Issue 21, 2013

Pt(ii) compounds interplay with Cu(ii) and Zn(ii) coordination to the amyloid-β peptide has metal specific consequences on deleterious processes associated to Alzheimer's disease

Abstract

Five Pt(II) complexes were tested for their ability to interfere in Cu(II) or Zn(II) coordination to the Aβ peptide. Two of them induce modifications of the Cu(II) sphere but not the associated Cu(Aβ) ROS production. In contrast, they do completely preclude Zn induced Aβ aggregation.

Graphical abstract: Pt(ii) compounds interplay with Cu(ii) and Zn(ii) coordination to the amyloid-β peptide has metal specific consequences on deleterious processes associated to Alzheimer's disease

Supplementary files

Article information

Article type
Communication
Submitted
27 nov 2012
Accepted
23 jan 2013
First published
23 jan 2013

Chem. Commun., 2013,49, 2130-2132

Pt(II) compounds interplay with Cu(II) and Zn(II) coordination to the amyloid-β peptide has metal specific consequences on deleterious processes associated to Alzheimer's disease

F. Collin, I. Sasaki, H. Eury, P. Faller and C. Hureau, Chem. Commun., 2013, 49, 2130 DOI: 10.1039/C3CC38537J

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