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Themed collection Editor’s Collection: Bio-applications of MOFs

13 items
Highlight

Enzyme encapsulation in metal–organic frameworks for applications in catalysis

Various methods for encapsulating enzymes in metal–organic frameworks are discussed and the catalytic activity of biocomposites prepared using these methods is highlighted.

Graphical abstract: Enzyme encapsulation in metal–organic frameworks for applications in catalysis
Open Access Communication

Mechanochemical approaches towards the in situ confinement of 5-FU anti-cancer drug within MIL-100 (Fe) metal–organic framework

Low-cost mechanochemistry methods for in situ confinement of “guest” drug molecules into a “host” metal–organic framework to yield nanoscale guest@host drug delivery systems.

Graphical abstract: Mechanochemical approaches towards the in situ confinement of 5-FU anti-cancer drug within MIL-100 (Fe) metal–organic framework
Communication

Synthesis of spiny metal–phenolic coordination crystals as a sensing platform for sequence-specific detection of nucleic acids

Metal–phenolic coordination crystals with a spiny surface and tunable compositions are synthesized, and can be used as DNA sensors.

Graphical abstract: Synthesis of spiny metal–phenolic coordination crystals as a sensing platform for sequence-specific detection of nucleic acids
Communication

Biocompatible MOFs with high absolute quantum yield for bioimaging in the second near infrared window

Biocompatible mixed metal YbNd metal–organic frameworks are demonstrated to be highly efficient emitters in the second NIR window.

Graphical abstract: Biocompatible MOFs with high absolute quantum yield for bioimaging in the second near infrared window
Paper

Fabrication of a dual-emitting RhB@Zn-1 composite as a recyclable luminescent sensor for sensitive detection of nitrofuran antibiotics

A novel dual-emitting RhB@Zn-1 composite was fabricated by encapsulating RhB into the channels of Zn-1, which can serve as a recyclable sensor for sensitive and selective detection of nitrofuran antibiotics via the luminescence quenching process.

Graphical abstract: Fabrication of a dual-emitting RhB@Zn-1 composite as a recyclable luminescent sensor for sensitive detection of nitrofuran antibiotics
From the themed collection: Coordination Networks
Paper

Synthesis of fluorescent MOFs: live-cell imaging and sensing of a herbicide

Various metal–organic frameworks of Zn(II) and Cd(II) have been synthesized hydrothermally for the detection of herbicide (simazine) as well as nitro-aromatic compounds. Also these MOFs show live-cell imaging for MCF-7 cells.

Graphical abstract: Synthesis of fluorescent MOFs: live-cell imaging and sensing of a herbicide
Paper

A dye@MOF crystalline probe serving as a platform for ratiometric sensing of trichloroacetic acid (TCA), a carcinogen metabolite in human urine

Novel microporous dual-emitting dye@MOF FS@1 hybrid has been designed and prepared to effectively detect TCA, the biomarker for carcinogenic TCE in human urine.

Graphical abstract: A dye@MOF crystalline probe serving as a platform for ratiometric sensing of trichloroacetic acid (TCA), a carcinogen metabolite in human urine
Open Access Paper

Degradation of ZIF-8 in phosphate buffered saline media

Understanding the stability of zeolitic imidazolate framework-8 (ZIF-8) under physiological conditions is critical in biotechnology and biomedicine for biosensing, biocatalysis, and drug delivery.

Graphical abstract: Degradation of ZIF-8 in phosphate buffered saline media
Paper

Controlled synthesis of Fe3O4@ZIF-8 nanoparticles for drug delivery

A novel one-pot synthetic method is introduced to produce Fe3O4@ZIF-8 NPs, which are proven to have potential applications as drug delivery models.

Graphical abstract: Controlled synthesis of Fe3O4@ZIF-8 nanoparticles for drug delivery
Paper

Fluorogenic naked-eye sensing and live-cell imaging of cyanide by a hydrazine-functionalized CAU-10 metal–organic framework

A hydrazine-functionalized Al(III) based metal–organic framework was utilized for the detection of lethal cyanide in water and in living cells.

Graphical abstract: Fluorogenic naked-eye sensing and live-cell imaging of cyanide by a hydrazine-functionalized CAU-10 metal–organic framework
Paper

Two structurally diverse Zn-based coordination polymers with excellent antibacterial activity

Two novel Zn-based coordination polymers with unique structural properties display an exceptional antibacterial activity against Gram-positive and Gram-negative bacteria.

Graphical abstract: Two structurally diverse Zn-based coordination polymers with excellent antibacterial activity
Paper

A lanthanide functionalized MOF hybrid for ratiometric luminescence detection of an anthrax biomarker

A dual-emitting hybrid platform based on a lanthanide functionalized MOF was demonstrated as a fluorescent indicator for ratiometric detection of an anthrax biomarker—dipicolinic acid (DPA).

Graphical abstract: A lanthanide functionalized MOF hybrid for ratiometric luminescence detection of an anthrax biomarker
Paper

One-pot synthesis of hierarchical-pore metal–organic frameworks for drug delivery and fluorescent imaging

A one-pot process has been developed for the synthesis of hierarchical-pore metal–organic frameworks, aimed at loading large and small drug molecules simultaneously.

Graphical abstract: One-pot synthesis of hierarchical-pore metal–organic frameworks for drug delivery and fluorescent imaging
13 items

About this collection

Metal-organic Frameworks (MOFs) first captured the interest of the scientific community due to their remarkable gas adsorption properties. Subsequently, the scope of MOF chemistry swiftly expanded as researchers continued to explore and uncover new applications for these versatile materials. This Editor’s collection, guest edited by Associate Editor Christian Doonan, highlights recent contributions to CrystEngComm that are broadly focussed on bio-applications of MOFs. The selection of articles showcases the wide range of topics where MOFs are being employed to address research challenges and questions in biological science including, cellular imaging, drug delivery and release, chemical sensing, and biocatalysis. While MOFs are the common link between these studies the core concepts of crystal engineering feature prominently and thus point towards the richness and diversity of this area of chemistry.

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