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Themed collection organ-on-a-chip systems: translating concept into practice

27 items
Editorial

Organ-on-a-chip systems: translating concept into practice

Thought leader Michael Shuler provides an update on the Lab on a Chip thematic collection organ-on-a-chip systems: translating concept into practice.

Graphical abstract: Organ-on-a-chip systems: translating concept into practice
Perspective

Introduction to a manuscript series on the characterization and use of microphysiological systems (MPS) in pharmaceutical safety and ADME applications

Opportunities in the drug discovery/development process for potential MPS incorporation.

Graphical abstract: Introduction to a manuscript series on the characterization and use of microphysiological systems (MPS) in pharmaceutical safety and ADME applications
Tutorial Review

Cardiovascular microphysiological systems (CVMPS) for safety studies – a pharma perspective

The integrative responses of the cardiovascular (CV) system are essential for maintaining blood flow to provide oxygenation, nutrients, and waste removal for the entire body.

Graphical abstract: Cardiovascular microphysiological systems (CVMPS) for safety studies – a pharma perspective
Tutorial Review

Application of microphysiological systems in biopharmaceutical research and development

In this review, we describe some of the advances made for tissue-specific microphysiological systems and outline the advantages and challenges of applying and further developing MPS technology in preclinical biopharmaceutical research.

Graphical abstract: Application of microphysiological systems in biopharmaceutical research and development
Tutorial Review

Microphysiological systems for ADME-related applications: current status and recommendations for system development and characterization

Potential applications of MPS in the ADME discipline.

Graphical abstract: Microphysiological systems for ADME-related applications: current status and recommendations for system development and characterization
Tutorial Review

Drug-induced skin toxicity: gaps in preclinical testing cascade as opportunities for complex in vitro models and assays

Selected skin MPS features desired to advance further adoption within the pharmaceutical industry.

Graphical abstract: Drug-induced skin toxicity: gaps in preclinical testing cascade as opportunities for complex in vitro models and assays
Tutorial Review

Microphysiological lung models to evaluate the safety of new pharmaceutical modalities: a biopharmaceutical perspective

Drug developers seek specific advancements in the development and qualification of microphysiological lung models for the evaluation of drug safety; here these essential elements are discussed from the perspective of the biopharmaceutical industry.

Graphical abstract: Microphysiological lung models to evaluate the safety of new pharmaceutical modalities: a biopharmaceutical perspective
Open Access Critical Review

Developing in vitro assays to transform gastrointestinal safety assessment: potential for microphysiological systems

Drug-induced gastrointestinal toxicities (DI-GITs) are among the most common adverse events in clinical trials.

Graphical abstract: Developing in vitro assays to transform gastrointestinal safety assessment: potential for microphysiological systems
Critical Review

A pharmaceutical industry perspective on microphysiological kidney systems for evaluation of safety for new therapies

The human kidney contains approximately one million nephrons.

Graphical abstract: A pharmaceutical industry perspective on microphysiological kidney systems for evaluation of safety for new therapies
Critical Review

Liver microphysiological systems development guidelines for safety risk assessment in the pharmaceutical industry

This pharmaceutical industry guidance based on a 3-staged benchmarking strategy aims to help MPS developers and end users identify what could be the most valuable models for safety risk assessment, as well as provide an overview of contexts of use.

Graphical abstract: Liver microphysiological systems development guidelines for safety risk assessment in the pharmaceutical industry
Open Access Paper

An in vitro vascularized micro-tumor model of human colorectal cancer recapitulates in vivo responses to standard-of-care therapy

VMTs recapitulate in vivo drug responses and also reconstitute the cellular diversity of tumors.

Graphical abstract: An in vitro vascularized micro-tumor model of human colorectal cancer recapitulates in vivo responses to standard-of-care therapy
Paper

A microphysiological early metastatic niche on a chip reveals how heterotypic cell interactions and inhibition of integrin subunit β3 impact breast cancer cell extravasation

Our microfluidic model of early metastatic niche reproduced the extravasation of breast cancer cells in presence of immune blood cells and allowed us to test the effect of an already approved inhibitor of integrin β3 on cancer cell extravasation.

Graphical abstract: A microphysiological early metastatic niche on a chip reveals how heterotypic cell interactions and inhibition of integrin subunit β3 impact breast cancer cell extravasation
Open Access Paper

Organotypic primary blood vessel models of clear cell renal cell carcinoma for single-patient clinical trials

Identification and testing of personalized anti-angiogenic treatments for clear cell renal cell carcinoma using patient-derived microfluidic models of normal and tumor-associated blood vessels.

Graphical abstract: Organotypic primary blood vessel models of clear cell renal cell carcinoma for single-patient clinical trials
Paper

Integrated human organ-on-a-chip model for predictive studies of anti-tumor drug efficacy and cardiac safety

In a novel, integrated platform, integration of human bone tumor and cardiac tissues improved predictive accuracy of linsitinib efficacy and safety. This platform mimicked clinical trial results, unlike other pre-clinical models.

Graphical abstract: Integrated human organ-on-a-chip model for predictive studies of anti-tumor drug efficacy and cardiac safety
Open Access Paper

Multiplexed blood–brain barrier organ-on-chip

The developed multiplexed chip contains 8 channels that can be accessed individually or simultaneously with increased throughput. The visual inspection of cells in the device was improved with our fabricated 2 μm-thick porous PDMS membrane.

Graphical abstract: Multiplexed blood–brain barrier organ-on-chip
Open Access Paper

HepaChip-MP – a twenty-four chamber microplate for a continuously perfused liver coculture model

HepaChip-MP: a 24-culture-chamber, automated microfluidic in vitro model of the liver sinusoid in multiwellplate format.

Graphical abstract: HepaChip-MP – a twenty-four chamber microplate for a continuously perfused liver coculture model
Paper

An integrated biomimetic array chip for high-throughput co-culture of liver and tumor microtissues for advanced anticancer bioactivity screening

An integrated biomimetic array chip (iBAC) enables co-culture of three-dimensional (3D) liver and tumor microtissues for anticancer bioactivity screening at throughputs.

Graphical abstract: An integrated biomimetic array chip for high-throughput co-culture of liver and tumor microtissues for advanced anticancer bioactivity screening
Paper

Matrix density drives 3D organotypic lymphatic vessel activation in a microfluidic model of the breast tumor microenvironment

Lymphatic organotypic in vitro model allows the examination of components of the tumor microenvironment (e.g., ECM density, cancer cells) in lymphatic vessel biology in the context of cancer, providing insights into potential therapeutic targets.

Graphical abstract: Matrix density drives 3D organotypic lymphatic vessel activation in a microfluidic model of the breast tumor microenvironment
Open Access Paper

Applications of the microphysiology systems database for experimental ADME-Tox and disease models

The Microphysiology Systems Database (MPS) is a critical tool for the design, management, analysis, and sharing of MPS study data.

Graphical abstract: Applications of the microphysiology systems database for experimental ADME-Tox and disease models
Open Access Paper

Monitoring tissue-level remodelling during inflammatory arthritis using a three-dimensional synovium-on-a-chip with non-invasive light scattering biosensing

We demonstrate that the integration of complex human synovial organ cultures in a lab-on-a-chip provides reproducible and reliable information on how systemic stress factors affect synovial tissue architectures using light scatter biosensing.

Graphical abstract: Monitoring tissue-level remodelling during inflammatory arthritis using a three-dimensional synovium-on-a-chip with non-invasive light scattering biosensing
Open Access Paper

Low-cost microphysiological systems: feasibility study of a tape-based barrier-on-chip for small intestine modeling

High costs are a key challenge in “democratization” of organ-chip research. We present a low-resource barrier-on-chip based on tape, and use it to model small intestine and its response to chili peppers (capsaicinoids).

Graphical abstract: Low-cost microphysiological systems: feasibility study of a tape-based barrier-on-chip for small intestine modeling
Paper

Microphysiological heart–liver body-on-a-chip system with a skin mimic for evaluating topical drug delivery

Body-on-a-chip in vitro systems are a promising technology that aims to increase the predictive power of drug efficacy and toxicity in humans when compared to traditional animal models.

Graphical abstract: Microphysiological heart–liver body-on-a-chip system with a skin mimic for evaluating topical drug delivery
Paper

Kinetic analysis of sequential metabolism of triazolam and its extrapolation to humans using an entero-hepatic two-organ microphysiological system

We have constructed a mechanism-based pharmacokinetic model for triazolam and its metabolites in the entero-hepatic two-organ MPS, and extrapolated the kinetic information obtained with the MPS to the plasma concentration profiles in humans.

Graphical abstract: Kinetic analysis of sequential metabolism of triazolam and its extrapolation to humans using an entero-hepatic two-organ microphysiological system
Paper

Exosome-mediated microRNA-497 delivery for anti-cancer therapy in a microfluidic 3D lung cancer model

A 3D cell culture system that mimics the lung cancer microenvironment was used to investigate the effect of exosomes encapsulating miR-497 on tumor growth and angiogenesis, and could be a predictive, cost-efficient translational tool to develop targeted cancer therapy.

Graphical abstract: Exosome-mediated microRNA-497 delivery for anti-cancer therapy in a microfluidic 3D lung cancer model
Paper

Organ-on-chips made of blood: endothelial progenitor cells from blood reconstitute vascular thromboinflammation in vessel-chips

Organ-on-chips made of blood: personalized medicine with microfluidics.

Graphical abstract: Organ-on-chips made of blood: endothelial progenitor cells from blood reconstitute vascular thromboinflammation in vessel-chips
Paper

Self-aligning Tetris-Like (TILE) modular microfluidic platform for mimicking multi-organ interactions

Modular multi-organ perfusion systems offer the unique opportunity to customize different physiological systemic interactions.

Graphical abstract: Self-aligning Tetris-Like (TILE) modular microfluidic platform for mimicking multi-organ interactions
Paper

Microfluidic assay for the on-chip electrochemical measurement of cell monolayer permeability

An electrochemical permeability assay that enables the on-chip measurement of endothelial permeability with significant advantages over traditional fluorescent tracer-based assays.

Graphical abstract: Microfluidic assay for the on-chip electrochemical measurement of cell monolayer permeability
27 items

About this collection

A collection of papers and reviews on organ-on-a-chip research focussing on moving from “proof-of-principle” devices to systems that can be routinely incorporated into testing of drugs, cosmetics, food ingredients, and chemicals would be valuable to the development of the field of microphysiological systems.

This on-going collection is collated by Thought leader Michael Shuler and the Lab on a Chip Editorial Board. More details about the collection can be found at https://rsc.li/blog-organ-translation.

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