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Issue 42, 2017
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In vitro and in vivo trackable titanocene-based complexes using optical imaging or SPECT

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Abstract

A novel Ti/111In-heterometallic radiotheranostic along with non-radioactive Ti/In, Ti/Lu, and Ti/Y analogues has been reported, thanks to the design of a challenging synthesis of the first titanocene-DOTA ligand. The corresponding titanocene-BODIPY complex was developed for in vitro tracking by optical imaging. The different complexes were characterized and their antiproliferative properties were evaluated on three cancer cell lines (A2780, B16F1, and PC3). As a proof of concept, initial studies in healthy mice were performed with a Ti/111In derivative to obtain information about its uptake, its biodistribution, and its excretion. Confocal microscopy experiments were performed with fluorescent complexes to track it in vitro.

Graphical abstract: In vitro and in vivo trackable titanocene-based complexes using optical imaging or SPECT

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Publication details

The article was received on 01 Jun 2017, accepted on 27 Jun 2017 and first published on 27 Jun 2017


Article type: Paper
DOI: 10.1039/C7DT01981E
Citation: Dalton Trans., 2017,46, 14548-14555
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    In vitro and in vivo trackable titanocene-based complexes using optical imaging or SPECT

    O. Florès, A. Trommenschlager, S. Amor, F. Marques, F. Silva, L. Gano, F. Denat, M. P. Cabral Campello, C. Goze, E. Bodio and P. Le Gendre, Dalton Trans., 2017, 46, 14548
    DOI: 10.1039/C7DT01981E

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