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Themed collection Probes for in vitro and in vivo fluorescence imaging

26 items
Review Article

Carbon-based hybrid nanogels: a synergistic nanoplatform for combined biosensing, bioimaging, and responsive drug delivery

This review summarizes the latest developments and addresses current applications and future perspectives of carbon-based hybrid nanogels in the biomedical field.

Graphical abstract: Carbon-based hybrid nanogels: a synergistic nanoplatform for combined biosensing, bioimaging, and responsive drug delivery
Review Article

Peptide-based nanoprobes for molecular imaging and disease diagnostics

Peptide-based nanoprobes can improve the diagnosis, staging, treatment, management, and prognosis of numerous diseases by interfacing with and/or sensing of disease-relevant biomolecules.

Graphical abstract: Peptide-based nanoprobes for molecular imaging and disease diagnostics
From the themed collection: Peptide and protein nanotechnology
Review Article

Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications

Peptide– and protein–nanoparticle conjugates have emerged as powerful tools for biomedical applications, enabling the treatment, diagnosis, and prevention of disease.

Graphical abstract: Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications
From the themed collection: Peptide and protein nanotechnology
Review Article

Ratiometric optical nanoprobes enable accurate molecular detection and imaging

Conventional optical nanoprobes rely on absolute intensity-dependent signal readout, which can often cause erroneous sensing and imaging results owing to the existence of analyte-independent confounding factors. Ratiometric signal processing provides built-in self-calibration for signal correction, enabling more accurate molecular detection and imaging.

Graphical abstract: Ratiometric optical nanoprobes enable accurate molecular detection and imaging
Review Article

Optical nano-biosensing interface via nucleic acid amplification strategy: construction and application

This article reviews recent smart constructions and applications of optical nano-biosensing interfaces assisted by a nucleic acid amplification strategy.

Graphical abstract: Optical nano-biosensing interface via nucleic acid amplification strategy: construction and application
Review Article

Engineering functional inorganic–organic hybrid systems: advances in siRNA therapeutics

Engineering functional inorganic–organic hybrid vectors for siRNA delivery systems as a promising approach to overcome many physiological and biological obstacles, which greatly paves the way for a successful, safe and efficient platform in clinical applications.

Graphical abstract: Engineering functional inorganic–organic hybrid systems: advances in siRNA therapeutics
Review Article

Designed transition metal catalysts for intracellular organic synthesis

A review of progress, challenges, and future prospects in developing transition metal catalysts for intracellular organic synthesis.

Graphical abstract: Designed transition metal catalysts for intracellular organic synthesis
Review Article

Far-red fluorescent probes for canonical and non-canonical nucleic acid structures: current progress and future implications

Our review presents the recent progress on far-red fluorescent probes of canonical and non-canonical nucleic acid (NA) structures, critically discusses the design principles, applications, limitations and outline the future prospects of developing newer probes with target-specificity for different NA structures.

Graphical abstract: Far-red fluorescent probes for canonical and non-canonical nucleic acid structures: current progress and future implications
Review Article

Calcium-based biomaterials for diagnosis, treatment, and theranostics

Calcium-based biomaterials with good biosafety and bio-absorbability are promising for biomedical applications such as diagnosis, treatment, and theranostics.

Graphical abstract: Calcium-based biomaterials for diagnosis, treatment, and theranostics
Review Article

Fluorescent probes for the simultaneous detection of multiple analytes in biology

This review identifies and discusses fluorescent sensors that are capable of simultaneously reporting on the presence of two analytes for biological application.

Graphical abstract: Fluorescent probes for the simultaneous detection of multiple analytes in biology
Review Article

The development of ruthenium(II) polypyridyl complexes and conjugates for in vitro cellular and in vivo applications

A detailed overview of the development of Ru(II) polypyridyl complexes as diagnostic and therapeutic agents in vitro and in vivo.

Graphical abstract: The development of ruthenium(ii) polypyridyl complexes and conjugates for in vitro cellular and in vivo applications
Review Article

Chemistry and engineering of cyclodextrins for molecular imaging

Cyclodextrins (CDs) are naturally occurring cyclic oligosaccharides that show favourable properties for probe design and development.

Graphical abstract: Chemistry and engineering of cyclodextrins for molecular imaging
Review Article

Hybridization chain reaction: a versatile molecular tool for biosensing, bioimaging, and biomedicine

This review provides a comprehensive overview of the fundamental principles, analysis techniques, and application fields of hybridization chain reaction and its development status.

Graphical abstract: Hybridization chain reaction: a versatile molecular tool for biosensing, bioimaging, and biomedicine
Review Article

Recent progress in surface-enhanced Raman spectroscopy for biological and biomedical applications: from cells to clinics

In this tutorial review, we summarize the recent progress in SERS-based biological and biomedical applications – from cells to clinics.

Graphical abstract: Recent progress in surface-enhanced Raman spectroscopy for biological and biomedical applications: from cells to clinics
Tutorial Review

Development of endogenous enzyme-responsive nanomaterials for theranostics

This review summarizes the recent progress of endogenous enzyme-responsive nanomaterials based on different building blocks such as polymers, liposomes, small organic molecules, or inorganic/organic hybrid materials for theranostics.

Graphical abstract: Development of endogenous enzyme-responsive nanomaterials for theranostics
Tutorial Review

Crucial breakthrough of second near-infrared biological window fluorophores: design and synthesis toward multimodal imaging and theranostics

Recent advances in the chemical design and synthesis of fluorophores in the second near-infrared biological window (NIR-II) for multimodal imaging and theranostics are summarized and highlighted in this review article.

Graphical abstract: Crucial breakthrough of second near-infrared biological window fluorophores: design and synthesis toward multimodal imaging and theranostics
Open Access Tutorial Review

A guide to integrating immunohistochemistry and chemical imaging

A ‘how-to’ guide for designing chemical imaging experiments using antibodies and immunohistochemistry.

Graphical abstract: A guide to integrating immunohistochemistry and chemical imaging
Tutorial Review

Shedding light on tau protein aggregation: the progress in developing highly selective fluorophores

The development of highly selective fluorophores for tau protein aggregates, a key feature of Alzheimer's disease, is highlighted.

Graphical abstract: Shedding light on tau protein aggregation: the progress in developing highly selective fluorophores
Tutorial Review

Quinone-based fluorophores for imaging biological processes

This tutorial review covers recent advances in the design, synthesis and application of quinone-based fluorescent agents for visualizing specific processes in multiple biological systems, from cells to tissues and complex organisms in vivo.

Graphical abstract: Quinone-based fluorophores for imaging biological processes
Tutorial Review

Fluorogenic reaction-based prodrug conjugates as targeted cancer theranostics

This Tutorial Review will describe various fluorogenic reaction-based prodrug strategies used for targeted theranostic drug delivery.

Graphical abstract: Fluorogenic reaction-based prodrug conjugates as targeted cancer theranostics
Open Access Tutorial Review

Fluorescent chemosensors: the past, present and future

Fluorescent chemosensors for ions and neutral analytes have been widely applied in many diverse fields such as biology, physiology, pharmacology, and environmental sciences.

Graphical abstract: Fluorescent chemosensors: the past, present and future
Open Access Tutorial Review

Multiplexed photoluminescent sensors: towards improved disease diagnostics

This tutorial review highlights the development of multiplexed photoluminescent sensors which can simultaneously detect multiple and diverse biomarkers that exist in a homogenous solution or a single cell, accelerating the progress towards precise disease diagnostics.

Graphical abstract: Multiplexed photoluminescent sensors: towards improved disease diagnostics
Tutorial Review

Advancing porphyrin's biomedical utility via supramolecular chemistry

Enhancing existing porphyrin functionality and introducing new capabilities via supramolecular chemistry.

Graphical abstract: Advancing porphyrin's biomedical utility via supramolecular chemistry
Tutorial Review

Supramolecular catalysis and dynamic assemblies for medicine

This review provides new insights into supramolecular catalysis and dynamic regulation of molecular assemblies for biomedical applications.

Graphical abstract: Supramolecular catalysis and dynamic assemblies for medicine
Tutorial Review

Motion-induced change in emission (MICE) for developing fluorescent probes

A new concept of motion-induced change in emission (MICE) in a single molecule for developing fluorescent probes is presented and summarized.

Graphical abstract: Motion-induced change in emission (MICE) for developing fluorescent probes
Tutorial Review

Methods for the detection and identification of pathogenic bacteria: past, present, and future

In this tutorial review, the techniques involved in the detection of pathogenic bacteria are described.

Graphical abstract: Methods for the detection and identification of pathogenic bacteria: past, present, and future
26 items

About this collection

We are delighted to present a Chemical Society Reviews themed collection on probes for in vitro and in vivo fluorescence imaging. This collection brings together reviews from leading experts and details recent advances in this field, including fluorescence- and peptide-based nanoprobes, surface-enhanced Raman spectroscopy, molecular imaging and theranostics. We hope you enjoy reading these Reviews!

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