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Themed collection Biological Insights from Synthetic Biology

20 items
Cover

Front cover

Graphical abstract: Front cover
From the themed collection: Biological Insights from Synthetic Biology
Editorial

Biological Insights from Synthetic Biology

Guest editors Jordi Garcia-Ojalvo, Ahmad S. Khalil and John McCarthy introduce the Biological Insights from Synthetic Biology themed issue of Integrative Biology.

Graphical abstract: Biological Insights from Synthetic Biology
From the themed collection: Biological Insights from Synthetic Biology
Review Article

CRISPR-Cas9 technology: applications in genome engineering, development of sequence-specific antimicrobials, and future prospects

The development of CRISPR-Cas9 technology has revolutionized our ability to edit DNA and to modulate expression levels of genes of interest, thus providing powerful tools to accelerate the precise engineering of a wide range of organisms.

Graphical abstract: CRISPR-Cas9 technology: applications in genome engineering, development of sequence-specific antimicrobials, and future prospects
From the themed collection: Integrative Biology Recent Review Articles
Review Article

Synthetic biology approaches in cancer immunotherapy, genetic network engineering, and genome editing

Investigations into cells and their contents have provided evolving insight into the emergence of complex biological behaviors.

Graphical abstract: Synthetic biology approaches in cancer immunotherapy, genetic network engineering, and genome editing
From the themed collection: Biological Insights from Synthetic Biology
Review Article

A morphospace for synthetic organs and organoids: the possible and the actual

Guiding synthetic organ exploration through acknowledging self-organisation and evolutionary constraints in the morphospace of the possible and the actual.

Graphical abstract: A morphospace for synthetic organs and organoids: the possible and the actual
From the themed collection: Biological Insights from Synthetic Biology
Review Article

Synthetic biology: insights into biological computation

Synthetic biology attempts to rationally engineer biological systems in order to perform desired functions. Our increasing understanding of biological systems guides this rational design, while the huge background in electronics for building circuits defines the methodology.

Graphical abstract: Synthetic biology: insights into biological computation
From the themed collection: Biological Insights from Synthetic Biology
Review Article

Using synthetic biology to make cells tomorrow's test tubes

We present various exciting examples of synthetic biology as a means to distill biological systems to their essential features in order to make them theoretically tractable.

Graphical abstract: Using synthetic biology to make cells tomorrow's test tubes
From the themed collection: Biological Insights from Synthetic Biology
Open Access Review Article

The appeasement of Doug: a synthetic approach to enhancer biology

In this review, we discuss how we can use synthetic approaches to study animal enhancers, as well as the importance of both positive and negative results for advancing the field of developmental gene regulation.

Graphical abstract: The appeasement of Doug: a synthetic approach to enhancer biology
From the themed collection: Recent Open Access Articles
Open Access Review Article

Genetically modified bacteriophages

Applications of genetically modified bacteriophages.

Graphical abstract: Genetically modified bacteriophages
From the themed collection: Biological Insights from Synthetic Biology
Review Article

From noise to synthetic nucleoli: can synthetic biology achieve new insights?

Synthetic biology builds new systems not only for applications but also to understand biology, achieving fundamental insights in the process.

Graphical abstract: From noise to synthetic nucleoli: can synthetic biology achieve new insights?
From the themed collection: Biological Insights from Synthetic Biology
Review Article

Synthetic biology: applying biological circuits beyond novel therapies

Synthetic biology, an engineering, circuit-driven approach to biology, has developed whole new classes of tools that can be used together to create novel mock systems, fine-tuned in vivo reporters, spatially and temporally inducible models and closed-loop systems often leading to previously unattainable biological insights.

Graphical abstract: Synthetic biology: applying biological circuits beyond novel therapies
From the themed collection: Biological Insights from Synthetic Biology
Review Article

Addressing biological uncertainties in engineering gene circuits

We discuss biological uncertainties that complicate predictable engineering of gene circuits and potential strategies to address these uncertainties.

Graphical abstract: Addressing biological uncertainties in engineering gene circuits
From the themed collection: Biological Insights from Synthetic Biology
Review Article

Build to understand: synthetic approaches to biology

In this review we discuss how synthetic biology facilitates the task of investigating genetic circuits that are observed in naturally occurring biological systems.

Graphical abstract: Build to understand: synthetic approaches to biology
From the themed collection: Biological Insights from Synthetic Biology
Open Access Review Article

Nature versus design: synthetic biology or how to build a biological non-machine

We suggest that progress in synthetic biology will be achieved by abandoning the bio-machine paradigm and by using an alliance between engineering and evolution as a guiding tool.

Graphical abstract: Nature versus design: synthetic biology or how to build a biological non-machine
From the themed collection: Recent Open Access Articles
Paper

Rationally rewiring the connectivity of the XylR/Pu regulatory node of the m-xylene degradation pathway in Pseudomonas putida

Rational rewiring of the components of the sigma-54 dependent promoter Pu enables transcriptional output to reach its physiological limit.

Graphical abstract: Rationally rewiring the connectivity of the XylR/Pu regulatory node of the m-xylene degradation pathway in Pseudomonas putida
From the themed collection: Biological Insights from Synthetic Biology
Paper

Performing selections under dynamic conditions for synthetic biology applications

As the design of synthetic circuits and metabolic networks becomes more complex it is often difficult to know a priori which parameters and design choices will result in a desired phenotype.

Graphical abstract: Performing selections under dynamic conditions for synthetic biology applications
From the themed collection: Biological Insights from Synthetic Biology
Open Access Paper

Chemical communication between bacteria and cell-free gene expression systems within linear chains of emulsion droplets

Using 1D arrangements of microdroplets to exchange chemical messages between cell-free systems and bacteria.

Graphical abstract: Chemical communication between bacteria and cell-free gene expression systems within linear chains of emulsion droplets
From the themed collection: Recent Open Access Articles
Paper

A synthetic gene circuit for measuring autoregulatory feedback control

A synthetic gene circuit for quantifying the strength of native feedback regulation among the RNA binding proteins in yeast.

Graphical abstract: A synthetic gene circuit for measuring autoregulatory feedback control
From the themed collection: Biological Insights from Synthetic Biology
Paper

Mutual regulation causes co-entrainment between a synthetic oscillator and the bacterial cell cycle

Bidirectional coupling between a synthetic oscillator and the bacterial cell cycle leads to their mutual entrainment.

Graphical abstract: Mutual regulation causes co-entrainment between a synthetic oscillator and the bacterial cell cycle
From the themed collection: Biological Insights from Synthetic Biology
Paper

A second-generation expression system for tyrosine-sulfated proteins and its application in crop protection

The synthetic biological production of posttranslationally modified proteins enables control of biological processes in plants and animals.

Graphical abstract: A second-generation expression system for tyrosine-sulfated proteins and its application in crop protection
From the themed collection: Biological Insights from Synthetic Biology
20 items

About this collection

Synthetic Biology is increasingly used to implement novel applications in which designer organisms perform complex tasks not easily amenable to traditional engineering methods, such as cancer detection, fuel generation, drug production, and recently even the re-creation of extinct species. From a more fundamental perspective, synthetic biology can also be used to probe the limits and capabilities of cells. This issue, guest edited by John McCarthy, Jordi Garcia-Ojalvo and Ahmad Khalil, publishes emerging research using synthetic biology to achieve new biological insights.

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