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Issue 9, 2018
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Catalytic enantioselective synthesis of α-chiral azides

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α-Chiral azides represent a special subclass of chiral amines, which not only widely exist in bioactive compounds but also play a significant role as a building block in a variety of value-added chiral products. The catalytic asymmetric synthesis of α-chiral azides is of current interest and three synthetic strategies have been developed. This review summarizes the recent progress in this research area, discusses the advantages and limitations of each strategy, and outlines synthetic opportunities for future research.

Graphical abstract: Catalytic enantioselective synthesis of α-chiral azides

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Publication details

The article was received on 27 Feb 2018, accepted on 26 Mar 2018 and first published on 27 Mar 2018

Article type: Review Article
DOI: 10.1039/C8QO00138C
Citation: Org. Chem. Front., 2018,5, 1542-1559

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    Catalytic enantioselective synthesis of α-chiral azides

    P. Ding, X. Hu, F. Zhou and J. Zhou, Org. Chem. Front., 2018, 5, 1542
    DOI: 10.1039/C8QO00138C

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