Microfluidics systems with societal impact in Analytical Methods
Guest Editors Michael Roper, Christopher Easley and Fiona Regan, alongside Deputy Editor Maria Southall, introduce the Analytical Methods themed collection on microfluidic systems.
In celebration of the 60th birthday of 2 microfluidics pioneers: Professor Susan Lunte and Professor James Landers
Christopher Easley, Fiona Regan, Michael Roper and R. Scott Martin look at the achievements of Susan Lunte and James Landers.
Microfluidics in coagulation monitoring devices: a mini review
Diagnosis and monitoring of disorders of coagulation and disturbances in haemostasis has been around for many years. The development of POC technologies in this area has rapidly advanced and continues to improve upon the monitoring and diagnosis of these disorders. This review highlights recent and ongoing advances in microfluidics with application to the areas of haemostasis and coagulation biology.
Integrated paper-based microfluidic devices for point-of-care testing
This review highlights the developments, accomplishments and challenges of integrated μPADs, including sample pretreatment, signal transduction/amplification and results output.
Recent advances in an organ-on-a-chip: biomarker analysis and applications
Recent advances in high-throughput biomarker analysis based on an organ-on-a-chip and its applications in drug development.
Flow-gated capillary electrophoresis: a powerful technique for rapid and efficient chemical separation
Flow-gated capillary electrophoresis (CE) is a hybrid of conventional and microchip CE since it employs a fused silica capillary as the separation channel while taking advantage of the well-controlled flow-gated injection, which adds versatility in terms of separation efficiency, analytical throughput, and ease of coupling with sample pretreatment procedures.
Recent advances in toner-based microfluidic devices for bioanalytical applications
Toner-based microfluidic devices have emerged as promising platforms for bioanalytical applications.
A review of centrifugal microfluidics in environmental monitoring
There is currently a gap in the use of centrifugal microfluidics in the field of environmental sensing.
Accurate flow in augmented networks (AFAN): an approach to generating three-dimensional biomimetic microfluidic networks with controlled flow
A network augmentation approach that adds synthetic connections to microvascular networks to induce biomimetic microfluidic flow.
Single board computing system for automated colorimetric analysis on low-cost analytical devices
Colorimetric detection, while a user-friendly and easily implemented method of analysis on low-cost analytical devices, often suffers from subjectivity by the device user.
Rapid fabrication of versatile omni-directional and long-distance three-dimensional flow paper-fluidic analytical devices using a cut-and-insert method for biomedical applications
Paper fluidics has recently offered an approach to precisely guide liquid flow in analytical devices with a low-cost regime.
Droplet microfluidics in thermoplastics: device fabrication, droplet generation, and content manipulation using integrated electric and magnetic fields
Droplet microfluidic devices with integrated operations including droplet generation, electrical injection, and magnetic splitting were manufactured in thermoplastics.
Carbon tape as a convenient electrode material for electrochemical paper-based microfluidic devices (ePADs)
ePADs represent an innovative and versatile platform for fluid handling and analysis.
Photolithographic structuring of soft, extremely foldable and autoclavable hydrophobic barriers in paper
Method for photolithographic structuring of foldable hydrophobic barriers in paper for the creation of microfluidic paper-based analytical devices (μPADs).
Continuous monitoring of adenosine and its metabolites using microdialysis coupled to microchip electrophoresis with amperometric detection
Reversibly sealed all-PDMS device with CF working electrode for continuous on-line analysis of microdialysis samples.
Characterization of low adsorption filter membranes for electrophoresis and electrokinetic sample manipulations in microfluidic paper-based analytical devices
Low adsorption filter membrane materials facilitate effective zonal electrophoresis and electrokinetic gating in microfluidic paper-based analytical devices (μPADs).
Advancement of analytical modes in a multichannel, microfluidic droplet-based sample chopper employing phase-locked detection
Multichannel droplet-based microfluidic sample chopper (μChopper) allows continuous calibration, nanoliter sampling, and protein quantification in human serum.
Use of 3D printing and modular microfluidics to integrate cell culture, injections and electrochemical analysis
Here we show that separate modules fabricated using 3D printing technology can be easily assembled to quantitate the amount of nitric oxide released from endothelial cells following ATP stimulation.
Steroid inhibition of erythrocyte-derived ATP reduces endothelial cell production of nitric oxide in a 3D-printed fluidic model
Multiple sclerosis (MS) is a disease of the central nervous system affecting over 2.5 million people worldwide.
A low-cost integrated biosensing platform based on SiN nanophotonics for biomarker detection in urine
We present a low-cost integrated nanophotonic lab-on-a-chip platform suitable for point-of-care (POC) biomarker analysis.
New paper-based microfluidic tools for the analysis of blood serum protein and creatinine built via aerosolized deposition of polycaprolactone
Aerosolized deposition of a polymer solution to a substrate allows for rapid, low-cost fabrication of 3D microfluidic devices for bioassays.
An all thiol–ene microchip for solid phase extraction featuring an in situ polymerized monolith and integrated 3D replica-molded emitter for direct electrospray mass spectrometry
Pre-concentration and clean-up are essential sample preparation steps in environmental, forensics and bio-analytical assays.
A pilot study in humans of microneedle sensor arrays for continuous glucose monitoring
Although subcutaneously implanted continuous glucose monitoring (CGM) devices have been shown to support diabetes self-management, their uptake remains low due to high costs and poor accuracy and precision arising from their invasiveness.
Label-free mesenchymal stem cell enrichment from bone marrow samples by inertial microfluidics
Isolation of pure populations of mesenchymal stem cells from bone marrow aspirate is a critical need in regenerative medicine such as orthopedic and cartilage reconstruction with important clinical and therapeutic implications.
Enhanced microchip electrophoresis separations combined with electrochemical detection utilizing a capillary embedded in polystyrene
A polystyrene–PDMS device utilizing an embedded fused silica capillary and electrochemical detection was used for improved efficiency separations of catecholamines.
Microfluidic detection with acoustic spectroscopy (MIDAS) for analysis of insulin formulation stability
Ultrasonic spectroscopy is a viable complement to current techniques used to analyze insulin stability due to its simplicity, lack of sample preparation, and non-destructive properties.
Automated 4-sample protein immunoassays using 3D-printed microfluidics
A 3D-printed microfluidic array detects 2 proteins in 4 samples at very low cost with downloadable plans