Issue 27, 2020
From the journal:

CrystEngComm

Mechanochemical approaches towards the in situ confinement of 5-FU anti-cancer drug within MIL-100 (Fe) metal–organic framework†

Barbara E. Souza ORCID logo a  and  Jin-Chong Tan ORCID logo *a  

* Corresponding authors

a Multifunctional Materials and Composites (MMC) Laboratory, Department of Engineering Science, University of Oxford, Parks Road, Oxford, UK
E-mail: jin-chong.tan@eng.ox.ac.uk

Abstract

We elucidate two annealing assisted mechanochemical methods to achieve one-pot encapsulation of anti-cancer drug 5-fluorouracil (5-FU) in the iron-based MIL-100 metal–organic framework (MOF). We compare the structural and physicochemical properties of drug@MIL-100 systems derived from in situ manual and vortex grinding, where the former technique exhibits a slower drug release due to stronger guest–host interactions.

Graphical abstract: Mechanochemical approaches towards the in situ confinement of 5-FU anti-cancer drug within MIL-100 (Fe) metal–organic framework

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Article information

DOI
https://doi.org/10.1039/D0CE00638F
Article type
Communication
Submitted
28 Apr 2020
Accepted
29 Jun 2020
First published
29 Jun 2020
This article is Open Access
Creative Commons BY license

CrystEngComm, 2020,22, 4526-4530

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Mechanochemical approaches towards the in situ confinement of 5-FU anti-cancer drug within MIL-100 (Fe) metal–organic framework

B. E. Souza and J. Tan, CrystEngComm, 2020, 22, 4526 DOI: 10.1039/D0CE00638F

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