Issue 31, 2019

Degradation of ZIF-8 in phosphate buffered saline media


Understanding the stability of zeolitic imidazolate framework-8 (ZIF-8) under physiological conditions is critical in biotechnology and biomedicine for biosensing, biocatalysis, and drug delivery. The use of ZIF-8 has shown that this metal organic framework (MOF) and its derived bio-composites can degrade in presence of buffer solutions. Here we present an in-depth analysis of the structural and chemical changes of pure ZIF-8 particles exposed to phosphate buffered saline (PBS) media. Two different particle sizes (2 μm and 250 nm) were selected and the decomposition operated by 10 mM PBS (aka 1X) was studied using powder X-ray diffraction (PXRD), Fourier transformed infrared spectroscopy (FTIR), time resolved atomic force microscopy (AFM), in situ small angle X-ray scattering (SAXS), and 31P NMR.

Graphical abstract: Degradation of ZIF-8 in phosphate buffered saline media

Supplementary files

Article information

Article type
17 May 2019
07 Jun 2019
First published
08 Jun 2019
This article is Open Access
Creative Commons BY license

CrystEngComm, 2019,21, 4538-4544

Degradation of ZIF-8 in phosphate buffered saline media

M. D. J. Velásquez-Hernández, R. Ricco, F. Carraro, F. T. Limpoco, M. Linares-Moreau, E. Leitner, H. Wiltsche, J. Rattenberger, H. Schröttner, P. Frühwirt, E. M. Stadler, G. Gescheidt, H. Amenitsch, C. J. Doonan and P. Falcaro, CrystEngComm, 2019, 21, 4538 DOI: 10.1039/C9CE00757A

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