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Peptide-Based Fibrin-Targeting Probes for Thrombus Imaging

Abstract

The development of new methods to image the onset and progression of thrombosis is an unmet need. Non-invasive molecular imaging techniques targeting specific key structures involved in the formation of thrombosis have demonstrated the ability to detect thrombus in different disease state models and in patients. Due to its high concentration in the thrombus and its essential role in thrombus formation, the detection of fibrin is an attractive strategy for identification of thrombosis. Herein we provide an overview of recent and selected fibrin-targeted probes for molecular imaging of thrombosis by magnetic resonance imaging (MRI), positron emission tomography (PET), single photon emission computed tomography (SPECT), and optical techniques. Emphasis is placed on work that our lab has explored over the last 15 years that has resulted in the progression of the fibrin-binding PET probe [64Cu]FBP8 from preclinical studies into human trials.

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Publication details

The article was received on 20 Jul 2017, accepted on 12 Oct 2017 and first published on 12 Oct 2017


Article type: Perspective
DOI: 10.1039/C7DT02634J
Citation: Dalton Trans., 2017, Accepted Manuscript
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    Peptide-Based Fibrin-Targeting Probes for Thrombus Imaging

    B. Oliveira and P. Caravan, Dalton Trans., 2017, Accepted Manuscript , DOI: 10.1039/C7DT02634J

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