Themed collection 2023 Pioneering Investigators
Contributors to the Pioneering Investigators collection 2023: Part 1
This profile article showcases researchers who have contributed an article to the 2023 Pioneering Investigators collection.
MFM-300(Sc): a chemically stable Sc(III)-based MOF material for multiple applications
A summary of the applications of MFM-300(Sc), as well as some emerging advanced applications, have been discussed.
Emerging 2D pnictogens: a novel multifunctional photonic nanoplatform for cutting-edge precision treatment
2D pnictogens and their cutting-edge precision treatment applications.
Recent advances in direct seawater splitting for producing hydrogen
The recent progress in designing efficient direct seawater electrolysis systems is discussed in detail, including catalyst design, electrolyser assembly, membrane regulation, and electrolyte engineering.
One reaction – double stereoinduction: C–H activation as a privileged route towards complex atropisomeric molecules
Expanding the importance of chirality and implementation of stereogenic information within complex molecular design has recently reached a new level: design of innovative enantiopure scaffolds bearing multiple chiral elements.
Transition metal-catalysis in interrupted borrowing hydrogen strategy
This review article highlights the recent advances of transition-metal-catalyzed interrupted borrowing hydrogen (IBH) catalysis and its applications in the sustainable and affordable chemical synthesis using alcohols as C1 feedstocks.
Fluorescence labeling of extracellular vesicles for diverse bio-applications in vitro and in vivo
We provide comprehensive highlights of the state-of-the-art studies on fluorescent labelling of EVs, covering the various labelling strategies, the biomedical application in vitro, and the study on EV biology in vivo based on bioimaging tools.
DNA-encoded libraries via late-stage functionalization strategies: a review
The hit finding strategy in drug discovery has undergone a tremendous change in the past decade with the advent of DNA-encoded libraries with diverse chemical libraries.
Structural authentication of intermediates of mechanistic significance in palladium- and nickel-catalysed cross-couplings: case studies
This Highlight examines key strategies that have enabled the structural authentication of important species that shed light on fundamental on-cycle intermediates in transition-metal-catalysed cross-couplings.
Site-selective and stereoselective transformations on p-quinols & p-quinamines
Prochiral 2,5-cyclohexadienones, being stable and easily accessible, are privileged key building blocks for the synthesis of complex molecules and bioactive natural products.
Organic thermoelectric generators: working principles, materials, and fabrication techniques
Organic thermoelectric generators are devices based on organic (semi)conductors that allow to recycle waste heat by partially converting it to electrical power.
Self-assembling materials functionalizing bio-interfaces of phospholipid membranes and extracellular matrices
This article highlights the development of bioinspired supramolecular materials, i.e., synthetic extracellular matrices and membrane-deforming materials, mimicking the contact events seen at bio-interfaces for applications in injured brain regeneration and in vivo delivery.
Emerging conjugated polymers for heterogeneous photocatalytic chemical transformation
Design strategies for efficient π-conjugated polymer-based photocatalysts, and the progress achieved in light-driven chemical transformations using them.
Iminium and azonium-activated metal and oxidant-free C–H functionalization of aliphatic amines
Iminium or azonium ions formed via classical condensation of amines with carbonyls or nitrosoarenes mediate C–H functionalizations of aliphatic amines under metal and oxidant free conditions.
Visible light-mediated photolysis of organic molecules: the case study of diazo compounds
This article discusses the photochemistry of several diazo compounds undergoing visible light-mediated photolysis to generate free carbenes (or other highly reactive intermediates), which can be sequentially trapped by different reacting partners.
Organelle-targeted gene delivery in plants by nanomaterials
This feature article highlights the latest developments and our strategies in organelle-specific nanomaterial delivery within plants.
Biogenetic space-guided synthesis of rearranged terpenoids
Biogenetic space-guided synthesis is a tool to design efficient chemical syntheses of complex terpenoids by evaluating their surrounding biogenetic space.
Förster resonance energy transfer involving the triplet state
This feature article outlines the triplet harvesting via Förster resonance energy transfer (FRET) from both the fundamental aspects to emerging applications in optoelectronics and bioimaging.
Three-dimensional graphene/metal–organic framework composites for electrochemical energy storage and conversion
This feature article summarizes the recent research progress in the preparation methods of 3D graphene/MOF composites and their derivatives as well as their applications in the fields of electrochemical energy storage and conversion.
Catalytic conversion of chitin as a nitrogen-containing biomass
The efficient catalytic conversion of chitin enables the material cycle through natural carbon and nitrogen fixation.
Recent advances in zinc–air batteries: self-standing inorganic nanoporous metal films as air cathodes
This review revisits critical descriptors to assess the performance of Zn–air batteries. The recent progress of inorganic nanoporous metal films as self-standing air electrodesfor Zn–air batteries is systematically summarized and analyzed.
Design and bioanalytical applications of stochastic DNA walkers
Synthetic DNA walkers that traverse stochastically on 2D and 3D tracks pave a promising way to design biosensors for diverse analytical applications.
High spatial resolution ambient tip-enhanced (multipolar) Raman scattering
Numerous physical and chemical processes contribute to tip-enhanced Raman spectral nano-images.
Visible-light-induced protein labeling in live cells with aryl azides
This feature article reviews the recent progress of protein labeling in live cells with aryl azides induced by visible-light irradiation.
Optothermal rotation of micro-/nano-objects
Stemming from distinct thermal phenomena, heat-mediated optical rotation of tiny objects is stimulating advances in a wide range of fields, including single-cell mechanics, 3D bio-imaging, and micro/nanomotors.
NMR methods for the analysis of mixtures
NMR spectroscopy is a powerful approach for the analysis of mixtures. This feature article describes a selection of methods that aim to address the complexity, the low concentrations, and the changing nature that mixtures can display.
Selective access to dihydrophenanthridines and phenanthridinones via cyclisation of aryl amines onto N-tethered arynes
Cyclisation of aryl amines onto tethered arynes affords selective access to phenanthridine derivatives via simple switch of reaction environment.
Highly chemoselective homologative assembly of the α-substituted methylsulfinamide motif from N-sulfinylamines
α-Substituted methylsulfinamide are prepared through the homologation of electrophilic N-sulfinylamines with Li-CHXY reagents.
Localised polymerisation of acrylamide using single-barrel scanning electrochemical cell microscopy
Single-barrel scanning electrochemical cell microscopy has been used for the first time to achieve localized polymerization of acrylamide at a surface with fine control over the reactions and the resulting polymer features formed.
Selective electrochemical CO2 conversion with a hybrid polyoxometalate
An organofunctionalised hybrid polyoxometalate bearing Ru antennae exhibits selective CO2 electrochemical reduction to C1 feedstocks.
Electrocatalytic hydrogen evolution with a copper porphyrin bearing meso-(o-carborane) substituents
A new Cu porphyrin bearing meso-(o-carborane) substituents is designed and synthesized and displays much higher activity than o-carborane-free analogues for the electrocatalytic hydrogen evolution reaction in both organic and aqueous solutions.
Phospholipid headgroup composition modulates the molecular interactions and antimicrobial effects of sulfobetaine zwitterionic detergents against the “ESKAPE” pathogen Pseudomonas aeruginosa
Using a combination of accessible multinuclear NMR techniques to quantify phospholipid membrane headgroup composition and molecular level mode of action.
Asymmetric alkene–alkene reductive cross-coupling reaction via visible-light photoredox/cobalt dual catalysis
The first example of asymmetric alkene–alkene reductive coupling is demonstrated via visible-light-fueled photoredox/cobalt dual catalysis.
Learning from nature: recovery of rare earth elements by the extremophilic bacterium Methylacidiphilum fumariolicum
We present the extremophilic bacterium Methylacidiphilum fumariolicum SolV as a platform for the selective recovery of rare earth elements (REE).
Quantitative determination of the full switching cycle of photochromic fluorescent proteins
The observation of incomplete on/off switching of rsGreen1 at different pH as well as a different initial first cycle can be quantitatively described by our simple 4-state model presented in this work.
Development of multifunctional ionogels derived from a dynamic deep eutectic solvent
A multifunctional ionogel is developed and explored as a flexible conductor by combining thermally-initiated ring-opening polymerization of a dynamic deep eutectic solvent (DDES) containing α-lipoic acid as well as multiple dynamic interactions.
Calcium-triggered DNA-mediated membrane fusion in synthetic cells
We develop a novel calcium-triggered membrane fusion strategy for synthetic cells by regulating DNA-mediated membrane fusion with membrane-bound polyethylene glycol polymeric chains that are cleavable by the calcium-activated protease calpain-1.
Hybrid plasmonic metasurface as enhanced Raman hot-spots for pesticide detection at ultralow concentrations
A surface-enhanced Raman scattering (SERS) active metasurface composed of metallic nanohole arrays and metallic nanoparticles is developed.
Linear and macrocyclic oligo(p-phenylene iminoboranes) with ferrocenyl side groups – observation of selective, non-templated macrocyclization
Linear and macrocyclic oligo(phenylene iminoboranes) with ferrocenyl side groups have been prepared, selective macrocyclization proceeds without a template.
An ambient pressure, direct hydrogenation of ketones
We report two bifunctional (pyridyl)carbene-iridium(I) complexes that catalyze ketone and aldehyde hydrogenation at ambient pressure.
Modulated self-assembly of three flexible Cr(III) PCPs for SO2 adsorption and detection
Modulated self-assembly protocols are used to develop facile, HF-free syntheses of the archetypal flexible PCP, MIL-53(Cr), and novel isoreticular analogues MIL-53(Cr)-Br and MIL-53(Cr)-NO2, which adsorb and sense SO2.
Zr-MOF membranes with ultra-fast water-selective permeation towards intensification of esterification reaction
Zr-MOF membranes for removing water from organic solvents (ethyl acetate, ethanol, acetic acid) existing in esterification reaction.
On the role of wall thickness in determining the plasmonic properties of silver-gold nanocages
Understanding the roles played by wall thickness in determining the plasmonic properties of Ag–Au nanocages from both experimental and theoretical perspectives.
A molecular aluminium fulleride
Go-Al! low valent aluminium scores a Hat-trick by converting C60 to a tri-substituted molecular aluminium fulleride.
Ring expansion reactions of PO-containing molecules
A series of ring expansion reactions of PO-containing molecules have been developed for the synthesis of medium-sized ring cyclic phosphonate esters and phosphonamidates.
Chemically selective raising and rolling of oil-droplets underwater: an equipment-free chemical sensing method
Simple chemical reactions are rationally introduced to achieve mono- and dual-functionalized multilayer coatings for raising of the oil contact angle and rolling of beaded oil-droplets underwater, only in the presence of targeted toxic chemicals.
Synthesis of complex aryl MIDA boronates by Rh-catalyzed [2+2+2] cycloaddition
A Rh-catalyzed [2+2+2] cycloaddition approach for the synthesis of BMIDA-functionalized arenes is reported.
A tetranuclear magnesium hydride cluster with a four-coordinate hydride in near square-planar geometry
A dimeric magnesium hydride cluster has been synthesized. In the solid state it features a hydride ion that is coordinated to four magnesium ions at the same time in an unusual nearly square-planar fashion.
Self-assembly of benzophenone-diphenylalanine conjugate into a nanostructured photocatalyst
The conjugation of photoactive benzophenone with diphenylalanine yielded a self-assembling photocatalyst that was probed in the E → Z photoisomerisation of stilbene derivatives.
Targeted delivery of alcohol-containing payloads with antibody-drug conjugates
We herein describe the cell-specific release of alcohol-containing payloads via a sulfatase-sensitive linker in antibody-drug conjugates (ADCs).
Peripheral nucleic bases boost H2 production by synthetic molecular catalysts in acidic water
The strategic inclusion of nucleic bases adenine, cytosine, and thymine, in the form of outer coordination sphere, positively impacts the electro- and photocatalytic H2 production by cobaloxime cores.
A N/S co-doped free-standing carbon electrode derived from waste facial masks for anti-freezing flexible quasi-solid-state supercapacitors
A low-cost N/S co-doped carbon cloth is made by pyrolysis recycling of waste facial masks as robust free-standing electrodes for flexible anti-freezing quasi-solid-state supercapacitors with high energy and good low temperature adaptability.
Random copolymerization of trimethylene carbonate with L-lactide initiated by amine-bridged bis(phenolate) neodymium alkoxides
Neodymium complexes were synthesized and employed as efficient initiators for the random copolymerization of TMC and L-LA under mild conditions.
Structural and reactive evolution of oxidatively grafted Pd catalysts on MnO2 for the low-temperature oxidation of CO
Atomically-dispersed Pd species supported on MnO2 synthesized by the chemisorption of Pd(tricyclohexylphosphine)2 catalyze the low temperature (295–323 K) oxidation of CO to CO2.
Enhancing the gastrointestinal stability of salmon calcitonin through peptide stapling
Salmon calcitonin (sCT) is a polypeptide hormone available in the clinic.
Reduction of 2-H-substituted pyrrolinium cations: the carbon–carbon single bond in air stable 2,2′-bipyrrolidines as a two-electron-source
2-Substituted pyrrolinium cations are reduced to air and moisture stable 2,2′-bipyrrolidines − the newly formed carbon–carbon single bond is electron-rich and may be utilized as an organic electron donor for various chemical transformations.
An efficient metal-free desulfurization strategy promoted by Togni-II reagent
Desulfurization is a versatile synthetic tool in organic synthesis, particularly in peptide chemistry, where it offers an effective conversion strategy for compounds that contain mercaptan groups.
NHC-catalyzed [12+2] reaction of polycyclic arylaldehydes for access to indole derivatives
NHC-catalyzed remote activation of C(sp3)–H and asymmetric [12+2] cycloaddition reaction for access to structurally complex bioactive indole derivatives.
NDIPhos as a platform for chiral supramolecular ligands in rhodium-catalyzed enantioselective hydrogenation
A new class of self-assembled bidentate NDI-derived ligands featuring π–π interactions is described, which were successfully used in rhodium-catalyzed enantioselective hydrogenation of diverse olefins.
A hampered oxidative addition of pre-coordinated pincer ligands can favour alternative pathways of activation
Pre-coordination to a transition metal by the terminal donor groups of a tri-dentate ligand is a common way to stabilise elusive groups, to achieve unprecedented bond activation and to develop novel modes of metal–ligand-cooperation for catalysis.
Copper(II) defect-cubane water oxidation electrocatalysts: from molecular tetramers to oxidic nanostructures
We introduce a bio-inspired copper cubane-type water oxidation catalyst, and we track its transformations and electrocatalytically active species with comprehensive in situ and post-catalytic techniques.
Water-soluble terphenarene macrocycle: a versatile reversal agent of neuromuscular blockers
Herein we report the design and synthesis of a terphen[n]arene derivative functionalised with sulfate acid ester groups.
Vacancy effect on the electrocatalytic activity of LaMn1/2Co1/2O3−δ for hydrogen and oxygen evolution reactions
Significant enhancement of electrocatalytic properties is achieved through the incorporation of oxygen-vacancies in a perovskite oxide, while retaining the structure.
Sensitive quantification of short-chain fatty acids combined with global metabolomics in microbiome cultures
A novel chemical metabolomics tool for quantification of short-chain fatty acids in bacterial cultures that is compatible with global metabolomics analysis due to the use of a limited sample volume.
Borenium-ion-catalyzed hydrogenation of arenes
Metal-free hydrogenation of arenes was achieved by using a borenium ion as the catalyst.
A visible light mediated alkyl sulfonylative cascade using Hantzsch esters via SO2 insertion
A highly regio- and diastereoselective, 4-CzIPN catalyzed alkyl sulfonylative cascade of alkynyl tethered cyclohexadienones with Hantzsch esters and DABSO was developed to access functionalized dihydrochromenones.
A diselenide additive enables photocatalytic hydroalkoxylation of gem-difluoroalkenes
A photocatalytic hydroalkoxylation reaction enables the coupling of aliphatic alcohols with gem-difluoroalkenes, expanding the scope of accessible α,α-difluorinated ethers, a desirable substructure for medicinal and agricultural chemists.
Benchmarking of commercial Cu catalysts in CO2 electro-reduction using a gas-diffusion type microfluidic flow electrolyzer
Commercial Cu could deliver a high selectivity of ∼80% for multicarbon products at an industrially relevant rate of 300 mA cm−2.
Seed-mediated synthesis of monodisperse plasmonic magnesium nanoparticles
We demonstrate the seed-mediated synthesis of plasmonic, metallic magnesium nanoparticles, leading to controllable and monodisperse nanoparticle size distributions.
Phenoxazine-based small molecule heterojunction nanoparticles for photocatalytic hydrogen production
Small molecule heterojunction nanoparticles based on a phenoxazine photosensitizer and a non-fullerene acceptor ITIC have been developed for photocatalytic hydrogen production.
About this collection
ChemComm is here to support researchers throughout their careers. To complement our annual Emerging Investigators collection, this special collection showcases high quality research being carried out by international researchers who are more established in their independent careers and have been recognised as making a significant contribution to their field.
New articles will be added to this collection as they are published.