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Issue 39, 2014
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Zn(ii)-coordination modulated ligand photophysical processes – the development of fluorescent indicators for imaging biological Zn(ii) ions

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Abstract

Molecular photophysics and metal coordination chemistry are the two fundamental pillars that support the development of fluorescent cation indicators. In this article, we describe how Zn(II)-coordination alters various ligand-centered photophysical processes that are pertinent to developing Zn(II) indicators. The main aim is to show how small organic Zn(II) indicators work under the constraints of specific requirements, including Zn(II) detection range, photophysical requirements such as excitation energy and emission color, temporal and spatial resolutions in a heterogeneous intracellular environment, and fluorescence response selectivity between similar cations such as Zn(II) and Cd(II). In the last section, the biological questions that fluorescent Zn(II) indicators help to answer are described, which have been motivating and challenging this field of research.

Graphical abstract: Zn(ii)-coordination modulated ligand photophysical processes – the development of fluorescent indicators for imaging biological Zn(ii) ions

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Publication details

The article was received on 14 Jan 2014, accepted on 10 Apr 2014 and first published on 16 Apr 2014


Article type: Review Article
DOI: 10.1039/C4RA00354C
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RSC Adv., 2014,4, 20398-20440

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    Zn(II)-coordination modulated ligand photophysical processes – the development of fluorescent indicators for imaging biological Zn(II) ions

    L. Zhu, Z. Yuan, J. T. Simmons and K. Sreenath, RSC Adv., 2014, 4, 20398
    DOI: 10.1039/C4RA00354C

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