Themed collection Articles behind our 2025 journal covers

Aziridine is a fascinating core which enables synthesis of diverse N-heterocycles comprising natural product analogs and pharmaceutical candidates.

Nitrogen bridgehead (NBH) is present in many natural products, but studies of synthetic analogues remain unexplored. This review gives an overview of NBH for potential applications.

Solid-state NMR spectra of ¹³C- and ¹⁹F-labelled amphotericin B reveal that seven molecules form an ion channel assembly with ergosterol. Molecular dynamics simulations show this channel generates ion currents consistent with experiments.

Synthesis approaches for tecovirimat API, highlighting pros and cons, summarizing processes for key intermediates, including cycloheptatriene, and evaluating feasibility, efficiency, and environmental sustainability.

A fluorescent thymine analogue, ^ThexT, enables visualisation of immunostimulatory CpG oligonucleotides in macrophages. Its incorporation site affects TLR9 activation, offering insights into immune response modulation and intracellular DNA tracking.

A straightforward synthetic strategy toward three β-meso-fused porphyrin–pyrene conjugates is presented. The five-ring fused molecules possess intriguing absorption properties and electronics, which are probed spectroscopically and by theory.

A multidisciplinary study of purine nucleoside selective BuChE inhibitors, covering docking, synthesis, biological evaluation and cytotoxic assays.

6,8-Ditrifluoromethyl halogenated phenazine potently eradicates Gram-positive bacterial biofilm communities that demonstrate innate tolerance to all classes of conventional antibiotics.

A redox-neutral mechanism for Zn-catalyzed Suzuki–Miyaura cross coupling reaction.

Reductive amination of triglycerides under mild conditions was achieved using a titanium oxide-supported Pt–Mo catalyst. Various triglycerides including cooking oil are transformed into their corresponding fatty amines.

A dialkoxybenzyl linker for the synthesis of peptide hydrazides, with a selective cleavage property, enhances HPLC purification efficiency.

A simple, sustainable and scalable electrochemical method providing direct access to a highly diverse range of 3-(acylamidoalkyl)-2,1-benzisoxazoles by cathodic reduction of widely accessible nitro arenes was established.

Selective oxidation of alcohols was achieved by analyzing the yields of carboxylic acids as a function of weight hourly space velocity.

A protocol for synthesizing 3-thiomethyl substituted benzofuran derivatives via cyclization of 2-alkynyl anisole using DMTSF as the electrophile was developed.

A metal, base and additive free C–O bond formation strategy for the synthesis of oxime ethers from various oxime derivatives and tertiary and secondary aryl alcohols in the presence of HFIP at 30 °C is developed.

Stereoselective syntheses of 16 triazole-based 1-deoxysphingosine dual SphK inhibitors incorporating different systematic modifications highlight heptafluoropropyl and guanidinium motifs towards improving SphK2 inhibition.

Heteroduplexes comprised of densely intercalator-modified oligodeoxyribonucleotides and LNAs (locked nucleic acids) enable highly specific mixed-sequence recognition of double-stranded DNA regions.

An unfolding–refolding cycle of albumin is accomplished by using a pH jump based on the time-dependent decarboxylation of nitroacetic acid.