Themed collection Emerging Investigators
Medicinal chemistry of the myeloid C-type lectin receptors Mincle, Langerin, and DC-SIGN
This review outlines the current state of research into glycomimetic or drug-like small molecule ligands for the C-type lectin receptors Mincle, Langerin, and DC-SIGN, which have potential applications in vaccine research and anti-infective therapy.
β-Lactam antibiotic targets and resistance mechanisms: from covalent inhibitors to substrates
Overview of β-lactam antibiotics and the proteins with which they covalently interact, focusing on penicillin-binding proteins and serine β-lactamases.
Uptake mechanisms of cell-internalizing nucleic acid aptamers for applications as pharmacological agents
Selection methods in generating cell-internalizing nucleic acid aptamer via cell-SELEX technique for applications in diagnostics and therapeutics are discussed. Their challenges, optimization strategies and cellular uptake mechanisms are presented.
Macrocyclization strategies for cyclic peptides and peptidomimetics
Macrocyclization between head, tail or sidechains is a frequently employed strategy to enhance peptide and peptidomimetic stability, selectivity and affinity.
De novo molecular drug design benchmarking
Deep neural networks (DNNs) used for de novo drug design have different architectures and hyperparameters that impact the final output of suggested drug candidates. Herein we review benchmarking platforms that assess the utility and validity of DNNs.
Targeting the protease of West Nile virus
Protease inhibitors of West Nile virus have long suffered from insufficient drug likeness, which has been tackled in latest advancements.
Human carboxylesterases and fluorescent probes to image their activity in live cells
In this review, drug metabolizing human carboxylesterases and fluorescent probes capable of studying their activity in live cells are discussed.
Cyclisation strategies for stabilising peptides with irregular conformations
There are remarkably few examples of designing cyclic constraints for peptides which adopt an irregular conformation in their bioactive state. We discuss the design strategies, opportunities and challenges for this underexplored class of inhibitors.
The right tools for the job: the central role for next generation chemical probes and chemistry-based target deconvolution methods in phenotypic drug discovery
High quality chemical probes and chemistry-based target deconvolution techniques will be crucial to the advancement of phenotypic drug discovery, providing new hope for treatment of diseases with highly complex biology.
The tridecaptins: non-ribosomal peptides that selectively target Gram-negative bacteria
Tridecaptins are a re-emerging class of non-ribosomal antibacterial peptides (NRAPs) with potent activity against highly problematic strains of Gram-negative bacteria.
Targeting the SARS-CoV-2-spike protein: from antibodies to miniproteins and peptides
Fighting COVID-19 with high affinity reagents: this review article summarizes the discovery of several classes of (bio) molecules targeting the SARS-CoV-2 spike protein.
Identification of ligand linkage vectors for the development of p300/CBP degraders
To develop new degrader molecules from an existing protein ligand a linkage vector must be identified and then joined with a suitable E3 ligase without disrupting binding to the respective targets.
Structure–activity relationships of valine, tert-leucine, and phenylalanine amino acid-derived synthetic cannabinoid receptor agonists related to ADB-BUTINACA, APP-BUTINACA, and ADB-P7AICA
Synthetic cannabinoid receptor agonists (SCRAs) remain one the most prevalent classes of new psychoactive substances (NPS) worldwide, and examples are generally poorly characterised at the time of first detection.
Photochemical synthesis of an epigenetic focused tetrahydroquinoline library
This work describes the photochemical synthesis of a tetrahydroquinoline library enriched with chemotypes privileged for epigenetic targets and exploring new regions of chemical space.
Analysis of physicochemical properties of protein–protein interaction modulators suggests stronger alignment with the “rule of five”
The physicochemical properties of protein–protein interaction (PPI) modulators vary between those on the market, those in clinical trials, and those in the early drug discovery pipeline.
Replacement of oxygen with sulfur on the furanose ring of cyclic dinucleotides enhances the immunostimulatory effect via STING activation
Cyclic dinucleotide analogues that have sulfur atoms on the furanose rings act as potent and stable STING agonists.
Synthesis and evaluation of pyridine-derived bedaquiline analogues containing modifications at the A-ring subunit
Unique synthetic strategies were developed access to new bedaquiline analogues, leading to the discovery that anti-tubercular activity could be retained following replacement of bedaquiline's quinoline A-ring subunit with pyridine heterocycles.
Drugging the undruggable: a computational chemist's view of KRASG12C
Starting from a literature KRASG12C inhibitor, in this article we show how computational chemistry can help guide the process to a highly optimised tetracyclic series which demonstrates strong tumour regression.
Potent and selective A3 adenosine receptor antagonists bearing aminoesters as heterobifunctional moieties
Potent A3 adenosine receptor antagonists were developed to be conjugated and obtain receptor probes, drug delivery systems, and multitarget or bitopic ligands.
Systematic analysis of the interactions driving small molecule–RNA recognition
This study underscores privileged interactions for RNA binding small molecules, an emerging focus in drug discovery.
About this collection
This collection highlights the excellent work carried out by upcoming members and tomorrow’s leaders in the field of the medicinal chemistry research community.
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