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Issue 25, 2018
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New paper-based microfluidic tools for the analysis of blood serum protein and creatinine built via aerosolized deposition of polycaprolactone

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Abstract

This article describes a low-cost method for rapid fabrication of paper-based microfluidic devices using an aerosolized polymeric solution and substrates masked with painter's tape. This approach requires only a few simple tools and uses low-cost supplies to achieve fully functional microfluidic paper-based analytical devices. The method is capable of producing devices with minimum hydrophilic channel widths of 482 ± 4 μm, with the channel height being dictated by the substrate thickness. Complete hydrophobic barriers can be achieved with widths of only 257 ± 2 μm. This technique enables two dimensional (2D) fluidic pattern fabrication on a single membrane while complex three dimensional (3D) fluidic pattern fabrication is possible by simply incorporating a stack and lamination step. Devices built using this approach were applied in two clinical diagnostic applications: quantitative colorimetric assays for protein and for creatinine.

Graphical abstract: New paper-based microfluidic tools for the analysis of blood serum protein and creatinine built via aerosolized deposition of polycaprolactone

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Publication details

The article was received on 01 May 2018, accepted on 03 Jun 2018 and first published on 04 Jun 2018


Article type: Paper
DOI: 10.1039/C8AY00981C
Anal. Methods, 2018,10, 2994-3000

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    New paper-based microfluidic tools for the analysis of blood serum protein and creatinine built via aerosolized deposition of polycaprolactone

    C. A. Heist, G. C. Bandara, D. J. Bemis, J. C. Pommerenck and V. T. Remcho, Anal. Methods, 2018, 10, 2994
    DOI: 10.1039/C8AY00981C

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