Issue 42, 2013
From the journal:

Chemical Communications

A comparative chemical–biological evaluation of titanium(iv) complexes with a salan or cyclopentadienyl ligand†

Julia Schur,a   Cesar M. Manna,b   Anthony Deally,c   Reinhard W. Köster,d   Matthias Tacke,c   Edit Y. Tshuvab  and  Ingo Ott*a  

* Corresponding authors

a Institute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Braunschweig, Germany
E-mail: ingo.ott@tu-bs.de
Tel: +49 5313912743

b Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
E-mail: edit.tshuva@mail.huji.ac.il
Tel: +972 26586084

c University College Dublin, UCD School of Chemistry and Chemical Biology, Belfield, Dublin 4, Ireland
E-mail: matthias.tacke@ucd.ie
Tel: +353 17168428

d Zoological Institute, Cell Physiology, Technische Universität Braunschweig, Braunschweig, Germany
E-mail: r.koester@tu-bs.de
Tel: +49 5313913230

Abstract

Titanium(IV) complexes with a salan or cyclopentadienyl ligand showed different biological behaviour concerning binding to biomolecules, cellular accumulation and intracellular distribution. Binding efficacy as well as trafficking on the cellular level are crucial parameters for their biological effects.

Graphical abstract: A comparative chemical–biological evaluation of titanium(iv) complexes with a salan or cyclopentadienyl ligand

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Article information

DOI
https://doi.org/10.1039/C3CC38604J
Article type
Communication
Submitted
30 nov 2012
Accepted
08 apr 2013
First published
09 apr 2013

Chem. Commun., 2013,49, 4785-4787

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A comparative chemical–biological evaluation of titanium(IV) complexes with a salan or cyclopentadienyl ligand

J. Schur, C. M. Manna, A. Deally, R. W. Köster, M. Tacke, E. Y. Tshuva and I. Ott, Chem. Commun., 2013, 49, 4785 DOI: 10.1039/C3CC38604J

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