines, lundurines and tenuisines) are discussed in terms of existing retrosynthetic solutions and novel reaction discoveries.

Graphical abstract: Total syntheses of pyrroloazocine indole alkaloids: challenges and reaction discovery
Review Article

Asymmetric hydrofunctionalization of minimally functionalized alkenes via earth abundant transition metal catalysis

The development of earth-abundant transition metal-catalysed highly enantioselective hydrofunctionalization of minimally functionalized alkenes was summarized.

Graphical abstract: Asymmetric hydrofunctionalization of minimally functionalized alkenes via earth abundant transition metal catalysis
Review Article

Ir-Catalyzed reactions in natural product synthesis

This review highlights the recent applications of Ir-catalyzed reactions in the total synthesis of natural products.

Graphical abstract: Ir-Catalyzed reactions in natural product synthesis
Review Article

Total synthesis of natural products via iridium catalysis

An overview of the highlights in total synthesis of natural products using iridium as a catalyst is given.

Graphical abstract: Total synthesis of natural products via iridium catalysis
28 items

About this collection

Critical reviews and highlight articles published in  Organic Chemistry Frontiers  during 2018 are collated as below for the benefit of readers.

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