Issue 26, 2013

Rapid and sensitive LC-MS approach to quantify non-radioactive transition metal impurities in metal radionuclides

Abstract

A rapid and sensitive LC-MS approach for the quantification of non-radioactive metal contaminants present in metal radionuclide formulations was developed. Traditional 12C/1H and heavy stable isotope 13C/2H-labeled chelator–amino acid conjugates are used as chelating agents to quantify contaminating transition metals, allowing for determination of effective specific activity of radio-metals.

Graphical abstract: Rapid and sensitive LC-MS approach to quantify non-radioactive transition metal impurities in metal radionuclides

Supplementary files

Article information

Article type
Communication
Submitted
19 dec 2012
Accepted
13 feb 2013
First published
14 feb 2013

Chem. Commun., 2013,49, 2697-2699

Rapid and sensitive LC-MS approach to quantify non-radioactive transition metal impurities in metal radionuclides

D. Zeng and C. J. Anderson, Chem. Commun., 2013, 49, 2697 DOI: 10.1039/C3CC39071C

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