Collaboration, competition and publication in toxicology: views of British Toxicology Society members
BTS members offer their opinions and interesting suggestions for improvement around resourcing, collaboration, competition, infrastructure and peer review in toxicology.
New models for the time dependent toxicity of individual and combined toxicants
A new model for combination effects gives descriptions of additivity, independence, synergy and antagonism and explains the multiple shapes of isoboles.
In silico prediction of chemical aquatic toxicity for marine crustaceans via machine learning
Six machine learning methods combined with descriptors or fingerprints were employed to predict chemical toxicity on marine crustaceans.
Distribution of toxicity values across different species and modes of action of pesticides from PESTIMEP and PPDB databases
Pesticides classified by mode of action as a source of predictive models of toxicity.
PM2.5 induced neurodegenerative-like changes in mice and the antagonistic effects of vitamin E
After PM2.5 exposure, ND-like changes were induced through oxidative stress and inflammation, Vit E could antagonise the effects.
A simple model to solve a complex drug toxicity problem
DTI redefines drug toxicity, identifies hepatotoxic drugs, gives mechanistic insights, predicts clinical outcomes and has potential use as a screening tool.
Clusterin increases mitochondrial respiratory chain complex I activity and protects against hexavalent chromium-induced cytotoxicity in L-02 hepatocytes
Previous evidence revealed significant elevated liver cancer mortality in the areas where water was contaminated with hexavalent chromium [Cr(VI)], which highlighted that we should pay more attention to Cr(VI)-induced cytotoxicity in hepatocytes.
Exploring the binding interaction between copper ions and Candida rugosa lipase
Copper ions enter the central group of the catalytic center of CRL and bind with CRL, resulting in a conformational change of the lipase. This in turn causes an increase in the enzyme activity.
Mitochondrial toxicity induced by a thiourea gold(I) complex: mitochondrial permeability transition and respiratory deficit
Gold(I) complexes have been widely used as antibacterial and antitumor agents for their excellent biological activities.
Ameliorative effects of quercetin against bisphenol A-caused oxidative stress in human erythrocytes: an in vitro and in silico study
Bisphenol A (BPA) is an endocrine disruptor of xenobiotic type, mainly used for the production of polycarbonate plastic, epoxy resins and non-polymer additives.
Surface functional groups affect CdTe QDs behavior at mitochondrial level
CdTe QDs functionalized with different groups showed different effects on mitochondrial membrane fluidity.
A 3D human lung-on-a-chip model for nanotoxicity testing
The prevalent application of nanoparticles (NPs) has drawn intense concerns about their impact on the environment and human health.
Deficit in the epidermal barrier induces toxicity and translocation of PEG modified graphene oxide in nematodes
Our data provide the molecular basis for the role of epidermal barrier against toxicity and translocation of nanomaterials in organisms.
The mitochondrial pathway is involved in sodium fluoride (NaF)-induced renal apoptosis in mice
The objective of the present study was to explore the molecular mechanism of apoptosis induced by sodium fluoride (NaF) in the mouse kidney by using the methods of flow cytometry, quantitative real-time polymerase chain reaction (qRT-PCR), western blotting, and experimental pathology.
Hemolytic and cellular toxicology of a sulfanilamide-based nonionic surfactant: a niosomal carrier for hydrophobic drugs
Sulfanilamide based nonionic surfactant can self-assemble into haemocompatible and non-toxic niosomes that are promising for drug delivery.
Effect of the calcination process on CdO–ZnO nanocomposites by a honey-assisted combustion method for antimicrobial performance
This work reports on honey as a combustion agent of CdO : ZnO nanocomposites and the effects of further annealing on their structural, optical, morphological, elemental, electrical and antimicrobial properties are investigated.
Correlation of the cytotoxic effects of cationic lipids with their headgroups
As effective non-viral vectors of gene therapy, cationic lipids still have the problem of toxicity, which has become one of the main bottlenecks for their applications.
Amino-PAHs activated Nrf2/ARE anti-oxidative defense system and promoted inflammatory responses: the regulation of PI3K/Akt pathway
The amino polycyclic aromatic hydrocarbons (amino-PAHs) were frequently detected in PM2.5, and it was suggested that they contributed to the harmful health effects associated with PM2.5.
Individual heavy metal exposure and birth outcomes in Shenqiu county along the Huai River Basin in China
Exposure to heavy metals during pregnancy is an important risk factor for adverse birth outcomes.
About this collection
This themed collection features articles published in Toxicology Research marked as HOT by the handling editor or as recommended by referees. Congratulations to all the authors whose articles are featured.