Themed collection CSC100: Celebrating Canadian Chemistry
The synthesis, stability and catalytic reactivity of borocations are described in the context of their reaction in frustrated Lewis pair-type processes.
Unravelling the mysteries of sub-second biochemical processes using time-resolved mass spectrometry
Many important chemical and biochemical phenomena proceed on sub-second time scales.
Pathogen inactivation of cruciferous phytoalexins: detoxification reactions, enzymes and inhibitors
This review covers the detoxification pathways of cruciferous phytoalexins, the corresponding detoxifying enzymes and their natural and synthetic inhibitors. Paldoxins are examined as a potentially sustainable strategy to control plant pathogenic fungi.
Methods for preparing DNA-functionalized gold nanoparticles, a key reagent of bioanalytical chemistry
Attaching DNA to gold nanoparticles (AuNPs) enables a suite of analytical and nanotechnology applications, yet the conjugation reaction itself manifests many interesting concepts in fundamental colloidal and interface sciences.
Aerobic granulation for future wastewater treatment technology: challenges ahead
Aerobic granules were discovered around 20 years back.
Azaborines: synthesis and use in the generation of stabilized boron-substituted carbocations
A formal N-heterocyclic carbene insertion into the B–H bond of 9-BBN followed by a ring expansion reaction is reported. NHC-9-BBN adducts were reacted in one or two steps to give the corresponding di- or triazaborines. Hydride abstraction of selected species with [Ph3C]+ is facile, giving rise to 6π-aromatic cations with Lewis acidity comparable to Lewis acids commonly employed in frustrated Lewis pairs.
o-Phthalaldehyde catalyzed hydrolysis of organophosphinic amides and other P(O)–NH containing compounds
Organocatalytic hydrolysis: o-Phthalaldehyde induces electrophilic activation in a variety of P(O)–NH compounds, allowing mild hydrolyses.
Mixed Cu(I)/Au(I) coordination polymers as reversible turn-on vapoluminescent sensors for volatile thioethers
Cu(I)-doping transforms an inactive Cu(I)/Au(I) coordination polymer into an emissive, reversible solid state sensor for dimethyl- and diethyl sulphide.
Crystal structure of Zn(ZnCl4)2(Cho)2: the transformation of ions to neutral species in a deep eutectic system
The ions of the ZnCl2/choline chloride deep eutectic system form a neutral complex by coordination to a central metal ion.
Facile synthesis of dendron-branched silicone polymers
Monofunctional dendritic silicone branches were created from hydro- and alkoxysilanes using the Piers–Rubinsztajn reaction. Monofunctional dendritic silicone branches were added to linear polymers with varied branch frequency, density and backbone molecular weight. Viscosities of the polymers increased with branch frequency to a maximum beyond which the viscosity decreased.
Revisiting the Juliá–Colonna enantioselective epoxidation: supramolecular catalysis in water
With only water as solvent, poly-L-leucine serves as supramolecular catalyst for the epoxidation of α,β-unsaturated ketones.
Schiff base thorium(IV) and uranium(IV) chloro complexes: synthesis, substitution and oxidation chemistry
Schiff base chloro complexes of U(IV) and Th(IV) are prepared and provide access to rare pseudo trans diazide species, and a facile pathway to uranyl complexes through oxidation with NaNO2.
Atom economical synthesis of N-alkylbenzamides via the iron(III) sulfate catalyzed rearrangement of 2-alkyl-3-aryloxaziridines in water and in the presence of a surfactant
A green preparation of N-alkylbenzamides involves synthesis of 2-alkyl-3-aryloxaziridines from N-alkylamines and benzaldehydes followed by iron(III) sulfate catalyzed rearrangement to the corresponding amides in water and in the presence of sodium dodecyl sulfate.
Phosphine–imine and –enamido ligands for acceptorless dehydrogenation catalysis
Ruthenium complexes with phosphine–enamido (blue) and phosphine–imine (red) ligands are both active toward acceptorless dehydrogenation reactions.
Carbohydrates as efficient catalysts for the hydration of α-amino nitriles
A general procedure for the alkaline hydration of α-amino nitriles has been developed using formaldehyde as catalyst.
Tailored theranostic apolipoprotein E3 porphyrin-lipid nanoparticles target glioblastoma
Size-controlled discoidal and cholesteryl oleated-loaded spherical, intrinsically multimodal porphyrin-lipid nanoparticles targeted glioblastoma via apoE3 and LDLR.
Reversible mechanical protection: building a 3D “suit” around a T-shaped benzimidazole axle
A benzimidazole molecule can be protected from deprotonation with strong base by converting into a suitane – a type of 3D mechanically interlocked molecule. Utilising a combination of ring-closing and ring-opening metathesis, the wearing of the protective “suit” can be made reversible.
Quantifying the efficiency of CO2 capture by Lewis pairs
A microfluidic strategy is used to assess the relative efficiency and thermodynamic parameters of CO2 binding by three Lewis acid/base combinations.
The development and mechanistic investigation of a palladium-catalyzed 1,3-arylfluorination of chromenes
A mild palladium-catalyzed ligand-controlled regioselective 1,3-arylfluorination of 2[H]-chromenes has been developed.
Design of biomimetic substrates for long-term maintenance of alveolar epithelial cells
There is a need to establish in vitro lung alveolar epithelial culture models to better understand the fundamental biological mechanisms that drive lung diseases.
C–H nickellation of phenol-derived phosphinites: regioselectivity and structures of cyclonickellated complexes
Cyclonickellation of aryl phosphinites derived from substituted phenols is regioselective: high sensitivity to sterics favors nickellation at the less hindered C–H.
Preparation of tetrazine-containing [2 + 1] complexes of 99mTc and in vivo targeting using bioorthogonal inverse electron demand Diels–Alder chemistry
A new 99mTc-labelled tetrazine for targeted imaging using bioorthogonal chemistry was developed and evaluated in vivo using a trans-cyclooctene derived bisphosphonate targeting regions of high bone turnover and bone lesions.
Rare earth elements in freshwater, marine, and terrestrial ecosystems in the eastern Canadian Arctic
Rare earth elements show consistent bioaccumulation patterns yet limited biomagnification in remote northern ecosystems.
Accurate and rapid organic detection by eliminating hysteresis in bioanode sensor applications
Bioanode sensors utilizing exoelectrogenic bacteria can be used for real-time and in situ assessment of water quality.
Synthesis of bis(trithio)phosphines by oxidative transfer of phosphorus(I)
We report the oxidative transfer of the phosphorus(I) centre in [PIdppe][Br] to tetrathiocin and disulfide ligands. Characterization of the resulting bis(trithio)phosphines and mechanistic insight into the formation of these products is provided.
Polylactic acid macromonomer radical propagation kinetics and degradation behaviour
Polylactic acid (PLA) macromonomer radical homopropagation rate coefficients are evaluated as a function of average macromonomer chain length. Hydrolysis studies of nanoparticles (NP) produced from PLA macromonomers demonstrate the importance of end-group functionality on NP degradation time.
Extracting structural trends from systematic variation of phosphonate/phosphonate monoester coordination polymers
Systematic variation of ligand geometry and ester size shows that dimensionality of barium phosphonate/phosphonate ester structures can be truncated by either route.
Gas chromatography and diode array detection for the direct measurement of carbon disulfide in challenging matrices
A fast and reliable gas chromatographic technique for the direct measurement of carbon disulfide at the parts-per-billion level is introduced.
Dehydrogenation of cyclic amines by a coordinatively unsaturated Cp*Ir(III) phosphoramidate complex
The reaction of a Cp*Ir(III) phosphoramidate complex with secondary amines gives amine, imine-bound Cp*Ir(III) hydride complexes resulting from amine dehydrogenation.
N-annulated perylene diimide dimers: the effect of thiophene bridges on physical, electronic, optical, and photovoltaic properties
In this work, we report on the synthesis, characterization, and photovoltaic properties of two new N-annulated PDI derivatives connected with one (M1) or two (M2) thiophene bridging units and directly compare to a twisted PDI dimer with no thiophene units (tPDI-Hex).
Ultra-low fouling methylimidazolium modified surfaces for the detection of HER2 in breast cancer cell lysates
We synthesized novel ultra-low fouling ionic liquids and demonstrated their use with surface plasmon resonance (SPR) sensing for the analysis of HER2 in breast cancer cell lysates.
Effects of freeze–thawing cycles on desorption behaviors of PAH-contaminated soil in the presence of a biosurfactant: a case study in western Canada
The combined effects of freeze–thawing cycles and surfactant can inhibit the sequestration of phenanthrene in soil.
Investigation of mechanisms involved in postprandial glycemia and insulinemia attenuation with dietary fibre consumption
This work examines the mechanisms involved in the attenuation of postprandial glycemic and insulinemic responses associated with soluble dietary fibre (SDF) consumption.
Mass transfer and convection effects in small-scale catalytic hydrogenation
The reaction rate of rhodium-catalyzed hydrogenation of alkynes was shown to be strongly influenced by the transfer of the hydrogen gas into the solution and stirring in the solution.
Microfluidic analysis of red blood cell deformability as a means to assess hemin-induced oxidative stress resulting from Plasmodium falciparum intraerythrocytic parasitism
We assessed the effect of free hemin on the deformability of bystander red blood cells using the multiplexed fluidic plunger microfluidic device.
Transformations of silver nanoparticles in wastewater effluents: links to Ag bioavailability
Physicochemical modifications of silver nanoparticles in wastewaters determine their bioavailability to Chlamydomonas reinhardtii.
Ni and Cu-catalyzed one pot synthesis of unsymmetrical 1,3-di(hetero)aryl-1H-indazoles from hydrazine, o-chloro (hetero)benzophenones, and (hetero)aryl bromides
A new nickel-catalyzed cyclization of ortho-chlorobenzophenone hydrazones, to afford 3-aryl-1H-indazoles, is applied in a one-pot synthesis of 1,3-diaryl-1H-indazoles.
Applying direct heteroarylation synthesis to evaluate organic dyes as the core component in PDI-based molecular materials for fullerene-free organic solar cells
A streamlined synthetic approach to easily access complex pi-conjugated molecular materials.
A field-deployed surface plasmon resonance (SPR) sensor for RDX quantification in environmental waters
A field-deployable surface plasmon resonance (SPR) sensor is reported for the detection RDX at ppb concentration in environmental samples.
High pH instability of quaternary ammonium surfactant coatings in capillary electrophoresis
Stability of cationic surfactant coatings at moderate to high pH depends on the aggregate structure on the surface of the silica capillary.
Utility of iron nanoparticles and a solution-phase iron species for the N-demethylation of alkaloids
N-Demethylation of selected N-methylalkaloids using a modified Polonovski reaction can be accomplished employing nanoscale zero-valent iron, nZVI, in isopropanol.
Real-time HPLC-MS reaction progress monitoring using an automated analytical platform
Automated sampling and in-line dilution allows both homogeneous and heterogeneous reactions to be easily profiled by real-time HPLC-MS.
Generation of cocrystals of Tavaborole (AN2690): opportunities for boron-containing APIs
Cocrystals of the FDA-approved boron-containing API Tavaborole (AN2690) were obtained through solvent evaporation with coformers functionalized with 4-pyridyl groups.
Thermal scribing to prototype plastic microfluidic devices, applied to study the formation of neutrophil extracellular traps
Plastic microfluidic devices can be rapidly and inexpensively prototyped “on the fly”, for cell culture experiments in which hydrophobic small molecules play an important role.
Microscopic evaluation of aqueous two-phase system emulsion characteristics enables rapid determination of critical polymer concentrations for solution micropatterning
A simple technique is presented to identify phase-transitions in polymeric aqueous two-phase systems.
Ultrasmall PbS quantum dots: a facile and greener synthetic route and their high performance in luminescent solar concentrators
Tributylphosphine-assisted greener synthesis of ultrasmall PbS quantum dots and their high performance in luminescent solar concentrator application.
Multiferroic Bi2FeCrO6 based p–i–n heterojunction photovoltaic devices
The p–i–n heterojunction devices based on intrinsic absorber multiferroic Bi2FeCrO6 sandwiched between p-type NiO and n-type Nb-doped SrTiO3 were demonstrated.
Thermodynamic cycles of the alkali metal–ligand complexes central to electride formation
Alkali metal–ligand complexes are the building blocks of the exotic organic alkalide and electride materials.
Body burdens, sources and interrelations of selected toxic and essential elements among the nine Cree First Nations of Eeyou Istchee, James Bay region of northern Quebec, Canada
Multi-media biomonitoring study of body burdens and potential sources of 11 elements in 9 Cree communities in northern Quebec (Canada).
High-affinity metal binding by the Escherichia coli [NiFe]-hydrogenase accessory protein HypB is selectively modulated by SlyD
SlyD activates the release of nickel and blocks the release of zinc from the high-affinity metal site of HypB.
Sn–Bi–Sb alloys as anode materials for sodium ion batteries
The cycling stability of Sb-based anodes for sodium-ion batteries can be greatly improved by adding Sn and Bi atoms in a substitutional solid solution with the host Sb lattice.
A simplified approach in flow controlled multi-dimensional gas chromatography
We introduce a simple and reliable approach for practicing flow controlled multi-dimensional gas chromatography.
Tunnelling and barrier-less motions in the 2-fluoroethanol–water complex: a rotational spectroscopic and ab initio study
Rotational spectrum of 2-fluoroethanol–water reveals interesting water and methyl internal rotation tunneling and barrier-less motions in the hydrogen-bonded complex.
Covering the optical spectrum through collective rare-earth doping of NaGdF4 nanoparticles: 806 and 980 nm excitation routes
Sensitization of numerous emission bands (from ultraviolet to near-infrared) in rare-earth doped multilayered nanoparticles: 806 versus 980 nm excitation.
Understanding particle formation in surfactant-free waterborne coatings prepared by emulsification of pre-formed polymers
Concern for the environment has been driving major changes in the coatings industry.
Synthesis of oxazolidinones: rhodium-catalyzed C–H amination of N-mesyloxycarbamates
N-Mesyloxycarbamates undergo intramolecular C–H amination reactions to afford oxazolidinones in good to excellent yields in the presence of rhodium(II) carboxylate catalysts.
Application of the boron center for the design of a covalently bonded closely spaced triad of porphyrin-fullerene mediated by dipyrromethane
Charge separation stabilization is achieved by placing porphyrin and C60 at the two ends of central BODIPY.
Interactions of Hg(II) with oligonucleotides having thymine–thymine mispairs. Optimization of an impedimetric Hg(II) sensor
The present work describes the effect of the number of thymine–thymine mispairs in single strand DNA probes on Hg(II) interactions and further to develop a highly sensitive DNA based impedimetric sensor for Hg(II) detection.
Phosphorescent platinum(II) complexes bearing pentafluorosulfanyl substituted cyclometalating ligands
The first examples of phosphorescent platinum(II) complexes bearing pentafluorosulfanyl (–SF5) substituted cyclometalating ligands (C^N) are reported.
Determination of europium isotope ratios in natural waters by MC-ICP-MS
An analytical protocol for the accurate and precise determination of the europium isotope ratio in low level natural waters is presented for the first time by using multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS) with a single-step column separation with di(2-ethylhexyl) orthophosphoric acid (HDEHP) resin.
Umbrella sampling molecular dynamics simulations reveal concerted ion movement through G-quadruplex DNA channels
We have applied the umbrella sampling (US) method in all-atom molecular dynamics (MD) simulations to obtain potential of mean force (PMF) profiles for ion transport through three representative G-quadruplex DNA channels: [d(TG4T)]4, [d(G3T4G4)]2, and d[G4(T4G4)3].
[HL2][P(1,2-O2C6Cl4)3] (L = THF, DMF): Brønsted acid initiators for the polymerization of n-butyl vinyl ether and p-methoxystyrene
The development of solid, weighable Brønsted acids featuring the hexacoordinated phosphorous(V) anion [TRISPHAT]− are reported.
One-step formation of dihydrofuranoindoline cores promoted by a hypervalent iodine reagent
Treatment of aniline derivatives in the presence of a hypervalent iodine reagent and furan produces dihydrofuranoindoline cores in one step.
2D Supramolecular networks of dibenzonitrilediacetylene on Ag(111) stabilized by intermolecular hydrogen bonding
Hydrogen bonding controls the intermolecular distances in supramolecular networks – a platform to design molecular patterns at surfaces/interfaces.
Large d–d luminescence energy variations in square-planar bis(dithiocarbamate) platinum(II) and palladium(II) complexes with near-identical MS4 motifs: a variable-pressure study
A surprising variation of luminescence maxima occurs for crystalline dithiocarbamate platinum(II) complexes with very similar square-planar coordination geometries but different peripheral substituents R, R′.
Preparing artificial latexes using a switchable hydrophilicity solvent
Artificial latexes of poly(butyl methacrylate) (PBMA), natural rubber, and other polymers were separately prepared from the bulk polymer using the CO2-responsive switchable hydrophilicity solvent N,N-dicyclohexylmethylamine (Cy2NMe) with the help of CO2.
Effect of gold nanoparticles on extracellular nutrient-cycling enzyme activity and bacterial community in soil slurries: role of nanoparticle size and surface coating
Engineered nanoparticles such as gold that are considered to be relatively chemically inert can influence soil enzyme activities and the composition of microbial communities that play an important role in nutrient cycling and soil health.
Optimized synthesis of π-extended squaraine dyes relevant to organic electronics by direct (hetero)arylation and Sonogashira coupling reactions
This study reports on the synthesis and characterization of four molecular π-extended squaraine compounds relevant to the field of organic electronics.
Thermochemical CO2 splitting using double perovskite-type Ba2Ca0.66Nb1.34−xFexO6−δ
Fe-doped double perovskite materials show promise for renewable-derived carbon-neutral fuel production at significantly lower temperatures than current systems.
Automated reaction progress monitoring of heterogeneous reactions: crystallization-induced stereoselectivity in amine-catalyzed aldol reactions
A prototype solution/slurry automated sampling instrument reveals the origin of diastereoselectivity in this organocatalyzed aldol reaction.
About this collection
Guest edited by Professors Philip Jessop, Queen’s University, Jennifer Love, University of British Columbia, Warren Piers, University of Calgary, Doug Stephan, University of Toronto, and Andrei Yudin, University of Toronto.
The Royal Society of Chemistry is delighted to commemorate the 100th anniversary of the Canadian Chemistry Conference and the 150th birthday of Canada with a web collection that is free to access for a limited period. The cross-journal collection highlights the excellence and breadth of Canadian research achievements across the chemical sciences and includes contributions from our Editorial and Advisory Boards.
Articles will be added to the collection as they become available.
The esteemed Guest Editors and President Rui Resendes discuss the collection in the accompanying blog post here.