Themed collection 2024 Chemical Science HOT Article Collection
![](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/Ajax-GA-Loader.gif)
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Construction of axially chiral molecules enabled by photoinduced enantioselective reactions
An overview of the recent advances in the photoinduced construction of axially chiral compounds was presented.
Chem. Sci., 2024,15, 12636-12643
https://doi.org/10.1039/D4SC03766A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Detour to success: photoswitching via indirect excitation
Photoswitching via indirect excitation allows harnessing low-energy photons to control molecular configuration. Herein, the state of the art of the predominant indirect photoswitching methods is presented.
Chem. Sci., 2024,15, 11684-11698
https://doi.org/10.1039/D4SC02538E
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Opportunities and challenges for plastic depolymerization by biomimetic catalysis
This perspective highlights the challenges and opportunities in achieving sustainable plastic recycling under mild conditions by imitating the active sites and the substrate-binding clefts of enzymes.
Chem. Sci., 2024,15, 6200-6217
https://doi.org/10.1039/D4SC00070F
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Revisiting poly(vinyl chloride) reactivity in the context of chemical recycling
An overview of PVC functionalization through the lens of chemical recycling.
Chem. Sci., 2024,15, 5802-5813
https://doi.org/10.1039/D3SC06758K
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Connecting chemical worlds for a sustainable future
While chemistry has a role as the central science, other sciences are also central to solving the problems that lie ahead. To be more effective in this endeavor, we need to connect disciplines and break down the silos that artificially separate them.
Chem. Sci., 2024,15, 5056-5060
https://doi.org/10.1039/D3SC06815C
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Hybrid and composite materials of organic crystals
Combining organic crystals and polymers results in a new class of all-organic, lightweight, flexible materials with unprecedented mechanical robustness, resilience, and diversity in combination with other functional materials.
Chem. Sci., 2024,15, 2684-2696
https://doi.org/10.1039/D3SC06469G
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Copper–oxygen adducts: new trends in characterization and properties towards C–H activation
Recent progresses in Cu–oxygen adducts towards recalcitrant C–H activation are reviewed with focus on Cu metalloenzymes and bioinspired synthetic models, mono- to polynuclear complexes, working under homogeneous and heterogeneous catalytic conditions.
Chem. Sci., 2024,15, 10308-10349
https://doi.org/10.1039/D4SC01762E
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Adamantane-type clusters: compounds with a ubiquitous architecture but a wide variety of compositions and unexpected materials properties
Adamantane-type clusters exhibit a huge diversity of chemical compositions, structural details, and resulting properties.
Chem. Sci., 2024,15, 9438-9509
https://doi.org/10.1039/D4SC01136H
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Hard carbon for sodium-ion batteries: progress, strategies and future perspective
Recent progress of preparation approaches for HCs is systematically overviewed, with a special focus on the comparison between traditional fabrication methods and advanced strategies regarding their influence on performance.
Chem. Sci., 2024,15, 6244-6268
https://doi.org/10.1039/D4SC00734D
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
The status and challenging perspectives of 3D-printed micro-batteries
Recent advances and present status of 3D-printed micro-batteries with respect to the connection between printable materials and printing techniques, as well as the rational design considerations are summarized.
Chem. Sci., 2024,15, 5451-5481
https://doi.org/10.1039/D3SC06999K
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Recent advances in electrolyte molecular design for alkali metal batteries
In response to societal developments and the growing demand for high-energy-density battery systems, alkali metal batteries (AMBs) have emerged as promising candidates for next-generation energy storage.
Chem. Sci., 2024,15, 4238-4274
https://doi.org/10.1039/D3SC06650A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Computational insights into aqueous speciation of metal-oxide nanoclusters: an in-depth study of the Keggin phosphomolybdate
Herein, we present a new computational methodology that unlocks the prediction of the complex multi-species multi-equilibria processes involved in the formation of complex metal-oxo nanoclusters.
Chem. Sci., 2024, Advance Article
https://doi.org/10.1039/D4SC03282A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Two- and three-photon processes during photopolymerization in 3D laser printing
This study explores the mechanisms of photoactivation and radical formation during 3D laser printing using photoresists with a DETC photoinitiator. The role of DETC in high triplet states during radical polymerization is revealed.
Chem. Sci., 2024,15, 12695-12709
https://doi.org/10.1039/D4SC03527E
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Straightforward synthesis of complex polymeric architectures with ultra-high chain density
The application of trichloroacetyl isocyanate (TAI) adducts as initiators of copper-mediated reversible-deactivation radical polymerization (Cu-RDRP) unlocks straightforward access to complex polymeric architectures with ultra-high chain density.
Chem. Sci., 2024,15, 12739-12753
https://doi.org/10.1039/D4SC01739K
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Exploring the influence of H-bonding and ligand constraints on thiolate ligated non-heme iron mediated dioxygen activation
The kinetics study herein experimentally demonstrates that an inner-sphere ET mechanism is involved in the conversion of triplet O2 into a powerful oxidant by an RS–Fe complex. Hydrogen-bond donors are shown to destabilize the transition-state.
Chem. Sci., 2024,15, 12710-12720
https://doi.org/10.1039/D4SC02787F
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
C–H functionalization of 2-alkyl tryptamines: direct assembly of azepino[4,5-b]indoles and total synthesis of ngouniensines
The concise total synthesis of ngouniensines is reported, in which 2-Me-tryptamine undergoes sequential C–H functionalization with different aldehydes to afford the azepino[4,5-b]indole core and an exocyclic conjugated alkene, respectively.
Chem. Sci., 2024,15, 12732-12738
https://doi.org/10.1039/D4SC02802C
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Dynamically blocking leakage current in molecular tunneling junctions
Incorporating mixed flexible-rigid backbones into molecular junctions can dynamically block tunneling currents and enhance rectification.
Chem. Sci., 2024,15, 12721-12731
https://doi.org/10.1039/D4SC02829E
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
4f-Orbital mixing increases the magnetic susceptibility of Cp′3Eu
X-ray absorption spectroscopy and variable temperature magnetometry show evidence of 4f-orbital mixing in Cp′3Eu, which increases its magnetic susceptibility.
Chem. Sci., 2024,15, 12667-12675
https://doi.org/10.1039/D4SC01300J
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Trityl isocyanide as a general reagent for visible light mediated photoredox-catalyzed cyanations
Bench-stable trityl isocyanide enables the photoredox catalytic cyanation of carboxylic acids, alcohols and alkyl halides.
Chem. Sci., 2024, Advance Article
https://doi.org/10.1039/D4SC04199B
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Initiating a composite membrane with a localized high iodine concentration layer based on adduct chemistry to enable highly reversible zinc–iodine flow batteries
A cost-effective and high-performance composite membrane is developed by leveraging a localized high iodine concentration layer based on the adducts chemistry, where polyiodide shuttling can be suppressed with improved coulombic/energy efficiency.
Chem. Sci., 2024, Advance Article
https://doi.org/10.1039/D4SC04206A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Unnatural enzyme activation by a metal-responsive regulatory protein
A bifunctional molecule with binders for calmodulin (CaM) and glutathione S-transferases (GST) converts GST into a triggerable enzyme, whose activity is unnaturally regulated by CaM's conformational state and consequently, by calcium ions.
Chem. Sci., 2024, Advance Article
https://doi.org/10.1039/D4SC02635G
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Low thermal quenching of metal halide-based metal–organic framework phosphor for light-emitting diodes
A green MOF phosphor can maintain 84% of its initial emission intensity after being heated to 150 °C, exceeding several commercial inorganic phosphors.
Chem. Sci., 2024, Advance Article
https://doi.org/10.1039/D4SC04228J
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Quantifying near-symmetric molecular distortion using symmetry-coordinate structural decomposition
A new method for analyzing crystal structures of molecules distorted from their regular shape separates atom movements into symmetry modes so that molecular conformation of functional materials can be quantified and compared easily across databases.
Chem. Sci., 2024, Advance Article
https://doi.org/10.1039/D4SC01670J
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Gradual evolution of a homo-L-peptide world on homo-D-configured RNA and DNA
Nucleic acids with hypermodified nucleosides perform stereoselective RNA/DNA-mediated peptide coupling, followed by thermal release of the peptide, leading to temperature-driven one-pot cycles with gradual homochiral L-peptide enrichment.
Chem. Sci., 2024, Advance Article
https://doi.org/10.1039/D4SC03384A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Cu site differentiation in tetracopper(I) sulfide clusters enables biomimetic N2O reduction
Resonant X-ray diffraction measurements were used to examine Cu site differentiation within a Cu4S cluster that distorts its geometry to activate N2O, thus mimicking the behavior of the biological CuZ active site.
Chem. Sci., 2024, Advance Article
https://doi.org/10.1039/D4SC00701H
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Built-in electrophilic/nucleophilic domain of nitrogen-doped carbon nanofiber-confined Ni2P/Ni3N nanoparticles for efficient urea-containing water-splitting reactions
A built-in electrophilic/nucleophilic domain promoted the favorable adsorption of urea molecules on the surface/interface of heterogeneous Ni2P/Ni3N, reducing the energy barrier of the rate-determining step, and boosting urea electrolysis.
Chem. Sci., 2024, Advance Article
https://doi.org/10.1039/D4SC01862A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Intensified electrochemiluminescence and photoluminescence via supramolecular anion recognition interactions
Herein, intensified electrochemiluminescence (ECL) and photoluminescence (PL) via supramolecular anion recognition interactions are demonstrated. This great improvement is attributed to the restriction of intramolecular rotation upon anion coordination.
Chem. Sci., 2024,15, 12291-12300
https://doi.org/10.1039/D4SC03338H
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Reaction acceleration at the surface of a levitated droplet by vapor dosing from a partner droplet
Chemical reactions in millimeter-sized droplets can be accelerated by more than an order of magnitude.
Chem. Sci., 2024,15, 12277-12283
https://doi.org/10.1039/D4SC03528C
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Divergent total syntheses of pyrroloiminoquinone alkaloids enabled by the development of a Larock/Buchwald–Hartwig annulation/cyclization
Herein, we report a novel approach to pyrroloiminoquinones which was enabled by the development of a Larock/Buchwald–Hartwig annulation/cyclization cascade to rapidly construct the core, which was further elaborated to 5 of these natural products.
Chem. Sci., 2024,15, 12284-12290
https://doi.org/10.1039/D4SC02981J
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
δ-Bonding Modulates the Electronic Structure of Formally Divalent nd1 Rare Earth Arene Complexes
Chem. Sci., 2024, Accepted Manuscript
https://doi.org/10.1039/D4SC03005B
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Unraveling Non-Radiative Decay Channels of Exciplexes to Construct Efficient Red Emitters for Organic Light-Emitting Diodes
Chem. Sci., 2024, Accepted Manuscript
https://doi.org/10.1039/D4SC03667K
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Electronic energy transfer ionization in naphthalene–CO2 clusters reveals excited states of dry ice
Vacuum ultraviolet excitation of CO2 clusters and concomitant energy transfer to naphthalene leads to ionization which provides an understanding of excited state chemistry relevant to astrochemistry.
Chem. Sci., 2024, Advance Article
https://doi.org/10.1039/D4SC03561E
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Total synthesis, biological evaluation and biosynthetic re-evaluation of Illicium-derived neolignans
We report the total synthesis of seven Illicium-derived neolignans along with experimental evidence which unites homooligomers and apparent heterooligomers under a new biosynthesis proposal that features a single common precursor.
Chem. Sci., 2024,15, 11783-11793
https://doi.org/10.1039/D4SC03232B
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Molecular “backbone surgery” of electron-deficient heteroarenes based on dithienopyrrolobenzothiadiazole: conformation-dependent crystal structures and charge transport properties
A conformation engineering strategy is proposed to manipulate the crystal structure of electron deficient heteroarenes for superior n-type organic semiconductors with an electron mobility of 3.5 cm2 V−1 s−1.
Chem. Sci., 2024,15, 11761-11774
https://doi.org/10.1039/D4SC02794A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Deciphering charge transfer dynamics of a lead halide perovskite–nickel(II) complex for visible light photoredox C–N coupling
The introduction of Ni(dmgH)2 as a cocatalyst with CsPbBr3 quantum dots facilitates the activation of molecular oxygen to superoxide radical, initiating radical catalyzed C–N coupling between aldehyde and amine to form amide.
Chem. Sci., 2024, Advance Article
https://doi.org/10.1039/D4SC03023K
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Unleashing the potential of Li–O2 batteries with electronic modulation and lattice strain in pre-lithiated electrocatalysts
Electronic modulation and lattice strain in pre-lithiated electrocatalysts, lead to optimized Li–O intermediate adsorption and enhanced electron transfer for improved Li–O2 battery performance with high efficiency, longevity, and large capacity.
Chem. Sci., 2024, Advance Article
https://doi.org/10.1039/D4SC03242J
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Biomimetic engineering of a neuroinflammation-targeted MOF nanozyme scaffolded with photo-trigger released CO for the treatment of Alzheimer's disease
Alzheimer's disease (AD) is one of the most fatal and irreversible neurodegenerative diseases, which causes a huge emotional and financial burden on families and society.
Chem. Sci., 2024, Advance Article
https://doi.org/10.1039/D4SC02598A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
In situ electrosynthesis of quinone-based redox-active molecules coupling with high-purity hydrogen production
The asymmetric electrolysis cell concept was introduced to simultaneously produce quinone-based redox-active molecules and high-purity hydrogen gas.
Chem. Sci., 2024, Advance Article
https://doi.org/10.1039/D4SC03033H
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Divergent catalytic behaviors of assembled organogold(I) clusters derived from enyne cyclization
We achieve a dicarbanion-centered Au4 cluster and three assembled Au11 (net-like), Au28 (dumbbell-like), Au14 (closed) clusters. Spectral monitoring, kinetic and theoretical investigations reveal four structure-dependent distinct catalytic pathways.
Chem. Sci., 2024,15, 11311-11320
https://doi.org/10.1039/D4SC01618A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Synthesis of polyoxothiometalates through site-selective post-editing sulfurization of polyoxometalates
This work presents a direct site-selective oxygen–sulfur substitution method that enables transforming polyoxometalates [XW12O40]4− (X = Si, Ge) to Keggin-type polyoxothiometalates [XW12O28S12]4− using sulfurizing reagents in an organic solvent.
Chem. Sci., 2024,15, 11267-11271
https://doi.org/10.1039/D4SC02912G
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Kinetically controlled synthesis of low-strain disordered micro–nano high voltage spinel cathodes with exposed {111} facets
A micro–nano spherical spinel LiNi0.5Mn1.5O4 cathode material with highly exposed {111} facets has been designed. This unique structure could inhibit manganese dissolution, facilitate Li+ diffusion, and mitigate volumetric strain during cycling.
Chem. Sci., 2024,15, 11302-11310
https://doi.org/10.1039/D4SC02754J
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Accurate construction of monolayer, bilayer, sandwich bilayer, four-layer, multi-layer and chiral bilayer 2D pillararene-type supramolecular networks
2D monolayer, bilayer, sandwich bilayer, four-layer, multi-layer and chiral bilayer supramolecular networks were constructed from tetrapyridine functionalized pillararene and Co(II) and Cu(II) through controlling the temperature and guest induction.
Chem. Sci., 2024, Advance Article
https://doi.org/10.1039/D4SC03022B
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
A general graph neural network based implicit solvation model for organic molecules in water
Novel approach combining graph neural network and the physically motivated functional form of an implicit solvent model enables the description of solvation effects with the accuracy of explicit solvent simulations at a fraction of the time.
Chem. Sci., 2024,15, 10794-10802
https://doi.org/10.1039/D4SC02432J
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Nitrogen monoxide and calix[4]pyrrolato aluminate: structural constraint enabled NO dimerization
The dimerization of nitrogen monoxide (NO) is highly relevant in biochemical and environmental redox processes. Here, it is shown how structral constraint and element-ligand cooperativity can steer this reaction.
Chem. Sci., 2024,15, 10803-10809
https://doi.org/10.1039/D4SC02378A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Pathway-dependent supramolecular polymerization by planarity breaking
We introduce planarity breaking as a new design strategy for controlled supramolecular polymerization.
Chem. Sci., 2024,15, 10745-10752
https://doi.org/10.1039/D4SC02499K
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Key structural features to favour imines over hydrates in water: pyridoxal phosphate as a muse
The key structural features that aldehydes should present to favour imines over hydrates in water are investigated at different pD values. Sulfonate ortho-substituents remarkably stabilize iminium derivatives while disfavouring hydrate formation.
Chem. Sci., 2024,15, 10408-10415
https://doi.org/10.1039/D4SC02206H
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Structural-model-based genome mining can efficiently discover novel non-canonical terpene synthases hidden in genomes of diverse species
Non-canonical terpene synthases with primary sequences that are unrecognizable as canonical terpene synthases could be discovered through structural-model-based genome mining.
Chem. Sci., 2024,15, 10402-10407
https://doi.org/10.1039/D4SC01381F
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
A Pd-catalyzed route to carborane-fused boron heterocycles
A Pd-catalyzed cross-coupling system has been developed to achieve vicinal diamination of 9,10-dibromo-carborane with NH-heterocycles and anilines. These products can be further converted to carborane-fused six- and seven-membered heterocycles.
Chem. Sci., 2024,15, 10392-10401
https://doi.org/10.1039/D4SC02214A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Real-time investigation of reactive oxygen species and radicals evolved from operating Fe–N–C electrocatalysts during the ORR: potential dependence, impact on degradation, and structural comparisons
Hydroxyl radical and hydrogen peroxide are implicated in the poor stability of Fe–N–C catalysts. We use SECM to detect these transient species in real time to evaluate their possible sources and relationship to stability.
Chem. Sci., 2024,15, 10036-10045
https://doi.org/10.1039/D4SC01553C
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
A strategy for the controllable generation of organic superbases from benchtop-stable salts
Benchtop-stable organic superbase (SB) carboxylate salts, when paired with an epoxide in situ, controllably generate netural superbases for reaction applications.
Chem. Sci., 2024,15, 10018-10026
https://doi.org/10.1039/D4SC02524E
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
High-efficiency color-tunable ultralong room-temperature phosphorescence from organic–inorganic metal halides via synergistic inter/intramolecular interactions
A high-efficiency, color-tunable ultralong RTP system based on metal-halide hybrids has been developed, which shows forward-looking application prospects in the fields of information encryption, anti-counterfeiting and dynamic optical data storage.
Chem. Sci., 2024,15, 10046-10055
https://doi.org/10.1039/D4SC01630K
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Site-selective S-gem-difluoroallylation of unprotected peptides with 3,3-difluoroallyl sulfonium salts
Bench-stable 3,3-difluoroallyl sulfonium salts proved to be versatile fluoroalkylating reagents for site-selective S-gem-difluoroallylation of cysteine residues in unprotected peptides. The newly added functional groups are poised for ligation.
Chem. Sci., 2024,15, 10002-10009
https://doi.org/10.1039/D4SC02681K
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Facile synthesis of a hydrazone-based zinc(II) complex for ferroptosis-augmented sonodynamic therapy
This work reports a facilely synthesized zinc(II) complex based on a hydrazone ligand for ferroptosis-augmented sonodynamic therapy.
Chem. Sci., 2024,15, 10027-10035
https://doi.org/10.1039/D4SC02102A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Acridine photocatalysis enables tricomponent direct decarboxylative amine construction
Diverse amines and amino acids are now readily accessed from carboxylic acids, aldehydes, and amine precursors in a direct decarboxylative reaction enabled by a homogeneous triple catalytic system based on acridine photocatalysis.
Chem. Sci., 2024,15, 9582-9590
https://doi.org/10.1039/D4SC02356K
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Cross-linked K0.5MnO2 nanoflower composites for high rate and low overpotential Li–CO2 batteries
The synergistic effect between ultra-thin K0.5MnO2 nanoflowers and CNTs effectively promotes the nucleation and charging decomposition of Li2CO3, achieving low overpotential and high average energy efficiency as a Li–CO2 cathode.
Chem. Sci., 2024,15, 9591-9598
https://doi.org/10.1039/D4SC01799D
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Mechanistic investigations of the Fe(II) mediated synthesis of squaraines
In situ monitoring and reaction sampling (IR, NMR, EPR, Mössbauer spectroscopy) and structural characterisation of isolable species allows detailed mechanistic insight into the scission/homologation of CO by two-coordinate iron terphenyl complexes.
Chem. Sci., 2024,15, 9599-9611
https://doi.org/10.1039/D4SC01286K
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Copper-catalysed perarylation of cyclopentadiene: synthesis of hexaarylcyclopentadienes
The development of a copper-catalysed direct hexaarylation of cyclopentadiene under microwave activation allowed the synthesis of a family of unprecedented hexaarylcyclopentadienes.
Chem. Sci., 2024,15, 9127-9137
https://doi.org/10.1039/D4SC02458C
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Nanoscale and chiral metal–organic frameworks for asymmetric reactions in water: bridging Lewis acid catalysis and biological systems
A new chiral UiO-type MOF with scandium tris(dodecyl sulfate) showed superior catalytic performance to the usual micellar catalysis in the presence of proteins, demonstrating the ability to prevent active Lewis acid sites from mortiferous deactivation.
Chem. Sci., 2024,15, 9120-9126
https://doi.org/10.1039/D4SC01343C
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Achieving pure room temperature phosphorescence (RTP) in phenoselenazine-based organic emitters through synergism among heavy atom effect, enhanced n → π* transitions and magnified electron coupling by the A–D–A molecular configuration
Synergism among heavy atom effect, enhanced n → π* transitions and magnified electron coupling to promote pure RTP emission.
Chem. Sci., 2024,15, 9112-9119
https://doi.org/10.1039/D4SC01200C
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Highly acidic N-triflylphosphoramides as chiral Brønsted acid catalysts: the effect of weak hydrogen bonds and multiple acceptors on complex structures and aggregation
An in-depth analysis including NMR-spectroscopy at 180 K and computer simulations suggests an OHN hydrogen bond between the phosphoramide oxygen and the imine instead of the mostly proposed NHN H-bond in binary NTPA/imine complexes.
Chem. Sci., 2024,15, 9104-9111
https://doi.org/10.1039/D4SC01939C
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Neutral inverse-sandwich rare-earth metal complexes of the benzene tetraanion
Neutral inverse-sandwich rare-earth metal complexes of the parent benzene tetraanion with an [M3+–(C6H6)4−–M3+] core electronic structure were synthesized and characterized. They behave as a four-electron reductant to reduce unsaturated substrates.
Chem. Sci., 2024,15, 8740-8749
https://doi.org/10.1039/D4SC02491E
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
β-Terrecyclene synthase constructs the quadrane backbone in terrecyclic acid biosynthesis
The construction of a quadrane scaffold by β-terrecyclene synthase via Coates' route is demonstrated through mutagenesis and isotopically sensitive branching studies. Subsequent enzymatic modifications convert β-terrecyclene into terrecyclic acid.
Chem. Sci., 2024,15, 8750-8755
https://doi.org/10.1039/D4SC01208A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Tricyclononenes and tricyclononadienes as efficient monomers for controlled ROMP: understanding structure–propagation rate relationships and enabling facile post-polymerization modification
A tricyclononene and tricyclononadiene monomer library is studied experimentally and computationally to deepen understanding of structure propagation rate relationships in ROMP. A novel poly(tricyclononadiene) post-ROMP functionalization is explored.
Chem. Sci., 2024,15, 8334-8345
https://doi.org/10.1039/D4SC01986E
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Visualizing partial solvation at the air–water interface
To understand the solvation environment at the air–water interface, we use an azide vibrational reporter. The probe is sensitive to hydrogen bonding and electrostatics of the interface.
Chem. Sci., 2024,15, 8346-8354
https://doi.org/10.1039/D4SC01311E
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Azole reagents enabled ligation of peptide acyl pyrazoles for chemical protein synthesis
A novel strategy is herein introduced which utilizes azole additives to activate the weak acyl donor peptidyl N-acyl pyrazole, and thereby enables its direct ligation to an N-terminal cysteine peptide for efficient chemical protein synthesis.
Chem. Sci., 2024,15, 7965-7974
https://doi.org/10.1039/D3SC06697E
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Highly intense NIR emissive Cu4Pt2 bimetallic clusters featuring Pt(I)–Cu4–Pt(I) sandwich kernel
NIR phosphorescent Cu–Pt bimetallic clusters have been synthesized with solid-state quantum yield (QY) of up to 36.7%. Ligand effects enhances emission intensity and modulates emission wavelength via intra- and inter-molecular interactions.
Chem. Sci., 2024,15, 7552-7559
https://doi.org/10.1039/D4SC01022A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
Continuous flow synthesis and post-synthetic conversion of single-crystalline covalent organic frameworks
Single-crystalline 2D covalent organic frameworks were synthesized in flow with laboratory scale rates of more than 1 g h−1.
Chem. Sci., 2024,15, 7545-7551
https://doi.org/10.1039/D4SC01128G
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
A high-resolution structural characterization and physicochemical study of how a peptoid binds to an oncoprotein MDM2
How a peptoid binds to a protein was revealed by a co-crystal structure and systematic physicochemical studies.
Chem. Sci., 2024,15, 7051-7060
https://doi.org/10.1039/D4SC01540A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
A dynamic cascade DNA nanocomplex to synergistically disrupt the pyroptosis checkpoint and relieve tumor hypoxia for efficient pyroptosis cancer therapy
A DNA nanocomplex with cascade DNAzymes, promoter-like ZnO2–Mn nanozymes and intercalated photosensitizers was designed to synergistically disrupt autophagy and relieve tumor hypoxia for efficient pyroptosis therapy.
Chem. Sci., 2024,15, 7079-7091
https://doi.org/10.1039/D4SC01147C
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.146/content/NewImages/open-access-icon-orange.png)
A tin analogue of propadiene with cumulated C
Sn double bonds
The first stable linear 2-stannapropadiene has been synthesized. The inert-pair effect favors Sn2+, but silyl substituents can counter it, enabling the isolation of 2-stannapropadiene with a Sn4+.
Chem. Sci., 2024,15, 7072-7078
https://doi.org/10.1039/D4SC00093E
About this collection
This on-going web collection showcases all of the HOT Chemical Science articles published in 2024, as recommended by referees. Congratulations to all of the authors whose articles are featured.