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Issue 4, 2020
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Application of microphysiological systems in biopharmaceutical research and development

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Abstract

Within the last 10 years, several tissue microphysiological systems (MPS) have been developed and characterized for retention of morphologic characteristics and specific gene/protein expression profiles from their natural in vivo state. Once developed, their utility is typically further tested by comparing responses to known toxic small-molecule pharmaceuticals in efforts to develop strategies for further toxicity testing of compounds under development. More recently, application of this technology in biopharmaceutical (large molecules) development is beginning to be more appreciated. In this review, we describe some of the advances made for tissue-specific MPS and outline the advantages and challenges of applying and further developing MPS technology in preclinical biopharmaceutical research.

Graphical abstract: Application of microphysiological systems in biopharmaceutical research and development

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Article information


Submitted
26 Sep 2019
Accepted
20 Dec 2019
First published
22 Jan 2020

Lab Chip, 2020,20, 697-708
Article type
Tutorial Review

Application of microphysiological systems in biopharmaceutical research and development

N. C. Peterson, P. K. Mahalingaiah, A. Fullerton and M. Di Piazza, Lab Chip, 2020, 20, 697
DOI: 10.1039/C9LC00962K

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