Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides
Glycosylation of peptides is a promising strategy for modulating the physicochemical properties of peptide drugs and for improving their absorption through biological membranes.
Pot economy and one-pot synthesis
This review describes the importance and usefulness of pot-economy and one-pot reactions in current synthetic organic chemistry.
Peptide-based synthetic vaccines
This review summarise the current stand and future perspective on synthetic peptide-based vaccines.
Efficient metal-free photochemical borylation of aryl halides under batch and continuous-flow conditions
A metal-free C–B bond forming reaction of aryl halides under batch and continuous-flow conditions is described.
The total synthesis of K-252c (staurosporinone) via a sequential C–H functionalisation strategy
A synthesis of the bioactive indolocarbazole alkaloid K-252c (staurosporinone) via a sequential C–H functionalisation strategy is reported.
A visible-light-promoted radical reaction system for azidation and halogenation of tertiary aliphatic C–H bonds
A highly tunable visible-light-promoted reaction system for the radical-mediated functionalization of tertiary aliphatic C–H bonds of complex substrates has been developed.
Aminofluorination: transition-metal-free N–F bond insertion into diazocarbonyl compounds
Gem-aminofluorination of diazocarbonyl compounds has been achieved for the first time.
Rh(III)-catalyzed diastereoselective C–H bond addition/cyclization cascade of enone tethered aldehydes
Rh(III)-catalyzed cascade addition of C–H bonds across alkene and carbonyl π-bonds to form two new σ C–C bonds is accomplished.
Visible light-mediated gold-catalysed carbon(sp2)–carbon(sp) cross-coupling
A new method for the alkynylation of aryldiazonium salts with TMS-alkynes via dual gold and photoredox catalysis is described.
Dual gold/photoredox-catalyzed C(sp)–H arylation of terminal alkynes with diazonium salts
The arylation of alkyl and aromatic terminal alkynes by a dual gold/photoredox catalytic system is described.
Access to a new class of synthetic building blocks via trifluoromethoxylation of pyridines and pyrimidines
One-pot trifluoromethoxylation of functionalized pyridines and pyrimidines via OCF3-migraion.
Profiling the reactivity of cyclic C-nucleophiles towards electrophilic sulfur in cysteine sulfenic acid
Oxidation of a protein cysteine thiol to sulfenic acid, termed S-sulfenylation, is a reversible post-translational modification that plays a crucial role in regulating protein function and is correlated with disease states.
About this collection
We are delighted to present a collection showcasing the 50 most downloaded Chemical Science articles of 2016. This is only available for a limited time and provides an easy way to quickly access the most important papers published in Chemical Science in the past year. These articles highlight exciting and impactful research across a broad range of subject areas, analytical chemistry, chemical biology, catalysis, energy, inorganic chemistry, materials science, nanoscience, organic chemistry and physical chemistry. We hope you enjoy reading this collection!