Themed collection 32nd Annual Conference of the European Society for Biomaterials, 2022

This minireview highlights recent advances on the application of embedded 3D bioprinting concepts for the fabrication of in vitro models.

The kidney regeneration strategies by tissue engineering using polymers and hydrogels, creating functional cell material scaffolds. AKD (acute kidney disease), CKD (chronic kidney disease), and ESRD (end-stage renal disease). (Created with BioRender).

A library of low molecular weight biocompatible inks has been developed to be used in DLP printing. The resulting inks present low viscosity and are printable without diluents or solvents, resulting in structures with high shape fidelity.

Fetuin A functionalisation of biodegradable PLLA-co-PEG nonwovens lead to enhanced biomineralisation and improved cell morphology and spreading in vitro.

The supramolecular presentation of bioinstructive peptides on multilayered nanofilms enabled self-assembled nanofibers with high laminin-derived IKVAV epitope density, enhancing neuronal cell adhesion, viability, morphology and neurite outgrowth.

The functionalization of 3D-printed poly-L-lactic acid (PLLA) and poly(L-lactic-co-ε-caprolactone) (PLCL) bioresorbable stents has been successfully achieved with linear RGDS and YIGSR peptides, as well as a dual platform containing both motifs within a single biomolecule.

Se-incorporated MSNs were synthesized by loading SeO₃²⁻, doping SeO₃²⁻, and incorporating SeNP into MSNs. Se-incorporated MSNs showed GSH/NADPH sensitive Se release, selective OS cell inhibition and ROS induction.

The aim of this work was to develop a filtering biocidal polypropylene (PP) nonwoven textile structure to block and inactivate airborne bacteria and viruses.

The possibility of decreasing the dissolution rate of SiN coatings using Fe and C is promising and the released ions were demonstrated to be compatible with microglia viability, in both 2D cultures and 3D collagen hydrogels.

Herein we demonstrate the fabrication and controlled degradation of arrays of polycaprolactone-based micropillars, achieved through the combination of direct laser writing and nanoimprint lithography.

Electrophoretic deposition allows obtaining gentamicin-loaded chitosan–methylcellulose patches (CS–MC/GS) with distinctive mucoadhesive and antibacterial characteristics, useful to treat mouth bacterial infections.

Testing libraries of phenylboronic acid derivatives and diols revealed a new crosslinking couple for the formation of viscoelastic hydrogels with tunable properties and long-term stability.

Our fully biodegradable dendritic nanosystem proved to be biocompatible and mediated fast cellular internalization in neuronal cell lines and cortical neurons, showing great potential as a nucleic acid delivery vector for nervous system applications.

Schematic representation of PDAC-on-chip reassembly the pancreatic acino-ductal unit composed of healthy and pathological human pancreatic ductal epithelial cells (HPDE and KRAS-HPDE, respectively) surrounded by pancreatic stellate cells (PSCs).

Novel PGS-co-PEG elastomers showed multifunctional characteristics such as high swelling, flexibility, bioadhesiveness and biocompatibility, and good biodegradation, mechanical properties and pH-responsive behaviour.