Themed collection Nanozymes

75 items - Showing page 1 of 2
Editorial

Introduction to nanozymes

This Editorial written by Guest Editors Professors Shaoqin Liu, Vincent Rotello, Asier Unciti-Broceta and Hui Wei introduces the themed collection on nanozymes in Journal of Materials Chemistry B and Nanoscale.

Graphical abstract: Introduction to nanozymes
From the themed collection: Nanozymes
Perspective

Peroxidase mimics of platinum-group metals for in vitro diagnostics: opportunities and challenges

This perspective discusses fundamentally important issues and practically useful viewpoints of platinum-group metal peroxidase mimics from the aspects of materials science and solid-state chemistry.

Graphical abstract: Peroxidase mimics of platinum-group metals for in vitro diagnostics: opportunities and challenges
From the themed collection: Nanozymes
Open Access Minireview

An emerging direction for nanozyme design: from single-atom to dual-atomic-site catalysts

This mini-review captures the emerging direction of nanozymes and presents a comprehensive overview of dual-atomic site nanozymes. It guides the exploration of next-generation nanozymes and inspires further innovation in the field.

Graphical abstract: An emerging direction for nanozyme design: from single-atom to dual-atomic-site catalysts
From the themed collection: Nanozymes
Minireview

Advances in the application of metal–organic framework nanozymes in colorimetric sensing of heavy metal ions

In this minireview, the preparation methods and catalytic mechanisms of MOFs-based nanozymes were mainly described. Furthermore, the applications of MOFs-based nanozymes in the colorimetric sensing platform of heavy metal ions were demonstrated.

Graphical abstract: Advances in the application of metal–organic framework nanozymes in colorimetric sensing of heavy metal ions
From the themed collection: Recent Review Articles
Minireview

Nanozyme: a rising star for cancer therapy

Tumor therapy by nanozymes.

Graphical abstract: Nanozyme: a rising star for cancer therapy
From the themed collection: Recent Review Articles
Review Article

Enhancing electrochemical sensing through the use of functionalized graphene composites as nanozymes

+ Different categories of artificial enzymes (nanozymes) according to the type of graphene derivative.

Graphical abstract: Enhancing electrochemical sensing through the use of functionalized graphene composites as nanozymes
Review Article

Single-atom nanozymes: classification, regulation strategy, and safety concerns

This review categorizes and describes the applications of SAzymes, explores methods for regulating their activity, and provides a comprehensive overview of the biosafety challenges associated with these enzymes.

Graphical abstract: Single-atom nanozymes: classification, regulation strategy, and safety concerns
From the themed collection: Nanozymes
Review Article

Cascade strategy for glucose oxidase-based synergistic cancer therapy using nanomaterials

Nanomaterial-based cancer therapy faces significant limitations due to the complex nature of the tumor microenvironment (TME).

Graphical abstract: Cascade strategy for glucose oxidase-based synergistic cancer therapy using nanomaterials
From the themed collection: Nanozymes
Review Article

Nucleic acid-functionalized nanozymes and their applications

Nucleic acid-modified nanozymes provide hybrid nanostructures that act as sensors, effective catalysts and bioreactor systems, DNA switches and catalysts for nano-biomedical applications.

Graphical abstract: Nucleic acid-functionalized nanozymes and their applications
From the themed collection: Recent Review Articles
Open Access Review Article

Anti-inflammatory potential of platinum nanozymes: mechanisms and perspectives

PtNPs hold great potential as anti-inflammatory agents, regulating the ROS-mediated recruitment and activation of immune system components.

Graphical abstract: Anti-inflammatory potential of platinum nanozymes: mechanisms and perspectives
From the themed collection: Recent Review Articles
Review Article

Antioxidative 0-dimensional nanodrugs overcome obstacles in AKI antioxidant therapy

Schematic illustration of 0D nanodrugs for AKI treatment. (a) Pathological features of renal tubular injury and glomerular filtration barrier in AKI. (b) Three categories of 0D nanomaterials applied to nanodrugs surrounding AKI antioxidant therapy.

Graphical abstract: Antioxidative 0-dimensional nanodrugs overcome obstacles in AKI antioxidant therapy
From the themed collection: Nanozymes
Review Article

Antioxidant nanozymes in kidney injury: mechanism and application

Excessive production of reactive oxygen species (ROS) in the kidneys is involved in the pathogenesis of kidney diseases, such as acute kidney injury (AKI) and diabetic kidney disease (DKD), and is the main reason for the progression of kidney injury.

Graphical abstract: Antioxidant nanozymes in kidney injury: mechanism and application
From the themed collection: Recent Review Articles
Review Article

Prussian blue nanozymes: progress, challenges, and opportunities

Prussian blue nanozymes: unlocking new horizons in catalysis and biomedicine – a comprehensive review of the progress, addressing challenges, and exploring limitless opportunities.

Graphical abstract: Prussian blue nanozymes: progress, challenges, and opportunities
From the themed collection: Recent Review Articles
Review Article

Advances and perspectives of nanozymes in respiratory diseases

This is a systematic review of advances and perspectives of nanozymes in respiratory diseases, which will inspire communities of researchers and build a bridge between nanozymes and respiratory medicine.

Graphical abstract: Advances and perspectives of nanozymes in respiratory diseases
From the themed collection: Nanozymes
Review Article

Development of nanozyme based sensors as diagnostic tools in clinic applications: a review

Nanozyme-based sensors in the field of healthcare.

Graphical abstract: Development of nanozyme based sensors as diagnostic tools in clinic applications: a review
From the themed collection: Nanozymes
Review Article

Recent progress in nanozymes for the treatment of diabetic wounds

In this review, the recent advance in nanozymes to promote diabetic wound healing was summarized from bacterial clearance, glucoregulation, and inflammation elimination.

Graphical abstract: Recent progress in nanozymes for the treatment of diabetic wounds
From the themed collection: Nanozymes
Review Article

Machine learning facilitating the rational design of nanozymes

Nanozymes face challenges in creating high-performance variants quickly. Machine learning shows promise in addressing this obstacle by predicting the activity, selectivity, catalytic mechanisms, optimal structures, and other features of nanozymes.

Graphical abstract: Machine learning facilitating the rational design of nanozymes
From the themed collection: Nanozymes
Review Article

The rational design of nanozymes for imaging-monitored cancer therapy

Nanomaterial-based nanozymes with the activities of different natural enzymes have been applied in tumor therapy and multiple imaging tools to monitor the catalytic activities.

Graphical abstract: The rational design of nanozymes for imaging-monitored cancer therapy
From the themed collection: Nanozymes
Review Article

Design of carbon dots as nanozymes to mediate redox biological processes

Fluorescent carbon dot nanozymes with multi-enzyme activities can mediate redox biological processes. Various strategies which mimic natural enzymes can be used to improve their catalytic activity and specificity.

Graphical abstract: Design of carbon dots as nanozymes to mediate redox biological processes
From the themed collection: Nanozymes
Review Article

Ferritin nanocages: a versatile platform for nanozyme design

Overview of ferritin nanocage and ferritin nanozyme. The ferritin nanocages hold different modified interfaces of protein structure (upper). Ferritin nanozymes show various enzyme-like activities for different biomedical applications (bottom).

Graphical abstract: Ferritin nanocages: a versatile platform for nanozyme design
From the themed collection: Nanozymes
Communication

CuCeTA nanoflowers as an efficient peroxidase candidate for direct colorimetric detection of glyphosate

A CuCeTA nanozyme was designed as a peroxidase mimic for intelligent colorimetric detection of glyphosate.

Graphical abstract: CuCeTA nanoflowers as an efficient peroxidase candidate for direct colorimetric detection of glyphosate
From the themed collection: Nanozymes
Communication

Amplification of oxidative stress by lipid surface-coated single-atom Au nanozymes for oral cancer photodynamic therapy

Single-atom nanozymes (SANs) are the latest trend in biomaterials research and promote the application of single atoms in biological fields and the realization of protein catalysis in vivo with inorganic nanoparticles.

Graphical abstract: Amplification of oxidative stress by lipid surface-coated single-atom Au nanozymes for oral cancer photodynamic therapy
From the themed collection: Nanozymes
Communication

Tuning the enzyme-like activity of peptide–nanoparticle conjugates with amino acid sequences

Peptide–nanoparticle conjugates show hydrolase-like activity, which is tuned by amino acid sequences.

Graphical abstract: Tuning the enzyme-like activity of peptide–nanoparticle conjugates with amino acid sequences
From the themed collection: Nanozymes
Communication

A cascade nanozyme with antimicrobial effects against nontypeable Haemophilus influenzae

A cascade nanozyme with glucose oxidase and haloperoxidase activities was designed and synthesized, which was shown to generate antiseptic HOBr from a ubiquitous non-ROS, O2. It successfully inhibited growth of a bacterial pathogen and its biofilm.

Graphical abstract: A cascade nanozyme with antimicrobial effects against nontypeable Haemophilus influenzae
From the themed collection: Nanozymes
Open Access Paper

Design of a gold nanoparticles site in an engineered lipase: an artificial metalloenzyme with enantioselective reductase-like activity

A new approach for the synthesis of gold nanoparticles-enzyme conjugates with enantioselective reductase-like activity has been developed.

Graphical abstract: Design of a gold nanoparticles site in an engineered lipase: an artificial metalloenzyme with enantioselective reductase-like activity
From the themed collection: Nanozymes
Paper

Diagnosis of Mycobacterium tuberculosis using palladium–platinum bimetallic nanoparticles combined with paper-based analytical devices

This study demonstrates that palladium–platinum bimetallic nanoparticles (Pd@Pt NPs) can be used as the nanozyme for highly sensitive Mycobacterium tuberculosis diagnosis on a multi-layer paper-based analytical device.

Graphical abstract: Diagnosis of Mycobacterium tuberculosis using palladium–platinum bimetallic nanoparticles combined with paper-based analytical devices
From the themed collection: Nanozymes
Paper

Construction of a highly efficient DNA nanotube sensor with peroxide-like activity

DNTzyme with enhanced enzymatic activity and excellent stability was constructed by loading of DNAzyme on DNA nanotubes.

Graphical abstract: Construction of a highly efficient DNA nanotube sensor with peroxide-like activity
From the themed collection: Nanozymes
Paper

Mitochondria-targeting nanozyme alleviating temporomandibular joint pain by inhibiting the TNFα/NF-κB/NEAT1 pathway

Mitochondria-targeting MOF-based nanozyme alleviating temporomandibular joint pain by inhibiting the TNFα/NF-κB/NEAT1 pathway based on oxidative stress regulation.

Graphical abstract: Mitochondria-targeting nanozyme alleviating temporomandibular joint pain by inhibiting the TNFα/NF-κB/NEAT1 pathway
From the themed collection: Nanozymes
Paper

2D-MoS2-supported copper peroxide nanodots with enhanced nanozyme activity: application in antibacterial activity

Peroxidase (POD)-like nanozymes are an upcoming class of new-generation antibiotics that are efficient for broad-spectrum antibacterial action.

Graphical abstract: 2D-MoS2-supported copper peroxide nanodots with enhanced nanozyme activity: application in antibacterial activity
From the themed collection: Nanozymes
Paper

Ultrasmall calcium-enriched Prussian blue nanozymes promote chronic wound healing by remodeling the wound microenvironment

Ultrasmall CaPB NPs fabricated via a simple and feasible route with high yields have promising potential for accelerating wound healing through antioxidant activity, anti-inflammatory activity and vascularization promotion.

Graphical abstract: Ultrasmall calcium-enriched Prussian blue nanozymes promote chronic wound healing by remodeling the wound microenvironment
From the themed collection: Nanozymes
Paper

Spherical porous iron–nitrogen–carbon nanozymes derived from a tannin coordination framework for the preparation of L-DOPA by emulating tyrosine hydroxylase

L-DOPA is widely used in Parkinson's disease treatment. A spherical porous Iron-Nitrogen-Carbon nanozyme was developed for biomimetic synthesis of L-DOPA by emulating tyrosine hydroxylase.

Graphical abstract: Spherical porous iron–nitrogen–carbon nanozymes derived from a tannin coordination framework for the preparation of l-DOPA by emulating tyrosine hydroxylase
From the themed collection: Nanozymes
Paper

A pH-responsive supramolecular hydrogel encapsulating a CuMnS nanoenzyme catalyst for synergistic photothermal–photodynamic–chemodynamic therapy of tumours

A pH-responsive supramolecular hydrogel encapsulating a CuMnS nanoenzyme catalyst was fabricated for synergistic photothermal–photodynamic–chemotherapy of tumours.

Graphical abstract: A pH-responsive supramolecular hydrogel encapsulating a CuMnS nanoenzyme catalyst for synergistic photothermal–photodynamic–chemodynamic therapy of tumours
From the themed collection: Nanozymes
Paper

Coal waste-derived synthesis of yellow oxidized graphene quantum dots with highly specific superoxide dismutase activity: characterization, kinetics, and biological studies

The remediation of coal waste into YGQDs with SOD-specific activity and superoxide ion binding in nanomolar range is reported for the first time. The molecular mechanism of its antioxidative and antiapoptotic properties are confirmed in C6-cells.

Graphical abstract: Coal waste-derived synthesis of yellow oxidized graphene quantum dots with highly specific superoxide dismutase activity: characterization, kinetics, and biological studies
From the themed collection: Graphene and 2D Materials in Healthcare
Open Access Paper

Ruptured organosilica nanocapsules immobilized acetylcholinesterase coupled with MnO2 nanozyme for screening inhibitors from Inula macrophylla

A platform of RONs immobilized AChE coupled with an MnO2-OPD colorimetric assay was established for screening inhibitors.

Graphical abstract: Ruptured organosilica nanocapsules immobilized acetylcholinesterase coupled with MnO2 nanozyme for screening inhibitors from Inula macrophylla
From the themed collection: Nanozymes
Paper

Exploring the potential of iron-based metal–organic frameworks as peroxidase nanozymes for glucose detection with various secondary building units

This study investigated different secondary building units of iron-based metal–organic frameworks and discovered that when combined with an enzyme-encapsulating ZIF-90 PVP MOF, they could be sequentially employed for glucose detection purposes.

Graphical abstract: Exploring the potential of iron-based metal–organic frameworks as peroxidase nanozymes for glucose detection with various secondary building units
Open Access Paper

Nanozymes with versatile redox capabilities inspired in metalloenzymes

Engineered artificial metalloenzymes based on protein-templated Pt nanoclusters yield highly efficient nanozymes serving as redox catalysts.

Graphical abstract: Nanozymes with versatile redox capabilities inspired in metalloenzymes
Paper

A nanozyme-reinforced injectable photodynamic hydrogel for combating biofilm infection

Here, an oxygen self-supplying nanozyme-based injectable hydrogel is constructed. Both in vitro and in vivo results indicate that the MTC gel has excellent antibiofilm ability with no side effects on normal tissues.

Graphical abstract: A nanozyme-reinforced injectable photodynamic hydrogel for combating biofilm infection
From the themed collection: Injectable Hydrogels
Paper

Bismuth nanoclusters on nitrogen-doped porous carbon nanoenzyme for cancer therapy

We have designed a highly efficient bismuth nanocluster supported on nitrogen-doped porous carbon as a nanozyme (Bi-NC) for cancer therapy. At the same time, Bi-NC shows good photothermal conversion performance to generate heat for strengthening the therapy.

Graphical abstract: Bismuth nanoclusters on nitrogen-doped porous carbon nanoenzyme for cancer therapy
Paper

Tetrahedral DNA nanostructure-corbelled click chemistry-based large-scale assembly of nanozymes for ratiometric fluorescence assay of DNA methyltransferase activity

We engineer DTN-corbelled click chemistry to trigger a HCR assembling a large-scale of nanozymes for ratiometric fluorescence detection of DNA Dam. The biosensor displayed a low detection limit of 0.001 U mL−1 for Dam MTase and was effective in real sample and methylation inhibitor screenings.

Graphical abstract: Tetrahedral DNA nanostructure-corbelled click chemistry-based large-scale assembly of nanozymes for ratiometric fluorescence assay of DNA methyltransferase activity
From the themed collection: Nanozymes
Paper

pH-Switchable phenylalanine-templated copper nanoclusters: CO2 probing and efficient peroxidase mimicking activity

Inter-cluster conversion through the strategic tuning of external stimuli and thereby modulation of the optical properties of metal nanoclusters (MNCs) is an emerging domain for exploration.

Graphical abstract: pH-Switchable phenylalanine-templated copper nanoclusters: CO2 probing and efficient peroxidase mimicking activity
From the themed collection: Nanozymes
Open Access Paper

Polymeric architecture as a tool for controlling the reactivity of palladium(II) loaded nanoreactors

The architecture of the hydrophobic dendritic block in linear-dendron amphiphiles is employed as a means to control the reactivity of self-assembled micellar nanoreactors.

Graphical abstract: Polymeric architecture as a tool for controlling the reactivity of palladium(ii) loaded nanoreactors
From the themed collection: Nanozymes
Paper

Fe(III)-incorporated porphyrin-based conjugated organic polymer as a peroxidase mimic for the sensitive determination of glucose and H2O2

An Fe(III)-incorporated porphyrin-based conjugated organic polymer is reported as a nanozyme for the efficient detection of glucose via intrinsic peroxidase activity and amperometric detection of H2O2.

Graphical abstract: Fe(iii)-incorporated porphyrin-based conjugated organic polymer as a peroxidase mimic for the sensitive determination of glucose and H2O2
From the themed collection: Nanozymes
Paper

Dual enzyme-mimicking carbon dots for enhanced antibacterial activity

Carbon dot (CD)-based nanozymes have great potential in antibacterial applications through the design of the structure.

Graphical abstract: Dual enzyme-mimicking carbon dots for enhanced antibacterial activity
From the themed collection: Nanozymes
Paper

A tumor cell exosome-mimicking multifunctional nanozyme for targeted breast cancer radiotherapy

A multifunctional nanozyme that mimics tumor cell exosomes (CuPy-Au@EM) was fabricated in this work for achieving a highly effective and secure cancer radiotherapy regimen.

Graphical abstract: A tumor cell exosome-mimicking multifunctional nanozyme for targeted breast cancer radiotherapy
From the themed collection: Nanozymes
Paper

Light-gated specific oxidase-like activity of a self-assembled Pt(II) nanozyme for environmental remediation

A synthetic Pt(II) complex self-assembles in water, exhibiting photo-induced specific oxidase enzyme-like properties. We demonstrate robust environmental remediation using the artificial enzyme equivalent under visible light and sunlight.

Graphical abstract: Light-gated specific oxidase-like activity of a self-assembled Pt(ii) nanozyme for environmental remediation
From the themed collection: Nanozymes
Paper

Conservation of the enzyme-like activity and biocompatibility of CeO2 nanozymes in simulated body fluids

CeO2 nanozymes dispersed for 7 days in simulated body fluids maintain excellent biocompatibility and antioxidant properties. This work provides an experimental basis to explain their in vivo therapeutic effectiveness against chronic inflammation.

Graphical abstract: Conservation of the enzyme-like activity and biocompatibility of CeO2 nanozymes in simulated body fluids
From the themed collection: Nanozymes
Open Access Paper

Platinum-based nanodendrites as glucose oxidase-mimicking surrogates

Defining Pt nanodendrites as glucose oxidase-mimicking surrogates while establishing the most suitable calculation and detection approaches.

Graphical abstract: Platinum-based nanodendrites as glucose oxidase-mimicking surrogates
From the themed collection: Nanozymes
Paper

NiCo LDH nanozymes with selective antibacterial activity against Gram-negative bacteria for wound healing

Schematic diagram of Ni4Co6 LDHs selectively killing Gram-negative bacteria and interacting with different bacterial membranes.

Graphical abstract: NiCo LDH nanozymes with selective antibacterial activity against Gram-negative bacteria for wound healing
From the themed collection: Nanozymes
Paper

Targeted treatment of gouty arthritis by biomineralized metallic nanozyme-mediated oxidative stress-mitigating nanotherapy

Targeted delivery of ceria nanozymes depletes oxidative stress in inflammatory macrophage cells and alleviates gouty arthritis symptoms by suppressing inflammatory signals.

Graphical abstract: Targeted treatment of gouty arthritis by biomineralized metallic nanozyme-mediated oxidative stress-mitigating nanotherapy
From the themed collection: Nanozymes
Paper

Biodegradable nanoemulsion-based bioorthogonal nanocatalysts for intracellular generation of anticancer therapeutics

A biodegradable nanoemulsion to encapsulate hydrophobic transition metal catalysts (TMCs) and perform intracellular bioorthogonal activation of prodrugs for anticancer therapy.

Graphical abstract: Biodegradable nanoemulsion-based bioorthogonal nanocatalysts for intracellular generation of anticancer therapeutics
From the themed collection: Nanozymes
Paper

Construction of mPt/ICG-αA nanoparticles with enhanced phototherapeutic activities for multidrug-resistant bacterial eradication and wound healing

Novel composite nanoparticles mPt/ICG-αA, which combine catalase-like, photodynamic, photothermal, and α-amylase hydrolysis properties, have been developed for multidrug-resistant bacterial eradication and wound healing.

Graphical abstract: Construction of mPt/ICG-αA nanoparticles with enhanced phototherapeutic activities for multidrug-resistant bacterial eradication and wound healing
From the themed collection: Nanozymes
Paper

A Ce-MOF@polydopamine composite nanozyme as an efficient scavenger for reactive oxygen species and iron in thalassemia disease therapy

A Ce-MOF@PDA composite material with both iron-eliminating and antioxidant properties was developed.

Graphical abstract: A Ce-MOF@polydopamine composite nanozyme as an efficient scavenger for reactive oxygen species and iron in thalassemia disease therapy
From the themed collection: Nanozymes
Open Access Paper

Pd nanocatalysts adsorbed onto silica nanoparticle coated indium tin oxide: a reusable nanozyme for glucose detection

Nanozymes based on the chemisorption of PdNPs nanocatalysts onto silica nanoparticles modified ITO for the colorimetric detection of glucose.

Graphical abstract: Pd nanocatalysts adsorbed onto silica nanoparticle coated indium tin oxide: a reusable nanozyme for glucose detection
From the themed collection: Nanozymes
Paper

Enhanced peroxidase-like activity of MOF nanozymes by co-catalysis for colorimetric detection of cholesterol

MoCu-2MI was synthesized using Mo-doped Cu-2MI and exhibited enhanced peroxidase-like activity through the co-catalytic Fenton reaction.

Graphical abstract: Enhanced peroxidase-like activity of MOF nanozymes by co-catalysis for colorimetric detection of cholesterol
From the themed collection: Nanozymes
Paper

DNA-modulated single-atom nanozymes with enhanced enzyme-like activity for ultrasensitive detection of dopamine

DNA can act as an auxiliary regulator via a straightforward incubation method with Fe–N–C SAzymes, causing a leap in the enzyme-like activity of Fe–N–C from moderate to a higher level.

Graphical abstract: DNA-modulated single-atom nanozymes with enhanced enzyme-like activity for ultrasensitive detection of dopamine
From the themed collection: Nanozymes
Paper

Organic compound-based nanozymes for agricultural herbicide detection

Illustrated summary of the OC nanozyme and glyphosate detection with it.

Graphical abstract: Organic compound-based nanozymes for agricultural herbicide detection
From the themed collection: Nanozymes
Open Access Paper

Amphiphilic polymeric nanoparticles enable homogenous rhodium-catalysed NH insertion reactions in living cells

Hydrophobic dirhodium complexes embedded into amphiphilic nanoparticles catalyse efficiently the in vitro formation of fluorescent and cytotoxic quinoxalines.

Graphical abstract: Amphiphilic polymeric nanoparticles enable homogenous rhodium-catalysed NH insertion reactions in living cells
From the themed collection: Nanozymes
Paper

A nucleotide–copper(II) complex possessing a monooxygenase-like catalytic function

We present a Cu2+-nucleotide catalyst that enables ortho-hydroxylation reactions of phenols. The results provide evidence for the generation of HO2 radicals facilitated by a hydrogen bonding network. Notably, this system demonstrates improved thermostability.

Graphical abstract: A nucleotide–copper(ii) complex possessing a monooxygenase-like catalytic function
From the themed collection: Nanozymes
Paper

Functionalized nanozyme with drug loading for enhanced tumour combination treatment of catalytic therapy and chemotherapy

We report the development of Zr/Ce-MOFs/DOX/MnO2 as a new nanozyme for enhanced combination catalytic therapy and chemotherapy of cancer in vitro and in vivo.

Graphical abstract: Functionalized nanozyme with drug loading for enhanced tumour combination treatment of catalytic therapy and chemotherapy
From the themed collection: Nanozymes
Open Access Paper

Dual functionality of ferrocene-based metallopolymers as radical scavengers and nanoparticle stabilizing agents

The surface of latex nanoparticles was functionalized with ferrocene-based metallopolymers to obtain an efficient radical scavenger composite with remarkable colloidal stability.

Graphical abstract: Dual functionality of ferrocene-based metallopolymers as radical scavengers and nanoparticle stabilizing agents
From the themed collection: Nanozymes
Paper

Light-activated carbon dot nanozyme with scandium for a highly efficient and pH-universal bio-nanozyme cascade colorimetric assay

We report the Sc3+-boosted photocatalytic oxidation of C-dots based on strong coordination and electron transfer for constructing a cascade colorimetric assay at broad pH.

Graphical abstract: Light-activated carbon dot nanozyme with scandium for a highly efficient and pH-universal bio-nanozyme cascade colorimetric assay
From the themed collection: Nanozymes
Paper

A porphyrin-MOF-based integrated nanozyme system for catalytic cascades and light-enhanced synergistic amplification of cellular oxidative stress

An integrated iron-porphyrin-MOF-based nanozyme composite named HGPF was constructed for the intracellular glucose-initiated catalytic oxidation cascades and light-enhanced generation of ROS, synergistically amplifying cellular oxidative stress.

Graphical abstract: A porphyrin-MOF-based integrated nanozyme system for catalytic cascades and light-enhanced synergistic amplification of cellular oxidative stress
From the themed collection: Nanozymes
Paper

Nanozyme-integrated microneedle patch for enhanced therapy of cutaneous squamous cell carcinoma by breaking the gap between H2O2 self-supplying chemodynamic therapy and photothermal therapy

A microneedle patch has been developed to bridge the gap between H2O2 self-supplying chemodynamic therapy and photothermal therapy, resulting in enhanced therapy of cutaneous squamous cell carcinoma.

Graphical abstract: Nanozyme-integrated microneedle patch for enhanced therapy of cutaneous squamous cell carcinoma by breaking the gap between H2O2 self-supplying chemodynamic therapy and photothermal therapy
From the themed collection: Microneedles
Paper

Reactive oxygen species-mediated CuRuOX@HA hybrid nanozymes for multidrug-resistant bacterial infections with synergistic photothermal therapy

This study prepared a ROS-mediated copper-ruthenium oxide (CuRuOX) hybrid nanozyme (CuRuOX@HA) modified with hyaluronic acid (HA).

Graphical abstract: Reactive oxygen species-mediated CuRuOX@HA hybrid nanozymes for multidrug-resistant bacterial infections with synergistic photothermal therapy
From the themed collection: Nanozymes
Paper

A dual-nanozyme-loaded black phosphorus multifunctional therapeutic platform for combined photothermal/photodynamic/starvation cancer therapy

Schematic diagram of the construction of AMGP and its application in the combination therapy of tumors.

Graphical abstract: A dual-nanozyme-loaded black phosphorus multifunctional therapeutic platform for combined photothermal/photodynamic/starvation cancer therapy
From the themed collection: Nanozymes
Paper

Single-layer HNb3O8 with strong and nearby Lewis and Brønsted acid sites boosts amide bond hydrolysis for urease mimicking

Single-layer HNb3O8 with strong and nearby Lewis and Brønsted acid sites mimicking urease can excellently catalyze amide bond hydrolysis. This material even outperforms urease in urea hydrolysis at 50 °C due to its high thermal stability.

Graphical abstract: Single-layer HNb3O8 with strong and nearby Lewis and Brønsted acid sites boosts amide bond hydrolysis for urease mimicking
From the themed collection: Nanozymes
Paper

Fe3N-decorated porous carbon frameworks from wheat flour with dual enzyme-mimicking activities for organic pollutant degradation

Fe3N decorated on porous carbon frameworks via a one-step pyrolysis exhibited outstanding dual enzyme-mimicking activities for organic pollutant degradation and excess H2O2 removal without consuming additional resources and energy.

Graphical abstract: Fe3N-decorated porous carbon frameworks from wheat flour with dual enzyme-mimicking activities for organic pollutant degradation
From the themed collection: Nanozymes
Paper

Nanozyme-catalyzed cascade reaction enables a highly sensitive detection of live bacteria

The Au@POM nanoparticles were facilely synthesized using a one-step method. The as-prepared Au@POMs have excellent GOx-like and HRP-like activities, allowing for fast cascade reactions and sensitive bacterial detections.

Graphical abstract: Nanozyme-catalyzed cascade reaction enables a highly sensitive detection of live bacteria
From the themed collection: Nanozymes
Paper

Comparison of the peroxidase activities of iron oxide nanozyme with DNAzyme and horseradish peroxidase

A systematic comparison of three catalysts with peroxidase and peroxidase-like activities revealed the trend of activity, stability and the effect of buffer and pH for the oxidation of TMB.

Graphical abstract: Comparison of the peroxidase activities of iron oxide nanozyme with DNAzyme and horseradish peroxidase
From the themed collection: Nanozymes
Paper

Visual evaluation of acetylcholinesterase inhibition by an easy-to-operate assay based on N-doped carbon nanozyme with high stability and oxidase-like activity

We propose an easy-to-operate nanozyme assay for the visual evaluation of AChE inhibition.

Graphical abstract: Visual evaluation of acetylcholinesterase inhibition by an easy-to-operate assay based on N-doped carbon nanozyme with high stability and oxidase-like activity
From the themed collection: Nanozymes
75 items - Showing page 1 of 2

About this collection

Nanozymes are nanomaterials with enzyme-like characteristics. They have been developed to address the limitations of natural enzymes and conventional artificial enzymes. Along with the significant advances in nanotechnology, biotechnology, catalysis science, and computational design, great progress has been achieved in the field of nanozymes since the discovery of peroxidase-like iron oxide nanozyme in 2007. Nanozymes have been explored for a variety of applications, ranging from biosensing and therapeutics to environmental protection and national security. To our knowledge, more than 400 laboratories from 35 countries are working on nanozymes. Notably, both the publications and citations on nanozymes have been growing rapidly, showing the enormous research interest from the field.

This themed collection on ‘Nanozymes’ is Guest Edited by Prof. Shaoqin Liu (Harbin Institute of Technology, China), Prof. Vincent Rotello (University of Massachusetts, USA), Prof. Asier Unciti-Broceta (University of Edinburgh, UK) and Prof. Hui Wei (Nanjing University, China) and highlights some of the recent progress in the field of nanozymes from across Journal of Materials Chemistry B and Nanoscale.

We hope that this special collection will not only accelerate the development of the nanozyme field, but also attract more researchers to explore the hidden characteristics of nanomaterials for broad applications.  Congratulations to all featured authors!

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