Themed collection Medicinal Inorganic Chemistry
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Medicinal inorganic chemistry: a web themed issue
Guest editors introduce this web collection celebrating current achievements and future perspectives in medicinal inorganic chemistry, including: metal-based diagnostics and therapeutics, mechanistic studies of metallotherapeutics, the role of metal ions and metal ion homeostasis in disease, chelation therapy, metalloprotein inhibitors, and metal ion sensing.
Chem. Commun., 2013,49, 5910-5911
https://doi.org/10.1039/C3CC90159A
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Exploration of the medical periodic table: towards new targets
Exploration of medicinal chemistry of the elements of the periodic table, and especially metals, offers the promise of new drugs and diagnostic agents with novel targets and new mechanisms of action.
Chem. Commun., 2013,49, 5106-5131
https://doi.org/10.1039/C3CC41143E
Tumour targeting with radiometals for diagnosis and therapy
This feature article highlights the field of metallic radionuclides in nuclear oncology for diagnosis with PET or SPECT and treatment with α, β−, or Auger electron therapy.
Chem. Commun., 2013,49, 4720-4739
https://doi.org/10.1039/C3CC41554F
The path for metal complexes to a DNA target
Recent results on a variety of transition metal complexes targeted to DNA are reviewed in order to illustrate many of the issues involved in new therapeutic design.
Chem. Commun., 2013,49, 3617-3630
https://doi.org/10.1039/C3CC00177F
Kinetics and thermodynamics of metal binding to the N-terminus of a human copper transporter, hCTR1
The N-terminus of hCTR1 was demonstrated to bind three Cu+ ions tightly (log K = 14.92) and reversibly via its Met-rich motifs.
Chem. Commun., 2013,49, 9134-9136
https://doi.org/10.1039/C3CC45360J
Zinc finger peptide cleavage by a dinuclear platinum compound
The platinum-assisted cleavage of the C-terminal HIV NCp7 zinc finger is a novel strategy to inactivate this important biological target.
Chem. Commun., 2013,49, 6986-6988
https://doi.org/10.1039/C3CC44219E
NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound
Simultaneous multi-element imaging using NanoSIMS provides information on the subcellular localisation of both metal and ligands inside tumour cells treated with 15N-labelled Pt drugs.
Chem. Commun., 2013,49, 6944-6946
https://doi.org/10.1039/C3CC42098A
Dioxygen mediated conversion of {Fe(NO)2}9 dinitrosyl iron complexes to Roussin's red esters
The reaction of S-bound {Fe(NO)2}9 dinitrosyl iron complexes with dioxygen results in the formation of Roussin's red esters and thiolate oxidation.
Chem. Commun., 2013,49, 5550-5552
https://doi.org/10.1039/C3CC40352A
Copper ligation to soluble oligomers of the English mutant of the amyloid-β peptide yields a linear Cu(I) site that is resistant to O2 oxidation
Copper coordination to soluble oligomers of the English (AβH(6)R) mutant of the amyloid-β peptide is probed.
Chem. Commun., 2013,49, 4797-4799
https://doi.org/10.1039/C3CC40326B
A comparative chemical–biological evaluation of titanium(IV) complexes with a salan or cyclopentadienyl ligand
The biological investigation of novel titanium(IV) complexes shows very interesting properties concerning their binding to biomolecules, cellular accumulation and intracellular distribution depending on the ligand system.
Chem. Commun., 2013,49, 4785-4787
https://doi.org/10.1039/C3CC38604J
A Pt(II)–Dip complex stabilizes parallel c-myc G-quadruplex
[Pt(Dip)2](PF6)2, prepared by the microwave irradiation method, achieves a selective stabilization towards parallel c-myc GQ via aromatic anchors on phenathroline ligands.
Chem. Commun., 2013,49, 4758-4760
https://doi.org/10.1039/C3CC40868J
Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide
Zinc alters the aggregation pathway of human islet amyloid polypeptide (hIAPP), an amyloidogenic peptide linked to type II diabetes, to favor nonfibrillar oligomers over amyloid fibers.
Chem. Commun., 2013,49, 3339-3341
https://doi.org/10.1039/C3CC40383A
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Organometallic anticancer complexes of lapachol : metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity
Organometallic lapachol complexes, in particular a Ru derivative, induce apoptosis in human tumour cell lines by a mode of action involving oxidative stress.
Chem. Commun., 2013,49, 3348-3350
https://doi.org/10.1039/C3CC40432C
Antagonism of a zinc metalloprotease using a unique metal-chelating scaffold: tropolones as inhibitors of P. aeruginosa elastase
Tropolone emerged from the screening of a chelator fragment library (CFL) as an inhibitor of the Zn2+-dependent virulence factor, Pseudomonas aeruginosa elastase (LasB).
Chem. Commun., 2013,49, 3197-3199
https://doi.org/10.1039/C3CC41191E
Detecting and delivering platinum anticancer drugs using fluorescent maghemite nanoparticles
Rhodamine-embedded maghemite nanoparticles provide a novel strategy for tracing and transporting platinum anticancer drugs in vitro and in vivo.
Chem. Commun., 2013,49, 2786-2788
https://doi.org/10.1039/C3CC39059D
A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders
Conversion of 1 to 2 results in enhanced antioxidant and radical scavenging capacity thus encouraging applications for neurological disorders such as Alzheimer's disease.
Chem. Commun., 2013,49, 2712-2714
https://doi.org/10.1039/C2CC36808K
Rapid and sensitive LC-MS approach to quantify non-radioactive transition metal impurities in metal radionuclides
A rapid and sensitive LC-MS approach for the quantification of non-radioactive metal contaminants present in metal radionuclide formulations was developed.
Chem. Commun., 2013,49, 2697-2699
https://doi.org/10.1039/C3CC39071C
Light uncages a copper complex to induce nonapoptotic cell death
The cytotoxicity of a copper complex increases in response to UV light, which triggers cleavage of the complex and causes extensive cytoplasmic vacuolization that is indicative of nonapoptotic cell death.
Chem. Commun., 2013,49, 2460-2462
https://doi.org/10.1039/C3CC38927H
Design of a platinum–acridine –endoxifen conjugate targeted at hormone -dependent breast cancer
A multifunctional breast cancer targeted conjugate was synthesized that combines features of an anti-estrogen and a DNA-directed platinating–intercalating hybrid agent.
Chem. Commun., 2013,49, 2415-2417
https://doi.org/10.1039/C3CC38957J
Antimicrobial metallopeptides with broad nuclease and ribonuclease activity
Metal complexed derivatives of antimicrobial peptides demonstrate enhanced antimicrobial activity against a variety of pathogenic bacteria and mediate irreversible cleavage of nucleic acids, suggesting a likely mechanism of action.
Chem. Commun., 2013,49, 2118-2120
https://doi.org/10.1039/C3CC38977D
Pt(II) compounds interplay with Cu(II) and Zn(II) coordination to the amyloid-β peptide has metal specific consequences on deleterious processes associated to Alzheimer's disease
A cyclometallated Pt complex able to interact specifically with the amyloid-β peptide, via the Glu11 and His13 side-chains, can preclude Zn induced aggregation of Aβ.
Chem. Commun., 2013,49, 2130-2132
https://doi.org/10.1039/C3CC38537J
About this collection
This web themed issue celebrates current achievements and future perspectives in the exciting field of medicinal inorganic chemistry, including, but not limited to: metal-based diagnostics, metal-based therapeutics, mechanistic studies of metallotherapeutics, the role of metal ions and metal ion homeostasis in disease, chelators of medicinal interest (i.e., chelation therapy), inhibitors of medically-relevant metalloproteins, and metal ion sensing.
The guest editors of the issue are Amy Barrios (University of Utah, Salt Lake City, USA), Seth Cohen (University of California, San Diego, USA), and Mi Hee Lim (University of Michigan, Ann Arbor, USA).
Articles in this web themed issue will be added below as soon as possible after they are published. Please return to this page frequently to see the collection grow