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Themed collection Innovative Tools for Cancer Screening, Detection and Diagnostics

34 items
Editorial

Cancer: a global concern that demands new detection technologies

Welcome to this Analyst themed issue on Innovative Tools for Cancer Screening, Detection and Diagnostics, guest edited by Steven A. Soper and Avraham Rasooly.

Graphical abstract: Cancer: a global concern that demands new detection technologies
Minireview

Liquid biopsy for detection of actionable oncogenic mutations in human cancers and electric field induced release and measurement liquid biopsy (eLB)

This paper will review the analytical strategies used to assess oncogenic mutations from biofluid samples. Clinical applications will also be discussed.

Graphical abstract: Liquid biopsy for detection of actionable oncogenic mutations in human cancers and electric field induced release and measurement liquid biopsy (eLB)
From the themed collection: Recent Review Articles
Minireview

Aptamers: versatile molecular recognition probes for cancer detection

Aptamers as specific and sensitive probes for in vitro diagnosis of cancer cells, immunohistochemical (IHC) staining of tumor tissues, and in vivo imaging detection of tumors.

Graphical abstract: Aptamers: versatile molecular recognition probes for cancer detection
Minireview

Biosensors and nanobiosensors for therapeutic drug and response monitoring

Review of different biosensors and nanobiosensors increasingly used in therapeutic drug monitoring (TDM) for pharmaceutical drugs with dosage limitations or toxicity issues and for therapeutic response monitoring.

Graphical abstract: Biosensors and nanobiosensors for therapeutic drug and response monitoring
From the themed collection: Recent Review Articles
Minireview

Isolation and enrichment of circulating biomarkers for cancer screening, detection, and diagnostics

A liquid biopsy is more practical for real-time monitoring of disease progression than tissue biopsy.

Graphical abstract: Isolation and enrichment of circulating biomarkers for cancer screening, detection, and diagnostics
From the themed collection: Recent Review Articles
Open Access Minireview

Emerging techniques in the isolation and characterization of extracellular vesicles and their roles in cancer diagnostics and prognostics

We present an overview of current isolation, detection, and characterization methods of extracellular vesicles and their applications and limitations as a potential emerging biomarker in cancer management and their clinical implementation.

Graphical abstract: Emerging techniques in the isolation and characterization of extracellular vesicles and their roles in cancer diagnostics and prognostics
From the themed collection: Recent Review Articles
Minireview

Cancer screening via infrared spectral cytopathology (SCP): results for the upper respiratory and digestive tracts

Instrumental advances in infrared micro-spectroscopy have made possible the observation of individual human cells and even subcellular structures.

Graphical abstract: Cancer screening via infrared spectral cytopathology (SCP): results for the upper respiratory and digestive tracts
From the themed collection: Recent Review Articles
Tutorial Review

Can we observe changes in mRNA “state”? Overview of methods to study mRNA interactions with regulatory proteins relevant in cancer related processes

RNA binding proteins (RBP) regulate the editing, localization, stabilization, translation, and degradation of ribonucleic acids (RNA) through their interactions with specific cis-acting elements within target RNAs.

Graphical abstract: Can we observe changes in mRNA “state”? Overview of methods to study mRNA interactions with regulatory proteins relevant in cancer related processes
From the themed collection: Recent Review Articles
Critical Review

Microfluidics and cancer analysis: cell separation, cell/tissue culture, cell mechanics, and integrated analysis systems

Among the growing number of tools available for cancer studies, microfluidic systems have emerged as a promising analytical tool to elucidate cancer cell and tumor function.

Graphical abstract: Microfluidics and cancer analysis: cell separation, cell/tissue culture, cell mechanics, and integrated analysis systems
From the themed collection: Recent Review Articles
Critical Review

Cancer biomarker discovery using DNA aptamers

Aptamers, as chemical antibodies, show great promise and power for cancer biomarker discovery and biomarker-based clinical applications.

Graphical abstract: Cancer biomarker discovery using DNA aptamers
From the themed collection: Recent Review Articles
Critical Review

Raman technologies in cancer diagnostics

This review explores Raman technologies with a particular emphasis on their utility for cancer diagnostic applications.

Graphical abstract: Raman technologies in cancer diagnostics
From the themed collection: Clinical spectroscopy
Critical Review

Can mid-infrared biomedical spectroscopy of cells, fluids and tissue aid improvements in cancer survival? A patient paradigm

This review takes a fresh approach from the patient perspective; offering insight into the applications of midinfrared biomedical spectroscopy.

Graphical abstract: Can mid-infrared biomedical spectroscopy of cells, fluids and tissue aid improvements in cancer survival? A patient paradigm
From the themed collection: Clinical spectroscopy
Critical Review

Electrochemistry-based approaches to low cost, high sensitivity, automated, multiplexed protein immunoassays for cancer diagnostics

Early detection and reliable diagnostics are keys to effectively design cancer therapies with better prognoses.

Graphical abstract: Electrochemistry-based approaches to low cost, high sensitivity, automated, multiplexed protein immunoassays for cancer diagnostics
From the themed collection: Recent Review Articles
Critical Review

Detection and isolation of circulating exosomes and microvesicles for cancer monitoring and diagnostics using micro-/nano-based devices

We explore emerging micro and nano-technology that isolates and detects exosomes and microvesicles in clinical samples for cancer diagnostics.

Graphical abstract: Detection and isolation of circulating exosomes and microvesicles for cancer monitoring and diagnostics using micro-/nano-based devices
From the themed collection: Recent Review Articles
Critical Review

Microfluidics for research and applications in oncology

Cancer is currently one of the top non-communicable human diseases, and continual research and developmental efforts, particularly in microfluidics technology, are being made to better understand and manage this disease.

Graphical abstract: Microfluidics for research and applications in oncology
From the themed collection: Recent Review Articles
Communication

A universal tumor cell isolation method enabled by fibrin-coated microchannels

We found that the fibrin-immobilized surfaces on microchannels were able to capture both epithelial and mesenchymal tumor cells.

Graphical abstract: A universal tumor cell isolation method enabled by fibrin-coated microchannels
Communication

An electrochemical-TUNEL method for sensitive detection of apoptotic cells

An electrochemical-TUNEL method based on the fabrication of a CNT@PDA–FA three dimensional bio-interface was developed for cytosensors. By being coupled with a QD-based nanoprobe and electrochemical analysis, the sensor exhibited attractive performance in the detection of apoptotic cells.

Graphical abstract: An electrochemical-TUNEL method for sensitive detection of apoptotic cells
Paper

Nanoparticles of gadolinium-incorporated Prussian blue with PEG coating as an effective oral MRI contrast agent for gastrointestinal tract imaging

Nanoparticles of gadolinium-incorporated Prussian blue show potential as a cellular T1-weighted oral MRI probe for imaging the gastrointestinal tract.

Graphical abstract: Nanoparticles of gadolinium-incorporated Prussian blue with PEG coating as an effective oral MRI contrast agent for gastrointestinal tract imaging
Paper

Wavenumber selection based analysis in Raman spectroscopy improves skin cancer diagnostic specificity

Wavenumber selection based analysis with variably-sized windows was proposed, which improves skin cancer diagnostic specificity at high sensitivity levels.

Graphical abstract: Wavenumber selection based analysis in Raman spectroscopy improves skin cancer diagnostic specificity
Paper

FTIR imaging of the 3D extracellular matrix used to grow colonies of breast cancer cell lines

Infrared imaging was applied to investigate a reconstituted basement membrane, known as Matrigel, in three-dimensional cell cultures.

Graphical abstract: FTIR imaging of the 3D extracellular matrix used to grow colonies of breast cancer cell lines
Paper

Clinical evaluation of a novel microfluidic device for epitope-independent enrichment of circulating tumour cells in patients with small cell lung cancer

Evaluation of a novel microfluidic device for epitope-independent enrichment of circulating tumour cells using clinical samples from patients with SCLC.

Graphical abstract: Clinical evaluation of a novel microfluidic device for epitope-independent enrichment of circulating tumour cells in patients with small cell lung cancer
Open Access Paper

Automated analysis of single cells using Laser Tweezers Raman Spectroscopy

In recent years, significant progress has been made into the label-free detection and discrimination of individual cancer cells using Laser Tweezers Raman Spectroscopy (LTRS).

Graphical abstract: Automated analysis of single cells using Laser Tweezers Raman Spectroscopy
From the themed collection: Recent Open Access Articles
Paper

Rapid bladder cancer cell detection from clinical urine samples using an ultra-thin silicone membrane

A high-throughput strategy capable of differentiating bladder cancer cells from non-cancerous cells based on their respective cellular traction forces.

Graphical abstract: Rapid bladder cancer cell detection from clinical urine samples using an ultra-thin silicone membrane
Paper

Real-time imaging of cancer cell chemotaxis in paper-based scaffolds

An easy to assemble paper-based invasion assay to study chemotaxis of breast cancer cells in gradients of oxygen in real-time.

Graphical abstract: Real-time imaging of cancer cell chemotaxis in paper-based scaffolds
Paper

High-resolution FTIR imaging of colon tissues for elucidation of individual cellular and histopathological features

Comparison of spectral-histopathological features of a colon tissue measured using a conventional (5.5 μm × 5.5 μm, left) and a high-magnification (1.1 μm × 1.1 μm, right) FTIR imaging system with respect to HE stained tissue (middle).

Graphical abstract: High-resolution FTIR imaging of colon tissues for elucidation of individual cellular and histopathological features
Paper

Grating coupled SPR microarray analysis of proteins and cells in blood from mice with breast cancer

Grating couple surface plasmon resonance (GCSPR) microarrays can be used to analyze proteins and circulating tumor cells in mice.

Graphical abstract: Grating coupled SPR microarray analysis of proteins and cells in blood from mice with breast cancer
Paper

Characterization of human breast cancer tissues by infrared imaging

FTIR imaging allows automated identification and quantification of breast tumor cells as well as investigating tumor-related stroma alterations.

Graphical abstract: Characterization of human breast cancer tissues by infrared imaging
Open Access Paper

Microfluidics for the detection of minimal residual disease in acute myeloid leukemia patients using circulating leukemic cells selected from blood

Microfluidic assay for the selection of circulating leukemic cells from peripheral blood for the early detection of minimal residual disease in acute myeloid leukemia patients.

Graphical abstract: Microfluidics for the detection of minimal residual disease in acute myeloid leukemia patients using circulating leukemic cells selected from blood
From the themed collection: Recent Open Access Articles
Paper

Microfluidic compartments with sensing microbeads for dynamic monitoring of cytokine and exosome release from single cells

Monitoring activity of single cells has high significance for basic science and diagnostic applications.

Graphical abstract: Microfluidic compartments with sensing microbeads for dynamic monitoring of cytokine and exosome release from single cells
From the themed collection: Analyst 2016 Most Accessed Articles
Paper

Detection of DNA methyltransferase activity using allosteric molecular beacons

Abnormal DNA methylation patterns caused by altered DNA methyltransferase (MTase) activity are closely associated with cancer. Herein, using DNA adenine methylation methyltransferase (Dam MTase) as a model analyte, we designed an allosteric molecular beacon (aMB) for sensitive detection of Dam MTase activity.

Graphical abstract: Detection of DNA methyltransferase activity using allosteric molecular beacons
Paper

Identification of a p53-based portable degron based on the MDM2-p53 binding region

A shortened portable degron based on a MDM2/p53 binding region that was capable of ubiquitination in cytosolic lysates was isolated as a new substrate for analytical detection of E3 ligase or proteasome activity.

Graphical abstract: Identification of a p53-based portable degron based on the MDM2-p53 binding region
Paper

Polarity switching mass spectrometry imaging of healthy and cancerous hen ovarian tissue sections by infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI)

IR-MALDESI polarity switching mass spectrometry imaging reveals differences in lipid distribution in hen ovarian cancer tissue.

Graphical abstract: Polarity switching mass spectrometry imaging of healthy and cancerous hen ovarian tissue sections by infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI)
Paper

Naked-eye nanobiosensor for therapeutic drug monitoring of methotrexate

Sensing of methotrexate at clinically-relevant concentrations was achieved with a plasmon-coupling assay.

Graphical abstract: Naked-eye nanobiosensor for therapeutic drug monitoring of methotrexate
From the themed collection: Clinical spectroscopy
Open Access Paper

ATR-FTIR spectroscopy coupled with chemometric analysis discriminates normal, borderline and malignant ovarian tissue: classifying subtypes of human cancer

Spectrochemical discrimination of ovarian cancer.

Graphical abstract: ATR-FTIR spectroscopy coupled with chemometric analysis discriminates normal, borderline and malignant ovarian tissue: classifying subtypes of human cancer
From the themed collection: Recent Open Access Articles
34 items

About this collection

This themed collection showcases research on new technologies focused on the management of cancer-related diseases and covers a broad spectrum of new innovations including optical sensors, drug delivery vehicles, affinity agents, imaging contrast agents, microfluidics/nanofluidics and cell-based assays. Guest Edited by Steven A. Soper and Avraham Rasooly. New articles will be added to this collection as they are published.

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