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Metal complexes for multimodal imaging of misfolded protein-related diseases

Abstract

Aggregation of misfolded proteins and progressive polymerization of otherwise soluble proteins is a common hallmark of a wide range of highly debilitating and increasingly prevalent diseases, including Amyotrophic Lateral Sclerosis, Cerebral Amyloid Angiopathy, Type II Diabetes and Parkinson’s, Huntington’s and Alzheimer’s diseases. There is a growing interest in creating imaging agents to detect such aggregates in various imaging modalities, including PET, SPECT and MRI. We present here an overview of recent efforts in the perspective of early diagnosis of amyloid diseases, with a major focus on Aβ detection and on metal complexes bearing PiB units.

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Publication details

The article was received on 30 Jun 2017, accepted on 07 Sep 2017 and first published on 07 Sep 2017


Article type: Perspective
DOI: 10.1039/C7DT02371E
Citation: Dalton Trans., 2017, Accepted Manuscript
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    Metal complexes for multimodal imaging of misfolded protein-related diseases

    S. Lacerda, J. Morfin, C. F.G.C. Geraldes and E. Toth, Dalton Trans., 2017, Accepted Manuscript , DOI: 10.1039/C7DT02371E

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