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Themed collection Cellular and Tissue Imaging – Luminescent Tags and Probes

14 items
Review Article

Bioimaging based on fluorescent carbon dots

Herein, we review the bioimaging application of three kinds of fluorescent carbon dots (CDs), namely, graphene quantum dots (GQDs), carbon nanodots (CNDs) and polymer dots (PDs).

Graphical abstract: Bioimaging based on fluorescent carbon dots
Review Article

Zn(II)-coordination modulated ligand photophysical processes – the development of fluorescent indicators for imaging biological Zn(II) ions

Knowledge of Zn(II) coordination-modulated ligand photophysics is the foundation for developing fluorescent indicators that help address challenges in Zn(II) biology.

Graphical abstract: Zn(ii)-coordination modulated ligand photophysical processes – the development of fluorescent indicators for imaging biological Zn(ii) ions
Review Article

Carbon-based quantum dots for fluorescence imaging of cells and tissues

On recent advances in the development of carbon-based quantum dots, carbon dots in particular, for fluorescence imaging of cells and tissues.

Graphical abstract: Carbon-based quantum dots for fluorescence imaging of cells and tissues
Review Article

Utilization of the photophysical and photochemical properties of phosphorescent transition metal complexes in the development of photofunctional cellular sensors, imaging reagents, and cytotoxic agents

In this review article, we describe very recent applications of phosphorescent transition metal complexes in intracellular biosensing, bioimaging, and phototherapeutics.

Graphical abstract: Utilization of the photophysical and photochemical properties of phosphorescent transition metal complexes in the development of photofunctional cellular sensors, imaging reagents, and cytotoxic agents
Open Access Communication

Click chemistry facilitates direct labelling and super-resolution imaging of nucleic acids and proteins

We demonstrate super-resolution imaging of proteins and nucleic acids that were densely labelled with fluorophores using the concept of “click chemistry”.

Graphical abstract: Click chemistry facilitates direct labelling and super-resolution imaging of nucleic acids and proteins
Communication

One-pot synthesis, characterisation and kinetic stability of novel side-bridged pentaazamacrocyclic copper(II) complexes

Facile, one-step syntheses for novel side-bridged pentaazamacrocyclic copper(II) complexes are described. Detailed structural and spectroscopic characterisation was performed, and stability investigated, to assess their potential as bifunctional chelators for copper radiopharmaceuticals.

Graphical abstract: One-pot synthesis, characterisation and kinetic stability of novel side-bridged pentaazamacrocyclic copper(ii) complexes
Open Access Paper

Two-photon phosphorescence lifetime imaging of cells and tissues using a long-lived cyclometallated Npyridyl^Cphenyl^Npyridyl Pt(II) complex

The ‘longer’ picture: emission bio-imaging over microsecond time frame with scanning, multi-photon posphorescence-lifetime-imaging-microscopy (PLIM).

Graphical abstract: Two-photon phosphorescence lifetime imaging of cells and tissues using a long-lived cyclometallated Npyridyl^Cphenyl^Npyridyl Pt(ii) complex
Paper

Bio-imaging with neutral luminescent Pt(II) complexes showing metal⋯metal interactions

Self-assembled platinum compounds resulting in stable, highly emissive and long-lived species are reported for cell imaging.

Graphical abstract: Bio-imaging with neutral luminescent Pt(ii) complexes showing metal⋯metal interactions
Paper

8-TQEN (N,N,N′,N′-tetrakis(8-quinolylmethyl)ethylenediamine) analogs as fluorescent cadmium sensors: strategies to enhance Cd2+-induced fluorescence and Cd2+/Zn2+ selectivity

Two 8-TQEN analogs, 6-MeO-8-TQEN (1b) and 8-TQOEPN (2c), exhibited fluorescent responses selective to Cd2+.

Graphical abstract: 8-TQEN (N,N,N′,N′-tetrakis(8-quinolylmethyl)ethylenediamine) analogs as fluorescent cadmium sensors: strategies to enhance Cd2+-induced fluorescence and Cd2+/Zn2+ selectivity
Paper

Wavelength and shape dependent SERS study to develop ultrasensitive nanotags for imaging of cancer cells

A systematic study of the factors contributing to SERS signal enhancement has lead to the development of ultrasensitive nanotags for cancer cell imaging.

Graphical abstract: Wavelength and shape dependent SERS study to develop ultrasensitive nanotags for imaging of cancer cells
Paper

Emissive europium complexes that stain the cell walls of healthy plant cells, pollen tubes and roots

Five europium complexes have been assessed for their ability to stain live plant cells, roots and pollen tubes using time resolved imaging and spectroscopy.

Graphical abstract: Emissive europium complexes that stain the cell walls of healthy plant cells, pollen tubes and roots
Paper

Imaging lipid order changes in endosome membranes of live cells by using a Nile Red-based membrane probe

Changes in the composition of endosome membranes during endocytosis can be imaged in live cells with the NR12S membrane probe.

Graphical abstract: Imaging lipid order changes in endosome membranes of live cells by using a Nile Red-based membrane probe
Paper

A near-infrared fluorescent sensor for selective detection of cysteine and its application in live cell imaging

We develop a NIR fluorescent sensor based on cyanine dyes for the selective detection of Cys.

Graphical abstract: A near-infrared fluorescent sensor for selective detection of cysteine and its application in live cell imaging
From the themed collection: Organic chemistry collection
Paper

Salphen metal complexes as tunable G-quadruplex binders and optical probes

The quadruplex DNA affinities of a series of metal–salphen complexes have been studied as well as the cellular uptake and localisation by confocal microscopy in the case of the platinum(II) analogues.

Graphical abstract: Salphen metal complexes as tunable G-quadruplex binders and optical probes
14 items

About this collection

Welcome to this themed collection ‘Cellular and Tissue Imaging – Luminescent Tags and Probes’. Cellular and tissue imaging provides critical tools for scientists to understand cellular functions, combat disease and develop better medicines. There is a broad range of molecules/compounds that are effective in cellular imaging, including fluorescent organic dyes, phosphorescent metal complexes, luminescent lanthanide compounds and nanoparticles. Guest Edited by Professor Suning Wang (Queen’s University, Canada) and Professor J. Gareth Williams (University of Durham, UK), this collection presents exciting research emerging from this field.

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