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Themed collection Frontiers in Radionuclide Imaging and Therapy

25 items
Editorial

Frontiers in radionuclide imaging and therapy, a chemical journey from naturally radioactive elements to targeted theranostic agents

Welcome to this themed issue of Dalton Transactions entitled: ‘Frontiers in Radionuclide Imaging and Therapy; A chemical journey from naturally radioactive elements to targeted theranostic agents’.

Graphical abstract: Frontiers in radionuclide imaging and therapy, a chemical journey from naturally radioactive elements to targeted theranostic agents
From the themed collection: Frontiers in Radionuclide Imaging and Therapy
Perspective

Peptide-based fibrin-targeting probes for thrombus imaging

Herein we provide an overview of peptide-based fibrin-targeted probes developed for molecular imaging of thrombosis by different modalities with particular emphasis for nuclear imaging techniques.

Graphical abstract: Peptide-based fibrin-targeting probes for thrombus imaging
From the themed collection: Frontiers in Radionuclide Imaging and Therapy
Perspective

Fluoroquinolones as imaging agents for bacterial infection

Three ways to radioactively label fluoroquinolones are available, thereby creating multiple options for developing a diagnostic for deep-seated bacterial infection.

Graphical abstract: Fluoroquinolones as imaging agents for bacterial infection
From the themed collection: Frontiers in Radionuclide Imaging and Therapy
Perspective

Radionuclides in oncology clinical practice – review of the literature

Radionuclide therapy is a promising type of targeted therapy for cancer and its use is becoming more common in several types of malignant tumors.

Graphical abstract: Radionuclides in oncology clinical practice – review of the literature
From the themed collection: Frontiers in Radionuclide Imaging and Therapy
Perspective

Metal complexes for multimodal imaging of misfolded protein-related diseases

Aggregation of misfolded proteins and progressive polymerization of otherwise soluble proteins is a common hallmark of several highly debilitating and increasingly prevalent diseases, including amyotrophic lateral sclerosis, cerebral amyloid angiopathy, type II diabetes and Parkinson's, Huntington's and Alzheimer's diseases.

Graphical abstract: Metal complexes for multimodal imaging of misfolded protein-related diseases
From the themed collection: Frontiers in Radionuclide Imaging and Therapy
Perspective

Technetium-99m based small molecule radiopharmaceuticals and radiotracers targeting inflammation and infection

99mTc-labeled antibiotics, antifungal drugs, antimicrobial peptides and COX-2 inhibitors are comprehensively reviewed.

Graphical abstract: Technetium-99m based small molecule radiopharmaceuticals and radiotracers targeting inflammation and infection
From the themed collection: Frontiers in Radionuclide Imaging and Therapy
Frontier

99mTc-3Cboroxime: a novel 99mTc(III) complex [99mTcCl(CDO)(CDOH)2B-3C] (CDOH2 = cyclohexanedione dioxime; 3C-B(OH)2 = 3-(carbamoylphenyl)boronic acid) with high heart uptake and long myocardial retention

In this study, we found that 99mTc-3Cboroxime has the myocardial retention longer than that of 99mTc-Teboroxime, and its heart washout kinetics follows a regressive linear relationship over the 60 min period.

Graphical abstract: 99mTc-3Cboroxime: a novel 99mTc(iii) complex [99mTcCl(CDO)(CDOH)2B-3C] (CDOH2 = cyclohexanedione dioxime; 3C-B(OH)2 = 3-(carbamoylphenyl)boronic acid) with high heart uptake and long myocardial retention
From the themed collection: Frontiers in Radionuclide Imaging and Therapy
Communication

[AlCl3(BnMe2-tacn)] – a new metal chelate scaffold for radiofluorination by Cl/F exchange

Radiofluorination of [AlCl3(BnMe2-tacn)] via a Cl/F exchange reaction is described, along with a cartridge-based purification method; the [Al18F19F2(BnMe2-tacn)] exhibits excellent stability (>99% RCP after 3 h).

Graphical abstract: [AlCl3(BnMe2-tacn)] – a new metal chelate scaffold for radiofluorination by Cl/F exchange
From the themed collection: Frontiers in Radionuclide Imaging and Therapy
Paper

Chemistry and radiochemistry of As, Re and Rh isotopes relevant to radiopharmaceutical applications: high specific activity radionuclides for imaging and treatment

Advances in production, separation, target recovery, and chelation chemistry of high specific activity radionuclides will promote new theranostic agent development.

Graphical abstract: Chemistry and radiochemistry of As, Re and Rh isotopes relevant to radiopharmaceutical applications: high specific activity radionuclides for imaging and treatment
From the themed collection: Frontiers in Radionuclide Imaging and Therapy
Open Access Paper

Measurement of reaction kinetics of [177Lu]Lu-DOTA-TATE using a microfluidic system

Design and evaluation of a microfluidic system that allowed the determination of Arrhenius parameters for the formation of [177Lu]Lu-DOTA-TATE using clinical radiolabeling conditions.

Graphical abstract: Measurement of reaction kinetics of [177Lu]Lu-DOTA-TATE using a microfluidic system
From the themed collection: Frontiers in Radionuclide Imaging and Therapy
Paper

H4octapa: synthesis, solution equilibria and complexes with useful radiopharmaceutical metal ions

H4octapa is synthesized and complexed to nine metals of medicinal interest. Crystal structures of the ligand and its La complex were obtained. Solution equilibria for the ligand and several lanthanide complexes were investigated.

Graphical abstract: H4octapa: synthesis, solution equilibria and complexes with useful radiopharmaceutical metal ions
From the themed collection: Frontiers in Radionuclide Imaging and Therapy
Paper

Clinical evaluation of the radiolanthanide terbium-152: first-in-human PET/CT with 152Tb-DOTATOC

The existence of theragnostic pairs of radionuclides allows the preparation of radiopharmaceuticals for diagnostic and therapeutic purposes.

Graphical abstract: Clinical evaluation of the radiolanthanide terbium-152: first-in-human PET/CT with 152Tb-DOTATOC
From the themed collection: Frontiers in Radionuclide Imaging and Therapy
Paper

MANOTA: a promising bifunctional chelating agent for copper-64 immunoPET

A comparison of four bifunctional chelating agents showed superior behaviour of a new NOTA derivative for 64Cu labelling of antibody fragments.

Graphical abstract: MANOTA: a promising bifunctional chelating agent for copper-64 immunoPET
From the themed collection: Frontiers in Radionuclide Imaging and Therapy
Paper

Structure and reactivities of rhenium and technetium bis-arene sandwich complexes [M(η6-arene)2]+

Rhenium and 99Tc bis-arene complexes for a molecule-based theranostic approach are presented. Conjugation of biovectors to benzene or substitution of naphthalene allows integration of {Re(η6-C6H6)}+ in pharmaceutical lead structures.

Graphical abstract: Structure and reactivities of rhenium and technetium bis-arene sandwich complexes [M(η6-arene)2]+
From the themed collection: Frontiers in Radionuclide Imaging and Therapy
Paper

Copper complexes with dissymmetrically substituted bis(thiosemicarbazone) ligands as a basis for PET radiopharmaceuticals: control of redox potential and lipophilicity

A library of copper(II) bis(thiosemicarbazone) complexes offers independently controlled redox potential and lipophilicity for optimal 64Cu PET tracer design.

Graphical abstract: Copper complexes with dissymmetrically substituted bis(thiosemicarbazone) ligands as a basis for PET radiopharmaceuticals: control of redox potential and lipophilicity
From the themed collection: Frontiers in Radionuclide Imaging and Therapy
Paper

Comparative studies on the therapeutic benefit of targeted α-particle radiation therapy for the treatment of disseminated intraperitoneal disease

Choosing an appropriate α-emitter for targeted therapy resides in multiple variables beyond efficacy such as the economics of injected dose.

Graphical abstract: Comparative studies on the therapeutic benefit of targeted α-particle radiation therapy for the treatment of disseminated intraperitoneal disease
From the themed collection: Frontiers in Radionuclide Imaging and Therapy
Paper

In vitro and in vivo trackable titanocene-based complexes using optical imaging or SPECT

Two unprecedented titanocene-based theranostics have been synthesized, characterized, and tracked either in vitro (BODIPY probe) or in vivo (111In-DOTA probe).

Graphical abstract: In vitro and in vivo trackable titanocene-based complexes using optical imaging or SPECT
From the themed collection: Frontiers in Radionuclide Imaging and Therapy
Paper

Fast and cost-effective cyclotron production of 61Cu using a natZn liquid target: an opportunity for radiopharmaceutical production and R&D

Following our previous work on the production of radiometals, such as 64Cu and 68Ga, through the irradiation of liquid targets using a medical cyclotron, we describe in this paper a technique to produce 61Cu through the irradiation of natural zinc using a liquid target.

Graphical abstract: Fast and cost-effective cyclotron production of 61Cu using a natZn liquid target: an opportunity for radiopharmaceutical production and R&D
From the themed collection: Frontiers in Radionuclide Imaging and Therapy
Paper

Novel bifunctional DATA chelator for quick access to site-directed PET 68Ga-radiotracers: preclinical proof-of-principle with [Tyr3]octreotide

Comparison of 68Ga-DATA-TOC vs. 68Ga-DOTA-TOC in sst2-positive cells and tumor-bearing mice revealed the suitability of DATA for easy access to 68Ga-labeled vectors.

Graphical abstract: Novel bifunctional DATA chelator for quick access to site-directed PET 68Ga-radiotracers: preclinical proof-of-principle with [Tyr3]octreotide
From the themed collection: Frontiers in Radionuclide Imaging and Therapy
Paper

Thiourea derivatives as chelating agents for bioconjugation of rhenium and technetium

A 99mTc complex with a tetradentate thiocarbamoylbenzamidine group was used for the conjugation of angiotensin-II. The resulting bioconjugate is stable in vivo and in vitro.

Graphical abstract: Thiourea derivatives as chelating agents for bioconjugation of rhenium and technetium
From the themed collection: Frontiers in Radionuclide Imaging and Therapy
Paper

Preparation of tetrazine-containing [2 + 1] complexes of 99mTc and in vivo targeting using bioorthogonal inverse electron demand Diels–Alder chemistry

A new 99mTc-labelled tetrazine for targeted imaging using bioorthogonal chemistry was developed and evaluated in vivo using a trans-cyclooctene derived bisphosphonate targeting regions of high bone turnover and bone lesions.

Graphical abstract: Preparation of tetrazine-containing [2 + 1] complexes of 99mTc and in vivo targeting using bioorthogonal inverse electron demand Diels–Alder chemistry
From the themed collection: CSC100: Celebrating Canadian Chemistry
Paper

Technetium-99m complexes of L-arginine derivatives for targeting amino acid transporters

The metal complex Tc2 exhibits relevant internalization in several cancer cell lines, likely to be mediated by cationic amino acid transporters.

Graphical abstract: Technetium-99m complexes of l-arginine derivatives for targeting amino acid transporters
From the themed collection: Frontiers in Radionuclide Imaging and Therapy
Paper

Mangiferin functionalized radioactive gold nanoparticles (MGF-198AuNPs) in prostate tumor therapy: green nanotechnology for production, in vivo tumor retention and evaluation of therapeutic efficacy

We report here production of MGF-198AuNPs and its application for prostate tumor therapy.

Graphical abstract: Mangiferin functionalized radioactive gold nanoparticles (MGF-198AuNPs) in prostate tumor therapy: green nanotechnology for production, in vivo tumor retention and evaluation of therapeutic efficacy
From the themed collection: Frontiers in Radionuclide Imaging and Therapy
Paper

In vitro/in vivo “peeling” of multilayered aminocarboxylate gold nanoparticles evidenced by a kinetically stable 99mTc-label

The BBN-Au-DTDTPA coating is selectively released upon interaction with glutathione (GSH), rendering this nanoplatform potentially useful for GSH-mediated drug delivery.

Graphical abstract: In vitro/in vivo “peeling” of multilayered aminocarboxylate gold nanoparticles evidenced by a kinetically stable 99mTc-label
From the themed collection: Frontiers in Radionuclide Imaging and Therapy
Paper

Combining imaging and anticancer properties with new heterobimetallic Pt(II)/M(I) (M = Re, 99mTc) complexes

New metal-based anticancer agents with imaging, chemotherapeutic and photosensitizing properties.

Graphical abstract: Combining imaging and anticancer properties with new heterobimetallic Pt(ii)/M(i) (M = Re, 99mTc) complexes
From the themed collection: Frontiers in Radionuclide Imaging and Therapy
25 items

About this collection

This special issue guest-edited by Professors Angela Casini, João Correia and Chris Orvig will highlight emerging trends in the use of radionuclides, namely radiometals, for molecular imaging and systemic radiotherapy. It intends to cover all aspects of the use of radionuclides in biomedical/clinical applications.

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