Themed collection Journal of Materials Chemistry B Emerging Investigators 2024

Stimuli-responsive controlled release systems are emerging as powerful tools for precise neuromodulation. This review summarizes the recent progress in different release mechanisms and provides insights into future research direction.

This review highlights the ring-opening polymerization strategies of LA molecules and recent biomedical applications of PLA while discussing the challenges they face and future perspectives.

A comprehensive review of the current landscape and advancements in vaccine adjuvants, providing critical insights into research, development, regulatory licensing, and potential future opportunities for enhancing vaccine efficacy and safety.

A novel drug delivery system hitchhiking albumin as a drug carrier with tuneable redox-responsive drug release.

Shifting from liquid disorder to liquid order phase in liposomes restricts the microenvironment of DI-8-ANEPPS, resulting in lengthening its fluorescence lifetime.

A hydrogel-based flexible sensor based on hydrophobicity-assisted metal ion coordination is reported for human movement monitoring and physiological signal detection.

Schematic illustration of the comparative effectiveness of myocardial patches and intramyocardial injections in the treatment of myocardial infarction using a MitoQ/hydrogel system.

Nanovaccine conjugated via a retro-Diels–Alder reaction achieves lymph node deep penetration of antigens for enhancing vaccine efficacy.

By attaching hydrophilic OEG on different conjugation sites of SN38, isomeric self-assembling prodrugs were developed and self-assembled into giant nanotubes and filamentous assemblies, revealing the critical contribution of conjugation sites.

Supramolecular DNA nanogel was constructed by host–guest interaction from Y-DNA modified with methyl violet, dsDNA with azobenzene, and curcubit[8]uril. It possess stimuli responses, excellent biocompatibility and targeted drug transport ability.

Fluorinated BPA derivatives exhibited improved ¹⁰B accumulation in tumors, and enhanced T/B and T/N ratios compared to clinical boron drug fructose-BPA (f-BPA).

Radioactive hybrid semiconducting polymer nanoparticles are developed for imaging-guided photothermal–photodynamic–sonodynamic tri-modal therapy of breast cancer.

A multifunctional nanostructure with synergistic MPTT/CDT antibacterial activities was designed for the effective treatment of wound infections.

The study focused on the fine refinement of PNIPAM-based materials, resulting in enhanced biocompatibility and drug loading for a smart hydrogel system with multi-responsive 5-FU release.

A glycolated polythiophene, p(g3T2), enables controlled drug loading/release of molecules with molecular weight of 800–6000 Da, due to large, reversible volume changes during electrochemical doping.

Reference-free traction force microscopy with a regular microdot array was designed and proposed to reveal the effects of adhesive proteins on cellular contractility, cytoskeleton structure, morphogenesis and mechanotransduction.

Design of experiments, a statistical optimization tool, was used to optimize the gelation time, compressive modulus, and stability of hydrazone-crosslinked hyaluronic acid hydrogels for controlled protein delivery.